Mitochondrial DNA and the DNA damage response
See my newest research at: https://www.biorxiv.org/content/10.1101/746719v1
Our genetic information is constantly under attack from various insults such as radiation and reactive oxygen species. To protect our DNA against these attacks, our cells have evolved the DNA damage response, an intricate regulatory network that is our front line of defense against cancer. The DNA damage response regulates key cellular processes such as DNA repair, cell division and dNTP synthesis, and has also been found to have implications for mitochondrial DNA, our second genome. Our group investigates the relationship between mitochondrial DNA and the DNA damage response with the aim to better understand the mechanisms that underlie conditions such as cancer and various mitochondrial diseases.