Gene-lifestyle interactions in dental endpoints (GLIDE)
GLIDE is a cohort-based project that aims at understanding the individual susceptibility/resistance to dental caries and periodontal disease and to use genes to evaluate causality between dental diseases and medical conditions and vice versa.
Caries and periodontal disease are lifestyle related diseases with large individual variations and with associations to other lifestyle related disease. Studies of genes and their interactions with lifestyle factors may increase the understanding of the variation in susceptibility to dental diseases. In GLIDE dental data for participants in the population-based health screenings in Västerbotten or within the international GLIDE consortium with cohorts in Sweden, Finland, Germany, Great Britain (including UK Biobank), USA, and Japan are used in observational- and genetic epidemiology studies. Causality is evaluated in Mendelian randomization analyses. The GLIDE cohort includes more than half a million individuals with one or more visits.