Research project We study the regulation of nucleotide levels in mammalian cells and in pathogens such as Trypanosoma brucei. This parasite causes African sleeping sickness.
Nucleotides have central roles in cellular metabolism by being energy donors and as building blocks in DNA and RNA. It is very important that the cellular amount of nucleotides is regulated and there are many genetic diseases described caused by disbalanced nucleotide levels. We are studying the regulation of some of the enzymes involved in the nucleotide metabolism with a main focus on ribonucleotide reductase and nucleoside kinases. Trypanosoma brucei causes African sleeping sickness, a fatal disease to which there is no good treatment. Current medicines are limited by efficacy and severe toxicity. We try to exploit differences in nucleotide metabolism between the trypanosomes and mammalian cells in order to selectively kill the parasites with minimized side effects.
SIDA, 2010-2012: SEK 1,800,000
The Swedish Research Council, 2010-2015: SEK 3,600,000
Carl Tryggers stiftelse, 2013: SEK 222,000
Carl Tryggers stiftelse, 2016: SEK 377,000