Knee Function after ACL Injury - genetic predisposition, clinical and laboratory assessment and long term consequences.

Research project Rupture of the anterior cruciate (ACL) ligament in the knee is common, most often in young people performing sport. The injury results in instability, weakness and pain/osteoarthritis. Treatment is physiotherapy with or without surgery, but it is still not known what is best in the short or long term.

The project is a follow up of more than hundred persons who suffered an ACL 17-23 years ago, of whom half had surgery. The persons are examined clinically, with x-rays, by interviews and they perform physical functional tests in a movement laboratory. The results are analyzed with regard to treatment and development of osteoarthritis. We also develop new measures of knee function and investigate genetical predisposition for ACL injury and osteoarthritis.

Head of project

Charlotte Häger Professor, combined with clinical employment

+46 90 786 92 75

Project overview

Project period

Start date: 2015-01-01

Funding

The Swedish Research Council, 2011-2017: SEK 6,400,000
VLL spjutspetsmedel, 2014-2016: SEK 2,700,000
Centrum för idrottsforskning, 2013-2014: SEK 154,000
Reumatikerförbundet, 2014: SEK 200,000
VLL ALF medel, 2016-2017: SEK 600,000

Research subject

Clinical medicine, Public health and health care science

Project members

Jonas Selling Research engineer

Email

+46 90 786 94 29

Helena Grip Other position, adjunct associate professor

Email

+46 90 785 40 29

Lina Schelin Associate professor, other position

Email

+46 90 786 55 30

Johan Strandberg Doctoral student

Email

+46 90 786 88 26

Jonas Markström Postdoctoral position, postdoctoral fellow

Email

+46 90 786 66 65

Andrew Strong Doctoral student

Email

+46 90 786 56 28

Eva Tengman Other position, associate professor

Email

+46 90 786 93 96

Ashokan Arumugam Other position

Email
Participating departments and units
Department of Community Medicine and Rehabilitation
Faculty of Medicine

Project description

Injury of the anterior cruciate ligament (ACL) in the knee is common, and treated with physiotherapy with or without surgery. There is still no evidence which is the best option, with respect to long term function and the risk of developing osteoarthritis (OA). This is partly due to a lack of gold standard on how to assess knee function and our lack of understanding of possible hereditary risk factors. Our aims are 1) to comprehensively evaluate knee function after ACL injury regarding the long term consequences and impact on daily life, and how the treatment given initially relates to the outcome; 2) to provide new and improved clinical knee assessment, as well as protocols for laboratory based movement assessment targeting the functional control of the knee, which do not currently exist; 3) explore genetic predisposition with respect to ligament tissue structure, development of OA, and physical risk taking, all extremely novel. We study a unique cohort with two groups who had ACL injury on average 23 (17-31) years ago: one group had physiotherapy and surgery and the other physiotherapy alone, and compare to healthy controls. Significance: There is no equivalent study with extensive data collection including movement analysis so long after injury. We strive to meet the highlighted need for improved physiotherapy tools to guide and evaluate treatment, tailored to the individual. The genetic approach may shed a completely new light on injury prevention.