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Håkan Hedman
Contact
E-mail
hakan.hedman@umu.se
Phone
+46 90 785 28 81
Works at
Affiliation
Adjunct professor at
Department of Radiation Sciences
Units: Oncology
Location
Målpunkt M31, Byggnad 6M, plan 3, Norrlands universitetssjukhus, Translationellt forskningscentrum (TRC)
Umeå universitet, 901 87 Umeå
Publications
Publications
Research
Research
2023
Hypothesis: Do LRIG proteins regulate stem cell quiescence by promoting BMP signaling?
Stem Cell Reviews and Reports
, Springer 2023, Vol. 19, (1) : 59-66
Herdenberg, Carl; Hedman, Håkan
2022
Single-molecule array assay reveals the prognostic impact of plasma LRIG1 in ovarian carcinoma
Acta Oncologica
, Taylor & Francis 2022, Vol. 61, (11) : 1425-1433
Lorenzzi Löfgren de Melo, Alexandra; Linder, Anna; Sundfeldt, Karin; et al.
2021
Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
Scientific Reports
, Nature Publishing Group 2021, Vol. 11, (1)
Abdullah Nasir, Ahmad; Herdenberg, Carl; Hedman, Håkan
2021
LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance
Oncogene
, Springer Nature 2021, Vol. 40 : 3707-3718
Billing, Ola; Holmgren, Ylva; Nosek, Daniel; et al.
2021
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation
Development
, The Dompany of Biologists 2021, Vol. 148, (16)
De Vincenti, Ana Paula; Alsina, Fernando C.; Ferrero Restelli, Facundo; et al.
2021
LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes
Communications Biology
, Springer Nature 2021, Vol. 4, (1)
Herdenberg, Carl; Mutie, Pascal; Billing, Ola; et al.
2020
LRIG1
gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer
BMC Cancer
, BioMed Central 2020, Vol. 20, (1)
Faraz, Mahmood; Tellström, Andreas; Edwinsdotter Ardnor, Christina; et al.
2019
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder
Kidney International
, ELSEVIER SCIENCE INC 2019, Vol. 95, (5) : 1138-1152
Roberts, Neil A.; Hilton, Emma N.; Lopes, Filipa M.; et al.
2019
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: association with prognosis in relation to HPV‑DNA and p16
INK4a
status
Oncology Reports
, Spandidos Publications 2019, Vol. 42, (1) : 142-150
Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.
2018
A protein interaction network centered on leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) regulates growth factor receptors
Journal of Biological Chemistry
, The American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (9) : 3421-3435
Faraz, Mahmood; Herdenberg, Carl; Holmlund, Camilla; et al.
2018
LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease
Lung Cancer
, Elsevier 2018, Vol. 125 : 174-184
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
2018
LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer
International journal of oncology
, Vol. 52, (4) : 1189-1197
Lindquist, David; Alsina, Fernando C.; Herdenberg, Carl; et al.
2018
Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
Oncogenesis
, Nature Publishing Group 2018, Vol. 7
Mao, Feng; Holmlund, Camilla; Faraz, Mahmood; et al.
2017
LRIG1 Was Down-Regulated in Medullary Thyroid Cancer but No Significant Effect of LRIG1 Was Found in RET2B Transgenic Mice and Human Differentiated Thyroid Cancer
Neuroendocrinology
, S. Karger 2017, Vol. 105 : 152-152
Lindquist, David; Henriksson, Roger; Hedman, Håkan
2017
Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy
Biochimica et Biophysica Acta
, Elsevier 2017, Vol. 1868, (1) : 109-116
Neirinckx, Virginie; Hedman, Håkan; Niclou, Simone P.
2017
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
PLOS ONE
, Vol. 12, (8)
Ranhem, Cecilia; Larsson, Gabriella Lillsunde; Hedman, Håkan; et al.
2016
Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling
EMBO Reports
, Vol. 17, (4) : 601-616
Cruz Alsina, Fernando; Javier Hita, Francisco; Aldana Fontanet, Paula; et al.
