Research project Protein diseases such as Alzheimer’s Disease (AD) and ALS are some of the most serious diseases leading to death in the Western world. Unsettled proteins play a major part in the course of the pathologic event for this disease family.
In AD, which also is the most common form of senile dementia, the pathologic development is due to the formation of millions of amyloid particles (plack) in the patients’ brain. Most of the plack consists of amyloid-b proteins (Ab). We will use a cross-disciplinary approach on Ab as a model system to characterize the fundamental differences between protein aggregation occurring on membrane surfaces and in solution.