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Staff photo Paulina Wanrooij

Paulina Wanrooij

Mitochondrial DNA and the DNA damage response

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Works at

KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Our genetic information is constantly under attack from various insults such as radiation and reactive oxygen species. To protect our DNA against these attacks, our cells have evolved the DNA damage response, an intricate regulatory network that is our front line of defense against cancer. The DNA damage response regulates key cellular processes such as DNA repair, cell division and dNTP synthesis, and has also been found to have implications for mitochondrial DNA, our second genome. Our group investigates the relationship between mitochondrial DNA and the DNA damage response with the aim to better understand the mechanisms that underlie conditions such as cancer and various mitochondrial diseases.

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
PLoS Genetics, Public library science 2018, Vol. 14, (3)
Forslund, Josefin M. E.; Pfeiffer, Annika; Stojkovič, Gorazd; et al.
Journal of Virology, American Society for Microbiology 2018, Vol. 92, (19)
Nystrom, Kristina; Wanrooij, Paulina H.; Waldenstrom, Jesper; et al.
International Journal of Molecular Sciences, MDPI AG 2017, Vol. 18, (7)
Boldinova, Elizaveta O.; Wanrooij, Paulina H.; Shilkin, Evgeniy S.; et al.
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Journal of Biological Chemistry, Vol. 291, (26) : 13436-13447
Sawicka, Marta; Wanrooij, Paulina H.; Darbari, Vidya C.; et al.
Scientific Reports, Vol. 6
Stojkovic, Gorazd; Makarova, Alena V.; Wanrooij, Paulina H.; et al.
Journal of Biological Chemistry, Vol. 291, (1) : 393-401
Wanrooij, Paulina H.; Tannous, Elias; Kumar, Sandeep; et al.

Research groups

Head of research
Paulina Wanrooij