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HyPo: Preoperative fluid management and heart failure in non-cardiac surgery

Research project Hemodynamic instability may jeopardize patient safety and increase perioperative complication rate. The study objective is screening of prevalence of preoperative hypovolemia and heart failure. In addition, effects of preoperative fluid optimization in cardiac function and hemodynamic stability undergoing general surgery are studied.

Perioperative hemodynamic instability and non-optimized venous return may jeopardize patient safety and increase cardiovascular and respiratory complication rate. The objective of the study is screening of prevalence of preoperative hypovolemia and heart failure. In addition, effects of preoperative fluid optimization in biventricular cardiac function and hemodynamic stability undergoing general surgery are studied. In this randomized controlled trial, approximately 250 individuals, between 18-80 years, who have been accepted for elective surgery (breast cancer, thyroidal or gastrointestinal surgery) will be included.

Head of project

Tomi Myrberg
Associate professor, senior consultant (attending) physician
E-mail
Email

Project overview

Project period:

2017-01-31 2023-05-31

Participating departments and units at Umeå University

Department of Surgical and Perioperative Sciences

Research subject

Clinical medicine

Project description

Perioperative hemodynamic instability and non-optimized venous return may jeopardize patient safety and increase cardiovascular and respiratory complication rate. To minimize anesthesia related perioperative complications identification of risk patients and implementation of individualized fluid therapy protocols are crucial. Preoperative knowledge of hemodynamic and hydration baseline is the cornerstone in able to apply adequate intraoperative fluid therapy and anesthesia management. Preferably, preoperative cardiac assessment; i.e. venous return, filling pressures and the function of the heart; should be conducted objectively for example by use of transthoracic echocardiography.

The objective of the study is screening of prevalence of preoperative hypovolemia and heart failure. In addition, effects of preoperative fluid optimization in biventricular cardiac function and hemodynamic stability undergoing general surgery are studied. In this randomized controlled trial, approximately 250 individuals, between 18-80 years, who have been accepted for elective surgery (breast cancer, thyroidal or gastrointestinal surgery) will be included.

Key words: echocardiography, venous return, anesthesia, heart failure, fluid therapy, HyPo.