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Research project The understanding of protein folding and misfolding processes, and how external factors affect these reactions, are critical for finding rational treatment of many debilitating conditions like Alzheimer’s and Parkinson's disease, type II diabetes and prion diseases. Knowledge about protein folding is also crucial in protein design and protein-structure prediction efforts.
Although overlooked in most in vitro folding studies, proteins fold and function in crowded cell environments that are full of macromolecules. This reduction of free volume is predicted to dramatically affect protein biophysical properties. To address this, we will investigate a selection of model proteins at conditions mimicking the inside of a cell. To create cell-like conditions in our test tubes, we use inert synthetic macromolecular crowding agents of varying shape and size and amount. Our goals are to obtain mechanisms for how the environment in living organisms regulate protein stability, folding mechanisms, the final folded structure, and physiological function.
Finansår , 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020
huvudman: Pernilla Wittung-Stafshede, finansiar: Umeå universitet: karriärbidrag, y2003: , y2004: , y2005: , y2006: , y2007: , y2008: , y2009: , y2010: , y2011: , y2012: , y2013: , y2014: , y2015: , y2016: , y2017: , y2018: , y2019: , y2020: ,
huvudman: Pernilla Wittung-Stafshede , finansiar: Göran Gustafsson stiftelse, y2003: , y2004: , y2005: , y2006: , y2007: , y2008: , y2009: , y2010: , y2011: , y2012: , y2013: , y2014: , y2015: , y2016: , y2017: , y2018: , y2019: , y2020: ,
huvudman: Pernilla Wittung-Stafshede , finansiar: Wallenberg Scholar, y2003: , y2004: , y2005: , y2006: , y2007: , y2008: , y2009: , y2010: , y2011: , y2012: , y2013: , y2014: , y2015: , y2016: , y2017: , y2018: , y2019: , y2020: ,