2016
Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
, Vol. 310, (11) : R1045-R1052
Hellström, Martin; Ericsson, Madelene; Johansson, Bengt; et al.
2015
LRIG1 is a prognostic biomarker in non-small cell lung cancer
Acta Oncologica
, Taylor & Francis 2015, Vol. 54, (8) : 1113-1119
Kvarnbrink, Samuel; Karlsson, Terese; Edlund, Karolina; et al.
2015
LRIG protein expression and HPV prevalence in vulvar cancer patients in northern Sweden
International Journal of Gynecological Cancer
, Vol. 25, (9) : 684-684
Stefansson, Kristina; Oda, Husam; Öfverman, Charlotte; et al.
2015
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
Developmental Cell
, Vol. 35, (5) : 537-552
van Erp, Susan; van den Heuvel, Dianne M. A.; Fujita, Yuki; et al.
2014
LRIG and cancer prognosis
Acta Oncologica
, Informa Healthcare 2014, Vol. 53, (9) : 1135-1142
Lindquist, David; Kvarnbrink, Samuel; Henriksson, Roger; et al.
2014
Expression of LRIG1 is associated with good prognosis and human papillomavirus status in oropharyngeal cancer
British Journal of Cancer
, Nature Publishing Group 2014, Vol. 110, (7) : 1793-1800
Lindquist, David; Näsman, A.; Tarján, M.; et al.
2014
Loss of LRIG1 Locus Increases Risk of Early and Late Relapse of Stage I/II Breast Cancer
Cancer Research
, Vol. 74, (11) : 2928-2935
Thompson, Patricia A.; Ljuslinder, Ingrid; Tsavachidis, Spyros; et al.
2013
The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
Neuro-Oncology
, Vol. 15, (9) : 1200-1211
Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.
2013
Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer.
Cancer Research
, Vol. 73, (8: suppl 1) : 5315-
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
2013
Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma
International Journal of Oncology
, Spandidos Publications 2013, Vol. 42, (1) : 247-252
Muller, Susanne; Lindquist, David; Kanter, Lena; et al.
2013
Local delivery of the soluble form of the tumor suppressor and stem cell regulator LRIG1 potently inhibits in vivo growth of glioblastomas with either wildtype or mutant EGFR expression
European Journal of Cancer
, Elsevier 2013, Vol. 49, (Supplement 2) : S777-S777, Meeting Abstract: 3307
Niclou, S. P.; Johansson, M.; Tiemann, K.; et al.
2013
Lrig2-deficient mice are protected against PDGFB-induced glioma
PLOS ONE
, Vol. 8, (9) : e73635-
Rondahl, Veronica; Holmlund, Camilla; Karlsson, Terese; et al.
2013
ELUCIDATING THE MECHANISM OF RECEPTOR TYROSINE KINASE INHIBITION BY SOLUBLE LRIG1 IN GLIOBLASTOMA
Neuro-Oncology
, Oxford University Press 2013, Vol. 15, (Supplement: 3) : 28-29
Tiemann, Katja; Hedman, Håkan; Niclou, Simone P.
2012
Synergistic killing of Glioblastoma Stem-like cells by Bortezomib and HDAC Inhibitors
Anticancer Research
, International Institute of Anticancer Research 2012, Vol. 32, (7 ; Special Issue) : 2407-2413
Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
2012
Synergistic Killing of Glioblastoma Stem-like Cells by Bortezomib and HADC Inhibitors.
Anticancer Research
, Vol. 32, (7) : 2407-2413
Asklund, Thomas; Kvarnbrink, Samuel; Holmlund, Camilla; et al.
2012
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Neuro-Oncology
, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69
Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.
2012
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Journal of Neuro-Oncology
, Vol. 108, (3) : 435-441
Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.
