Research project Which molecular and cellular mechanisms underlie the pathology of such devastating diseases as Alzheimer’s and Parkinson’s diseases and many other amyloid disorders?
Protein self-association into amyloid oligomers and fibrils and their deposition in the body is a hallmark of a number of human pathologies including Alzheimer's and Parkinson's diseases, Skellefteå disease, diabetes mellitus and others. We study in depth the multiple faces of this phenomenon, including structural and regulatory mechanisms governing amyloid formation in vivo and in vitro, cytotoxicity of amyloids and misfolded protein complexes towards normal and tumor cells, immune response to them in the biological fluids of Alzheimer's and Parkinson's disease patients as well as the applications of amyloids as novel nanomaterials in nanobiotechnology.
VR-M, 2003-2008: SEK 2,775,000
VR (rådsforskare), 2003-2007: SEK 4,131,000
Kempe (instrument), 2003: SEK 2,200,000
Med.fak, 2004-2006: SEK 165,000
Vladimir Zamotin, doktorand
Mantas Malisauskas, doktorand
Kristina Wilhelm, doktorand
Kiran Yanamandra, doktorand