Exploring biomarkers of lung diseases air pollution
There is a clear correlation between air pollution from incomplete combustion of fossil and biomass fuels and prevalent cardiovascular and respiratory diseases, such as chronic obstructive pulmonary disease (COPD). Further investigation of the underlying physiological mechanisms is hampered by the invasive, painful and time consuming nature of existing clinical methods. The aim of the project is to obtain new, fundamental knowledge about the health effects of air pollution by detection of trace gases in exhaled human breath. Breath gas analysis is a rapidly growing area of research for fast and non-invasive detection of biomarkers relevant to medical diagnostics, biomonitoring and toxicology.
R. Ghorbani, F. M. Schmidt, ICL-based TDLAS sensor for real-time breath gas analysis of carbon monoxide isotopes, Optics Express 25, 12743-12752 (2017).
R. Ghorbani, F. M. Schmidt, Real-time breath gas analysis of CO and CO2 using an EC-QCL, Applied Physics B 123, 144 (2017).
F. M. Schmidt, O. Vaittinen, M. Metsälä, M. Lehto, C. Forsblom, P.-H. Groop, L. Halonen, Ammonia in breath and emitted from skin, Journal of Breath Research 7, 017109 (2013).