The genetic information encoded in our second genome, the mitochondrial DNA (mtDNA), is required for efficient energy production. Defects in mtDNA or changes in its copy number can alter cellular energy metabolism, and are associated with several genetic diseases as well as some forms of cancer.
Our group is interested in the causes and consequences of mtDNA instability, especially how mtDNA instability is signaled to the rest of the cell. We use a combination of in vitro biochemistry, mammalian cell culture and yeast genetics to explore the basic mechanisms that ensure the maintenance of this small but (in most organisms) essential genome.
To find out more about our research group, please visit our website.