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Staff photo Ludmilla Morozova-Roche

Ludmilla Morozova-Roche

Amyloid formation - from molecular mechanisms to disease and novel nanomaterials

Works at

Affiliation
Location
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Protein self-association into amyloid oligomers and fibrils and their deposition in the body is a hallmark of a number of human pathologies including Alzheimer's and Parkinson's diseases, diabetes mellitus and others. We study in depth the multiple faces of this phenomenon, including structural and regulatory mechanisms governing amyloid formation in vivo and in vitro , cytotoxicity of amyloids and misfolded protein complexes towards normal and tumor cells, immune response to them in the biological fluids of Alzheimer's and Parkinson's disease patients as well as the applications of amyloids as novel nanomaterials in nanobiotechnology.

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (16)
Arabuli, Lili; Iashchishyn, Igor; Romanova, Nina; et al.
ACS Applied Materials and Interfaces, American Chemical Society (ACS) 2021, Vol. 13, (23) : 26721-26734
Chaudhary, Himanshu; Iashchishyn, Igor A.; Romanova, Nina V.; et al.
The FEBS Journal, John Wiley & Sons 2021, Vol. 288, (6) : 1887-1905
Jakubec, Martin; Barias, Espen; Furse, Samuel; et al.
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (11)
Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2021, Vol. 12, (11) : 1905-1918
Leri, Manuela; Chaudhary, Himanshu; Iashchishyn, Igor; et al.
New Phytologist
Majda, Mateusz; Kozlova, Liudmila; Banasiak, Alicja; et al.
ACS Omega, American Chemical Society (ACS) 2020, Vol. 5, (6) : 2856-2864
Chen, Hao; Sun, Dan; Tian, Yin; et al.
Chemical Science, Royal Society of Chemistry 2020, Vol. 11, (27) : 7031-7039
Pansieri, Jonathan; Iashchishyn, Igor A.; Fakhouri, Hussein; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2020, Vol. 11, (21) : 3549-3556
Tian, Yin; Cao, Rui; Che, Bingchen; et al.
PLOS ONE, PUBLIC LIBRARY SCIENCE 2019, Vol. 14, (2)
Huang, Qin; Sun, Dan; Hussain, Muhammad Zubair; et al.
ACS Chemical Biology, AMER CHEMICAL SOC 2019, Vol. 14, (7) : 1410-1417
Pansieri, Jonathan; Ostojic, Lucija; Iashchishyn, Igor; et al.
Neuroscience Letters, ELSEVIER IRELAND LTD 2019, Vol. 699 : 199-205
Wang, Chao; Iashchishyn, Igor; Kara, John; et al.
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 338A-338A
Williamson, Philip T. F.; Horrocks, Jack; Maheswaran, Luckshi; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (3) : 568-577
Gruden, Marina A.; Davydova, Tatiana V.; Kudrin, Vladimir S.; et al.
Journal of Neuroinflammation, BioMed Central 2018, Vol. 15
Horvath, Istvan; Iashchishyn, Igor; Moskalenko, Roman A.; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (6) : 1338-1348
Iashchishyn, Igor A.; Gruden, Marina A.; Moskalenko, Roman A.; et al.
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Wang, Chao; Iashchishyn, Igor; Pansieri, Jonathan; et al.
Chemical Science, ROYAL SOC CHEMISTRY 2017, Vol. 8, (12) : 8247-8254
Baldassarre, Maurizio; Baronio, Cesare M.; Morozova-Roche, Ludmilla A.; et al.
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Cell reports, Vol. 18, (9) : 2077-2087
Goldberg, Emily L.; Asher, Jennifer L.; Molony, Ryan D.; et al.
Bulletin of experimental biology and medicine, SPRINGER 2017, Vol. 162, (4) : 430-432
