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Staff photo Paulina Wanrooij

Paulina Wanrooij

Mitochondrial DNA and the DNA damage response

See my newest research at: https://www.biorxiv.org/content/10.1101/746719v1

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Affiliation
Research fellow (assistant professor) at Department of Medical Biochemistry and Biophysics
Location
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Our genetic information is constantly under attack from various insults such as radiation and reactive oxygen species. To protect our DNA against these attacks, our cells have evolved the DNA damage response, an intricate regulatory network that is our front line of defense against cancer. The DNA damage response regulates key cellular processes such as DNA repair, cell division and dNTP synthesis, and has also been found to have implications for mitochondrial DNA, our second genome. Our group investigates the relationship between mitochondrial DNA and the DNA damage response with the aim to better understand the mechanisms that underlie conditions such as cancer and various mitochondrial diseases.

2019
Journal of Biological Chemistry
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
2019
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
2018
Journal of Virology, American Society for Microbiology 2018, Vol. 92, (19)
Nystrom, Kristina; Wanrooij, Paulina H.; Waldenstrom, Jesper; et al.
2018
PLoS Genetics, Public library science 2018, Vol. 14, (3)
Forslund, Josefin M. E.; Pfeiffer, Annika; Stojkovič, Gorazd; et al.
2017
International Journal of Molecular Sciences, MDPI AG 2017, Vol. 18, (7)
Boldinova, Elizaveta O.; Wanrooij, Paulina H.; Shilkin, Evgeniy S.; et al.
2017
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
2017
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
2016
Scientific Reports, Vol. 6
Stojkovic, Gorazd; Makarova, Alena V.; Wanrooij, Paulina H.; et al.
2016
Journal of Biological Chemistry, Vol. 291, (1) : 393-401
Wanrooij, Paulina H.; Tannous, Elias; Kumar, Sandeep; et al.
2016
Journal of Biological Chemistry, Vol. 291, (26) : 13436-13447
Sawicka, Marta; Wanrooij, Paulina H.; Darbari, Vidya C.; et al.

Research groups

Head of project
Paulina Wanrooij