Håkan Hedman

Contact

Works at

Adjunct professor at Department of Radiation Sciences Units: Oncology

Målpunkt M31, Byggnad 6M, plan 3, Norrlands universitetssjukhus, Translationellt forskningscentrum (TRC) Umeå universitet, 901 87 Umeå

Hypothesis: Do LRIG proteins regulate stem cell quiescence by promoting BMP signaling?

Stem Cell Reviews and Reports, Springer 2023, Vol. 19, (1) : 59-66

Herdenberg, Carl; Hedman, Håkan

Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma

Acta Oncologica, Taylor & Francis 2022, Vol. 61, (11) : 1425-1433

Lorenzzi Löfgren de Melo, Alexandra; Linder, Anna; Sundfeldt, Karin; et al.

Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling

Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)

Abdullah Nasir, Ahmad; Herdenberg, Carl; Hedman, Håkan

LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance

Oncogene, Springer Nature 2021, Vol. 40 : 3707-3718

Billing, Ola; Holmgren, Ylva; Nosek, Daniel; et al.

Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation

Development, The Dompany of Biologists 2021, Vol. 148, (16)

De Vincenti, Ana Paula; Alsina, Fernando C.; Ferrero Restelli, Facundo; et al.

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

Communications Biology, Springer Nature 2021, Vol. 4, (1)

Herdenberg, Carl; Mutie, Pascal; Billing, Ola; et al.

LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer

BMC Cancer, BioMed Central 2020, Vol. 20, (1)

Faraz, Mahmood; Tellström, Andreas; Edwinsdotter Ardnor, Christina; et al.

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder

Kidney International, ELSEVIER SCIENCE INC 2019, Vol. 95, (5) : 1138-1152

Roberts, Neil A.; Hilton, Emma N.; Lopes, Filipa M.; et al.

LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: association with prognosis in relation to HPV‑DNA and p16^INK4a status

Oncology Reports, Spandidos Publications 2019, Vol. 42, (1) : 142-150

Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.

A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors

Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (9) : 3421-3435

Faraz, Mahmood; Herdenberg, Carl; Holmlund, Camilla; et al.

LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease

Lung Cancer, Elsevier 2018, Vol. 125 : 174-184

Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.

LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer

International journal of oncology, Vol. 52, (4) : 1189-1197

Lindquist, David; Alsina, Fernando C.; Herdenberg, Carl; et al.

Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma

Oncogenesis, Nature Publishing Group 2018, Vol. 7

Mao, Feng; Holmlund, Camilla; Faraz, Mahmood; et al.

LRIG1 Was Down-Regulated in Medullary Thyroid Cancer but No Significant Effect of LRIG1 Was Found in RET2B Transgenic Mice and Human Differentiated Thyroid Cancer

Neuroendocrinology, S. Karger 2017, Vol. 105 : 152-152

Lindquist, David; Henriksson, Roger; Hedman, Håkan

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy

Biochimica et Biophysica Acta, Elsevier 2017, Vol. 1868, (1) : 109-116

Neirinckx, Virginie; Hedman, Håkan; Niclou, Simone P.

Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma

PLOS ONE, Vol. 12, (8)

Ranhem, Cecilia; Larsson, Gabriella Lillsunde; Hedman, Håkan; et al.

Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling

EMBO Reports, Vol. 17, (4) : 601-616

Cruz Alsina, Fernando; Javier Hita, Francisco; Aldana Fontanet, Paula; et al.

Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, Vol. 310, (11) : R1045-R1052

Hellström, Martin; Ericsson, Madelene; Johansson, Bengt; et al.

LRIG1 is a prognostic biomarker in non-small cell lung cancer

Acta Oncologica, Taylor & Francis 2015, Vol. 54, (8) : 1113-1119

Kvarnbrink, Samuel; Karlsson, Terese; Edlund, Karolina; et al.

LRIG protein expression and HPV prevalence in vulvar cancer patients in northern Sweden

International Journal of Gynecological Cancer, Vol. 25, (9) : 684-684

Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

Developmental Cell, Vol. 35, (5) : 537-552

van Erp, Susan; van den Heuvel, Dianne M. A.; Fujita, Yuki; et al.

LRIG and cancer prognosis

Acta Oncologica, Informa Healthcare 2014, Vol. 53, (9) : 1135-1142

Lindquist, David; Kvarnbrink, Samuel; Henriksson, Roger; et al.

Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer

British Journal of Cancer, Nature Publishing Group 2014, Vol. 110, (7) : 1793-1800

Lindquist, David; Näsman, A.; Tarján, M.; et al.

Loss of LRIG1 Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer

Cancer Research, Vol. 74, (11) : 2928-2935

Thompson, Patricia A.; Ljuslinder, Ingrid; Tsavachidis, Spyros; et al.

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status

Neuro-Oncology, Vol. 15, (9) : 1200-1211

Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.

Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer.