Gruden, M. A.; Davydova, T. V.; Fomina, V. G.; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (6) : 1170-1176
Horvath, Istvan; Iashchishyn, Igor A.; Forsgren, Lars; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (10) : 2152-2158
Iashchishyn, Igor A.; Sulskis, Darius; Ngoc, Mai Nguyen; et al.
Pathologia, Zaporizʹkyĭ derz͡havnyĭ medychnyĭ universytet 2017, (1) : 49-56
Moskalenko, R. A.; Romaniuk, A. M.; Iashchishyn, Igor; et al.
Scientific Reports, Vol. 6
Baumann, Anne; Jorge-Finnigan, Ana; Jung-KC, Kunwar; et al.
Behavioural Brain Research, Vol. 306 : 106-116
Gruden, Marina A.; Davydova, Tatiana V.; Wang, Chao; et al.
ACS Chemical Neuroscience, Vol. 7, (1) : 34-39
Horvath, Istvan; Jia, Xueen; Johansson, Per; et al.
Experimental Eye Research, Vol. 152 : 1-9
Minkevich, Natalya I.; Morozova-Roche, Ludmilla A.; Iomdina, Elena N.; et al.
International Journal of Molecular Medicine, Spandidos 2016, Vol. 38 : S28-S28
Morozova-Roche, Ludmilla
Behavioural Brain Research, Vol. 279 : 191-201
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
PLOS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
Journal of Physical Chemistry Letters, Vol. 5, (18) : 3254-3258
Fodera, Vito; Vetri, Valeria; Wind, Thea S.; et al.
Behavioural Brain Research, Elsevier 2014, Vol. 263 : 158-168
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
Journal of Neuroimmunology, Vol. 268, (1-2) : 99-99
Gruden, Marina A.; Sewell, Robert D. E.; Yanamandra, Kiran; et al.
ChemBioChem (Print), Wiley-VCH Verlagsgesellschaft 2014, Vol. 15, (18) : 2693-2702
Kaspersen, Jørn D.; Pedersen, Jannik N.; Hansted, Jon G.; et al.
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
PLOS ONE, Public Library of Science 2013, Vol. 8, (11) : Article Number: UNSP e80649-
Clementi, Emily A.; Wilhelm, Kristina R.; Schleucher, Juergen; et al.
PLOS ONE, Public Library of Science 2013, Vol. 8, (3) : e58218-
Eremenko, Ekaterina; Ben-Zvi, Anat; Morozova-Roche, Ludmilla A.; et al.
Behavioural Brain Research, Vol. 243 : 205-212
Gruden, Marina A.; Davidova, Tatiana V.; Yanamandra, Kiran; et al.
PLOS ONE, Public Library Science 2013, Vol. 8, (7) : e68912-
Vetri, Valeria; Leone, Maurizio; Morozova-Roche, Ludmilla A.; et al.
Journal of Physical Chemistry B, American Chemical Society (ACS) 2013, Vol. 117, (28) : 8392-9
Xu, Weixin; Zhang, Ce; Morozova-Roche, Ludmilla; et al.
RSC Advances, RSC Publishing 2013, Vol. 3, (46) : 24081-24089
Zhao, Li Na; Zhang, Tong; Zhang, Ce; et al.
Journal of Biological Chemistry, Vol. 287, (50) : 42233-42242
Botelho, Hugo M.; Leal, Sonia S.; Cardoso, Isabel; et al.
Chemical Science, Vol. 3, (12) : 3468-3473
Bryan, Thomas; Luo, Xiliang; Forsgren, Lars; et al.
Amyloid Proteins: Methods and Protocols, Springer Science+Business Media B.V. 2012 : 387-401
Gharibyan, Anna; Raveh, Dina; Morozova-Roche, Ludmilla
Neuroimmunomodulation, Vol. 19, (6) : 334-342
Gruden, Marina A.; Yanamandra, Kiran; Kucheryanu, Valery G.; et al.
11th international conference on fundamental and applied aspects of physical chemistry. Society of physical chemistry of Serbia. 24-28 September 2012, Belgrade.
Morozova-Roche, Ludmilla
New York: Nova Science Publishers, Inc. 2012
Morozova-Roche, Ludmilla; Berliner, Lawrence J.; Permyakov, Eugene A.

Research groups

Head of research
Ludmilla Morozova-Roche

Research projects