Bethany van Guelpen

Research qualifications: Docent

Contact

Works as

Professor, consultant (attending) physician at Department of Diagnostics and Intervention Section: Oncology

27C, Målpunkt QC11, NUS, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

BMC Cancer, BioMed Central (BMC) 2026, Vol. 26, (1)

Harrison, Tabitha A.; Zaidi, Syed H.; Yin, Hang; et al.

Association of genetic liability to allergic diseases with overall and early-onset colorectal cancer risk: a mendelian randomization study

Cancer Epidemiology, Biomarkers and Prevention, American Association For Cancer Research (AACR) 2025, Vol. 34, (5) : 722-736

Alduhayh, Saleh; Laskar, Ruhina Shirin; Jiang, Xia; et al.

Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence

BMC Medicine, Vol. 23, (1)

Bouras, Emmanouil; Papagiannopoulos, Christos K.; Mustafa, Rima; et al.

mRNA extracted from frozen buffy coat samples stored long term in tubes with no RNA preservative shows promise for downstream sequencing analyses

PLOS ONE, Public Library of Science (PLoS) 2025, Vol. 20, (3)

Bovinder Ylitalo, Erik; Vidman, Linda; Harlid, Sophia; et al.

Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study

JNCI Cancer Spectrum, Vol. 9, (6)

Chalitsios, Christos V.; Markozannes, Georgios; Aglago, Elom K.; et al.

Waist circumference, a body shape index, and molecular subtypes of colorectal cancer: a pooled analysis of four cohort studies

Cancer Epidemiology, Biomarkers and Prevention, American Association For Cancer Research (AACR) 2025, Vol. 34, (4) : 568-577

Chalitsios, Christos V.; Markozannes, Georgios; Papagiannopoulos, Christos; et al.

Differential distribution of immune checkpoints across molecular subtypes of colorectal cancer

Oncoimmunology, Taylor & Francis Group 2025, Vol. 14, (1)

Edin, Sofia; Gylling, Björn; Li, Xingru; et al.

Sick leave due to stress and subsequent cancer risk: a Swedish national registry study of 516,678 cancer cases

Cancer Medicine, John Wiley & Sons 2025, Vol. 14, (8)

Hadrévi, Jenny; Lu, Sai San Moon; Slunga-Järvholm, Lisbeth; et al.

Multiple polygenic score approach in colorectal cancer risk prediction

Scientific Reports, Springer Nature 2025, Vol. 15, (1)

Jiang, Shangqing Joyce; Thomas, Minta; Rosenthal, Elisabeth A.; et al.

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare

Nature Medicine, Springer Nature 2025, Vol. 31 : 1730-1732

Kämpe, Anders; Gudmundsson, Sanna; Walsh, Colum P.; et al.

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator

International Journal of Epidemiology, Oxford University Press 2025, Vol. 54, (1)

Lee, Matthew A.; Hatcher, Charlie A.; Hazelwood, Emma; et al.

Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients

International Journal of Cancer, John Wiley & Sons 2025, Vol. 156, (9) : 1703-1715

Lu, Sai San Moon; Rutegård, Martin; Häggström, Christel; et al.

Functional variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with increased risk of colorectal cancer

Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (7) : 617-625

Prizment, Anna; Standafer, Abby; Qu, Conghui; et al.

Cohort profile: the Northern Sweden health and disease study (NSHDS)

International Journal of Epidemiology, Oxford University Press 2025, Vol. 54, (1)

Späth, Florentin; Wennberg, Patrik; Johansson, Robert; et al.

Enhancing existing tumour biobanks in European prospective cohort studies

The Lancet Regional Health: Europe, Elsevier 2025, Vol. 53

Ugai, Tomotaka; van Guelpen, Bethany; Mucci, Lorelei A.; et al.

Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing

American Journal of Clinical Nutrition, Elsevier 2024, Vol. 120, (3) : 664-673

Aglago, Elom K.; Qu, Conghui; Harlid, Sophia; et al.

Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk

Scientific Reports, Springer Nature 2024, Vol. 14, (1)

Bodén, Stina; Zheng, Rui; Ribbenstedt, Anton; et al.

Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis

International Journal of Epidemiology, Oxford University Press 2024, Vol. 53, (3)

Bouras, Emmanouil; Gill, Dipender; Zuber, Verena; et al.

Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Nature Communications, Springer Nature 2024, Vol. 15, (1)

Chen, Zhishan; Guo, Xingyi; Tao, Ran; et al.

Cohort profile: the Obesity and Disease Development Sweden (ODDS) study, a pooled cohort

BMJ Open, BMJ Publishing Group Ltd 2024, Vol. 14, (7)

da Silva, Marisa; Fritz, Josef; Mboya, Innocent B.; et al.

Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer

Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (22)

Drew, David A.; Kim, Andre E.; Lin, Yi; et al.

Opposing roles by KRAS and BRAF mutation on immune cell infiltration in colorectal cancer: possible implications for immunotherapy

British Journal of Cancer, Springer Nature 2024, Vol. 130

Edin, Sofia; Gylling, Björn; Li, Xingru; et al.

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

EBioMedicine, Elsevier 2024, Vol. 101

Harewood, Rhea; Rothwell, Joseph A.; Bešević, Jelena; et al.

Plasma ghrelin and risks of sex-specific, site-specific, and early-onset colorectal cancer: a Mendelian randomization analysis

Cancer Epidemiology, Biomarkers and Prevention, American Association For Cancer Research (AACR) 2024, Vol. 33, (12) : 1727-1732

Hazelwood, Emma; Lopez Manzano, Catalina; Vincent, Emma E.; et al.

Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

Annals of Oncology, Elsevier 2024, Vol. 35, (6) : 523-536

Laskar, R.S.; Qu, C.; Huyghe, J.R.; et al.

Body size and risk of colorectal cancer molecular defined subtypes and pathways: mendelian randomization analyses

EBioMedicine, Elsevier 2024, Vol. 101

Papadimitriou, Nikos; Qu, Conghui; Harrison, Tabitha A.; et al.

Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: results from the EPIC cohort

International Journal of Cancer, John Wiley & Sons 2024, Vol. 156, (5)

Reichmann, Robin; Nimptsch, Katharina; Pischon, Tobias; et al.

Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis

International Journal of Obesity, Springer Nature 2024, Vol. 48 : 709-716

Rontogianni, Marina O.; Bouras, Emmanouil; Aglago, Elom Kouassivi; et al.

Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden: the obesity and disease development Sweden (ODDS) pooled cohort study

The Lancet Regional Health: Europe, Elsevier 2024, Vol. 45

Sun, Ming; da Silva, Marisa; Bjørge, Tone; et al.

Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature

Cancer Epidemiology, Biomarkers and Prevention, American Association For Cancer Research (AACR) 2024, Vol. 33, (4) : 534-546

Thomas, Claire E.; Georgeson, Peter; Qu, Conghui; et al.

Characterization of additive gene–environment interactions for colorectal cancer risk

Epidemiology, Wolters Kluwer 2024, Vol. 36, (1) : 126-138

Thomas, Claire E.; Lin, Yi; Kim, Michelle; et al.

Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk

British Journal of Cancer, Springer Nature 2024, Vol. 130, (10) : 1687-1696

Tian, Yu; Lin, Yi; Qu, Conghui; et al.

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study

British Journal of Cancer, Springer Nature 2024, Vol. 130 : 114-124

Watts, Eleanor L.; Gonzales, Tomas I.; Strain, Tessa; et al.

Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients

BJC REPORTS, Springer Nature 2024, Vol. 2, (1)

Wesselink, Evertine; Gauderman, William; Berndt, Sonja I.; et al.

Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

British Journal of Cancer, Springer Nature 2023, Vol. 128 : 1529-1540

Aglago, Elom K.; Cross, Amanda J.; Riboli, Elio; et al.

A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Cancer Research, American Association For Cancer Research (AACR) 2023, Vol. 83, (15) : 2572-2583

Aglago, Elom K.; Kim, Andre; Lin, Yi; et al.

Plasma concentrations of gut hormones acyl ghrelin and peptide YY and subsequent risk of colorectal cancer and molecular tumor subtypes

Cancer Prevention Research, American Association for Cancer Research 2023, Vol. 16, (2) : 75-87

Bodén, Stina; Harbs, Justin; Sundkvist, Anneli; et al.

Genome-wide interaction analysis of folate for colorectal cancer risk

American Journal of Clinical Nutrition, Elsevier 2023, Vol. 118, (5) : 881-891

Bouras, Emmanouil; Kim, Andre E.; Lin, Yi; et al.

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation, and immune response

Cancer Epidemiology, Biomarkers and Prevention, American association for cancer research 2023, Vol. 32, (3) : 315-328

Carreras-Torres, Robert; Kim, Andre E.; Lin, Yi; et al.

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Nature Genetics, Nature Publishing Group 2023, Vol. 55 : 89-99

Fernandez-Rozadilla, Ceres; Timofeeva, Maria; Chen, Zhishan; et al.

An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples

Epigenetics, Taylor & Francis Group 2023, Vol. 18, (1)

Harbs, Justin; Rinaldi, Sabina; Keski-Rahkonen, Pekka; et al.

Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

American Journal of Clinical Nutrition, Elsevier 2023, Vol. 117, (1) : 33-45

Karavasiloglou, Nena; Hughes, David J.; Murphy, Neil; et al.

Prediagnostic prescription antibiotics use and survival in patients with colorectal cancer: a swedish national register-based study

Cancer Epidemiology, Biomarkers and Prevention, American Association For Cancer Research (AACR) 2023, Vol. 32, (10) : 1391-1401

Lu, Sai San Moon; Rutegård, Martin; Ahmed, Maghfoor; et al.

Body mass index and molecular subtypes of colorectal cancer

Journal of the National Cancer Institute, Oxford University Press 2023, Vol. 115, (2) : 165-173

Murphy, Neil; Newton, Christina C.; Song, Mingyang; et al.

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

BMC Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)

Nimptsch, Katharina; Aleksandrova, Krasimira; Pham, Thu Thi; et al.

Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer

International Journal of Colorectal Disease, Springer Nature 2023, Vol. 38, (1)

Renman, David; van Guelpen, Bethany; Anderson, Fredrick; et al.

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

BMC Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)

Rothwell, Joseph A.; Bešević, Jelena; Dimou, Niki; et al.

Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort

Cancer Epidemiology, Biomarkers and Prevention, American association for cancer research 2023, Vol. 32, (3) : 353-362

Su, Yu-Ru; Sakoda, Lori C.; Jeon, Jihyoun; et al.

Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study

Journal of the National Cancer Institute, Oxford University Press 2023, Vol. 115, (4) : 456-467

Sun, Ming; Fritz, Josef; Häggström, Christel; et al.

CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women

Drug Metabolism and Personalized Therapy, De Gruyter Open 2023, Vol. 38, (1) : 57-63

Söderström, Elisabet; Andersson, Jonas; Söderberg, Stefan; et al.

View publications in DiVA

Research groups

Head of research

Bethany van Guelpen Lab

Group member

Arktisk kost, hälsa och hållbarhet

Research projects

1 January 2022 until 31 December 2024

Etiology, risk prediction and early detection of colorectal cancer

1 January 2014 until 26 November 2030

The role of diet in diseases related to inflammation

Published: 23 Nov, 2023

Cancer Fund millions for research in Umeå

Published: 03 Jul, 2020

NMMP funding for collaboration projects with SciLifeLab