I am a postdoctoral fellow interested in multi-omics model and data integration. My kind of research helps to understand disease progression in both hereditary or acquired cases.
I am a postdoc in Anders Olofsson lab. I am currently working with Transthyretin Amyloidosis (ATTR) hereditary V30M gene carriers as well as wild types, to identify preliminary metabolic markers, that will help to prevent or slow down the TTR amyloid formation, thus will effectively reduce the adverse symptoms among individuals with ATTR risk. In the future I will work with other hereditary and acquired diseases focusing on metabolomics and epigenetic regulations.
I aim to create integrative data analytics models developed with multi-omics systems, which may potentially predict the metabolic signatures associated with diseases. The expected outcome could range from the development of metabolomics markers based, early signaling systems for disease incidences, as well as to be used for customized treatment plan development based on the metabolic signature of individuals (tailor made medicine).
My academic background
I did my Bachelor of Science in agriculture from Banaras Hindu University. I was fascinated by the adaptability of eucaryotes under different stressful environment, i.e., insecticide resistance development in insects as well as plant’s ability to compensate for nutrient stress. This ability among eucaryotes achieved through the mechanism called “metabolic homeostasis”. To pursue this study further, I did my Master of Science in agricultural biotechnology (molecular biology) focusing on the molecular mechanism (genomics and metabolomics) behind acaricide resistance development in a native Indian spider mite species. I found due to the predominant use of same acaricide the spider mite got mutated with isoenzymes capable of neutralizing the acaricide. I stayed in the field of metabolomics homeostasis for my doctoral studies as well, I studied non typical roles of isoenzymes and their associated pathways in metabolic homeostasis under external stress conditions in cyanobacteria. Through these studies I acquired skills to work with multi-omics systems and developed systems with integrative data analytics model.