2012
The soluble form of the tumor suppressor Lrig1 potently inhibits in vivo glioma growth irrespective of EGF receptor status
Neuro-Oncology
, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 15-16
Johansson, Mikael; Oudin, Anaïs; Tiemann, Katja; et al.
2012
Expression of the human LRIG genes and proteins as prognostic markers in human cancer
International Journal of Molecular Medicine
, Spandidos publications 2012, Vol. 30, (Suppl 1) : S42-S42
Lindquist, David; Henriksson, Roger; Hedman, Hakan
2012
Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
BMC Research Notes
, Vol. 5, (216) : 1-5
Thomasson, Marcus; Hedman, Håkan; Ljungberg, Börje; et al.
2012
Endogenous Inhibitors of Tyrosine Kinase Receptors: a Therapeutic Role for Soluble LRIG1 in Malignant Glioma?
European Journal of Cancer
, Elsevier 2012, Vol. 48 : S152-S152
Tiemann, K.; Bernard, A.; Fack, F.; et al.
2012
Expression of EGFR and LRIG proteins in oesophageal carcinoma with emphasis on patient survival and cellular chemosensitivity.
Acta Oncologica
, Informa Healthcare 2012, Vol. 51, (1) : 69-76
Wu, Xuping; Hedman, Håkan; Bergqvist, Michael; et al.
2011
LRIG1 and the liar paradox in prostate cancer: A study of the expression and clinical significance of LRIG1 in prostate cancer.
International Journal of Cancer
, Wiley 2011, Vol. 128, (12) : 2843-2852
Thomasson, Marcus; Wang, Baofeng; Hammarsten, Peter; et al.
2011
Paracrine regulation of growth factor signaling by shed leucine-rich repeats and immunoglobulin-like domains 1
Experimental Cell Research
, New York: Academic Press 2011, Vol. 317, (4) : 504-512
Yi, Wei; Holmlund, Camilla; Nilsson, Jonas; et al.
2010
LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous cell carcinoma of the uterine cervix
Acta Oncologica
, Informa Healthcare 2010, Vol. 49, (6) : 812-815
Hedman, Håkan; Lindström, Annika K; Tot, Tibor; et al.
2009
Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.
Neuropathology (Kyoto. 1993)
, Vol. 29, (3) : 242-247
Holmlund, Camilla; Haapasalo, Hannu; Yi, Wei; et al.
2009
Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer
Breast Cancer Research
, Vol. 11, (3) : 403-
Ljuslinder, Ingrid; Golovleva, Irina; Henriksson, Roger; et al.
2009
Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age
Clinical Neuropathology
, Vol. 28, (1) : 21-27
Yi, W; Haapasalo, H; Holmlund, Camilla; et al.
2008
Redistribution of LRIG proteins in psoriasis
Journal of Investigative Dermatology
, Vol. 128, (5) : 1192-1195
Karlsson, Terese; Mark, Elisabeth B; Henriksson, Roger; et al.
2008
LRIG1 and squamous epithelial uterine cervical cancer: correlation to prognosis, other tumor markers, sex steroid hormones, and smoking
International Journal of Gynecological Cancer
, Vol. 18, (2) : 312-317
Lindström, Annika; Ekman, K; Stendahl, Ulf; et al.
2008
Mammaglobin and lipophilin B expression in breast tumors and their lack of effect on breast cancer cell proliferation.
Anticancer Research
, Vol. 28, (3A) : 1493-1498
Sjödin, Anna; Ljuslinder, Ingrid; Henriksson, Roger; et al.
2007
LRIG inhibitors of growth factor signalling - double-edged swords in human cancer?
Eur J Cancer
, Vol. 43, (4) : 676-682
Hedman, Håkan; Henriksson, Roger
2007
LRIG1 expression in colorectal cancer
Acta Oncologica
, Vol. 46, (8) : 1118-1122
Ljuslinder, Ingrid; Golovleva, Irina; Palmqvist, Richard; et al.
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Research groups
Head of research
Håkan Hedman Lab
TRC Board
Translational Research Centre
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