Cancer Research, Vol. 73, (8: suppl 1) : 5315-

Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.

Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma

International Journal of Oncology, Spandidos Publications 2013, Vol. 42, (1) : 247-252

Muller, Susanne; Lindquist, David; Kanter, Lena; et al.

Local delivery of the soluble form of the tumor suppressor and stem cell regulator LRIG1 potently inhibits in vivo growth of glioblastomas with either wildtype or mutant EGFR expression

European Journal of Cancer, Elsevier 2013, Vol. 49, (Supplement 2) : S777-S777, Meeting Abstract: 3307

Niclou, S. P.; Johansson, M.; Tiemann, K.; et al.

Lrig2-deficient mice are protected against PDGFB-induced glioma

PLOS ONE, Vol. 8, (9) : e73635-

Rondahl, Veronica; Holmlund, Camilla; Karlsson, Terese; et al.

ELUCIDATING THE MECHANISM OF RECEPTOR TYROSINE KINASE INHIBITION BY SOLUBLE LRIG1 IN GLIOBLASTOMA

Neuro-Oncology, Oxford University Press 2013, Vol. 15, (Supplement: 3) : 28-29

Tiemann, Katja; Hedman, Håkan; Niclou, Simone P.

Synergistic killing of Glioblastoma Stem-like cells by Bortezomib and HDAC Inhibitors

Anticancer Research, International Institute of Anticancer Research 2012, Vol. 32, (7 ; Special Issue) : 2407-2413

Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.

Synergistic Killing of Glioblastoma Stem-like Cells by Bortezomib and HADC Inhibitors.

Anticancer Research, Vol. 32, (7) : 2407-2413

Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69

Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Journal of Neuro-Oncology, Vol. 108, (3) : 435-441

Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.

The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status

Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 15-16

Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.

Expression of the human LRIG genes and proteins as prognostic markers in human cancer

International Journal of Molecular Medicine, Spandidos publications 2012, Vol. 30, (Suppl 1) : S42-S42

Lindquist, David; Henriksson, Roger; Hedman, Hakan

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma

BMC Research Notes, Vol. 5, (216) : 1-5

Thomasson, Marcus; Hedman, Håkan; Ljungberg, Börje; et al.

Endogenous Inhibitors of Tyrosine Kinase Receptors: a Therapeutic Role for Soluble LRIG1 in Malignant Glioma?

European Journal of Cancer, Elsevier 2012, Vol. 48 : S152-S152

Tiemann, K.; Bernard, A.; Fack, F.; et al.

Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity.

Acta Oncologica, Informa Healthcare 2012, Vol. 51, (1) : 69-76

Wu, Xuping; Hedman, Håkan; Bergqvist, Michael; et al.

LRIG1 and the liar paradox in prostate cancer: A study of the expression and clinical significance of LRIG1 in prostate cancer.

International Journal of Cancer, Wiley 2011, Vol. 128, (12) : 2843-2852

Thomasson, Marcus; Wang, Baofeng; Hammarsten, Peter; et al.

Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1

Experimental Cell Research, New York: Academic Press 2011, Vol. 317, (4) : 504-512

Yi, Wei; Holmlund, Camilla; Nilsson, Jonas; et al.

LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix

Acta Oncologica, Informa Healthcare 2010, Vol. 49, (6) : 812-815

Hedman, Håkan; Lindström, Annika K; Tot, Tibor; et al.

Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.

Neuropathology (Kyoto. 1993), Vol. 29, (3) : 242-247

Holmlund, Camilla; Haapasalo, Hannu; Yi, Wei; et al.

Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer

Breast Cancer Research, Vol. 11, (3) : 403-

Ljuslinder, Ingrid; Golovleva, Irina; Henriksson, Roger; et al.

Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age

Clinical Neuropathology, Vol. 28, (1) : 21-27

Yi, W; Haapasalo, H; Holmlund, Camilla; et al.

Redistribution of LRIG proteins in psoriasis

Journal of Investigative Dermatology, Vol. 128, (5) : 1192-1195

Karlsson, Terese; Mark, Elisabeth B; Henriksson, Roger; et al.

LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking

International Journal of Gynecological Cancer, Vol. 18, (2) : 312-317

Lindström, Annika; Ekman, K; Stendahl, Ulf; et al.

Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.

Anticancer Research, Vol. 28, (3A) : 1493-1498

Sjödin, Anna; Ljuslinder, Ingrid; Henriksson, Roger; et al.

LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?

Eur J Cancer, Vol. 43, (4) : 676-682

Hedman, Håkan; Henriksson, Roger

LRIG1 expression in colorectal cancer

Acta Oncologica, Vol. 46, (8) : 1118-1122

Ljuslinder, Ingrid; Golovleva, Irina; Palmqvist, Richard; et al.

View publications in DiVA

Research groups

Head of research

Håkan Hedman Lab

TRC Board

Translational Research Centre