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Intissar Anan
Contact
E-mail
intissar.anan@umu.se
Phone
+46 90 785 00 00
Works as
Affiliation
Physician
at
Department of Public Health and Clinical Medicine
Section: Gastroenterology
Location
Byggnad 1A, plan 4, målpunkt B41, Norrlands universitetssjukhus
Norrlands universitetssjukhus, 90185 Umeå
Publications
Publications
Research
Research
Mentions
Mentions
2025
Advances in the treatment of transthyretin amyloidosis
eGastroenterology
, BMJ Publishing Group Ltd 2025, Vol. 3, (3)
Anan, Intissar
2025
Misfolding of transthyretin in vivo is controlled by the redox environment and macromolecular crowding
Journal of Biological Chemistry
, American Society for Biochemistry and Molecular Biology 2025, Vol. 301, (1)
Jayaweera, Sanduni Wasana; Sahin, Melisnur; Lundkvist, Fabian; et al.
2025
The other side of variant transthyretin amyloidosis with polyneuropathy: psychosocial experience of members of Portuguese families with late onset of the disease
Journal of Community Genetics
, Springer Nature 2025, Vol. 16 : 301-309
Pereira, José D.; Santos, Andreia; Cisneros-Barroso, Eugenia; et al.
2025
Sixty years of experience with hereditary transthyretin amyloidosis: insights from the Swedish transthyretin amyloidosis registry
Journal of Internal Medicine
, John Wiley & Sons 2025, Vol. 298 : 478-488
Stenberg, Lotta; Pilebro, Björn; Anan, Intissar; et al.
2024
Assessing left atrial dysfunction in cardiac amyloidosis using LA-LV strain slope
European Heart Journal - Imaging Methods and Practice
, Oxford University Press 2024, Vol. 2, (3)
Edbom, Fredrik; Lindqvist, Per; Wiklund, Urban; et al.
2024
Anti-PEG antibodies associated with reduced therapeutic effect of patisiran in patients with hereditary transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2024, Vol. 31, (4) : 342-343
Pilebro, Björn; Wixner, Jonas; Anan, Intissar
2023
Enlarged cross-sectional area in peripheral nerves in Swedish patients with hereditary V30M transthyretin amyloidosis
Annals of Medicine
, Taylor & Francis Group 2023, Vol. 55, (2)
Arvidsson, Sandra; Eriksson, Robert; Anan, Intissar; et al.
2023
A multicentric study of the disease risks and first manifestations in Hereditary transthyretin amyloidosis (ATTRv): insights for an earlier diagnosis
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2023, Vol. 30, (3) : 313-320
Planté-Bordeneuve, Violaine; Gorram, Farida; Olsson, Malin; et al.
2022
Amyloid fibril composition type is consistent over time in patients with Val30Met (p. Val50Met) transthyretin amyloidosis
PLOS ONE
, Public Library of Science 2022, Vol. 17, (3)
Anan, Intissar; Suhr, Ole B.; Liszewska, Katarzyna; et al.
2022
Endogenous Human Proteins Interfering with Amyloid Formation
Biomolecules
, MDPI 2022, Vol. 12, (3)
Gharibyan, Anna; Jayaweera, Sanduni Wasana; Lehmann, Manuela; et al.
2022
Epidemiology of hereditary transthyretin amyloidosis in the northernmost region of Sweden: a retrospective cohort study
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2022, Vol. 29, (2) : 120-127
Mejia Baranda, Jorge; Ljungberg, Jenny; Wixner, Jonas; et al.
2022
Hereditary transthyretin amyloidosis in Sweden: Comparisons between a non-endemic and an endemic region
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2022, Vol. 29, (4) : 220-227
Samuelsson, Kristin; Jovanovic, Ana; Egervall, Karl; et al.
2022
Patisiran treatment in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy after liver transplantation
American Journal of Transplantation
, John Wiley & Sons 2022, Vol. 22, (6) : 1646-1657
Schmidt, Hartmut H.; Wixner, Jonas; Planté-Bordeneuve, Violaine; et al.
2022
Cerebellar and Cerebral Amyloid Visualized by [18F]flutemetamol PET in Long-Term Hereditary V30M (p.V50M) Transthyretin Amyloidosis Survivors
Frontiers in Neurology
, Frontiers Media S.A. 2022, Vol. 13
Unéus, Erica Irene; Wilhelmsson, Christer; Bäckström, David; et al.
2021
New data on the genetic profile and penetrance of hereditary Val30Met transthyretin amyloidosis in Sweden
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2021, Vol. 28, (2) : 84-90
Gorram, Farida; Olsson, Malin; Alarcon, Flora; et al.
2021
Structural basis for transthyretin amyloid formation in vitreous body of the eye
Nature Communications
, Nature Publishing Group 2021, Vol. 12, (1)
Iakovleva, Irina; Hall, Michael; Oelker, Melanie; et al.
2021
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
Biomolecules
, MDPI 2021, Vol. 11, (3)
Jayaweera, Sanduni Wasana; Surano, Solmaz; Pettersson, Nina; et al.
2021
Combining ECG and echocardiography to identify transthyretin cardiac amyloidosis in heart failure
Clinical Physiology and Functional Imaging
, John Wiley & Sons 2021, Vol. 41, (5) : 408-416
Löfbacka, Viktor; Suhr, Ole B.; Pilebro, Björn; et al.
2021
Metabolomics analysis for diagnosis and biomarker discovery of transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis Group 2021, Vol. 28, (4) : 234-242
Olsson, Malin; Hellman, Urban; Wixner, Jonas; et al.
2020
Abdominal fat pad biopsies exhibit good diagnostic accuracy in patients with suspected transthyretin amyloidosis
Orphanet Journal of Rare Diseases
, BioMed Central (BMC) 2020, Vol. 15, (1)
Paulsson Rokke, Hedvig; Sadat Gousheh, Nima; Westermark, Per; et al.
2019
A case report of osteoarthritis associated with hereditary transthyretin amyloidosis ATTRV30M
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2019, Vol. 26 : 29-30
Anan, Intissar; Bång, Joakim; Lundgren, Hans-Erik; et al.
2019
Transthyretin Glu54Leu - an unknown mutation within the Swedish population associated with amyloid cardiomyopathy and a unique fibril type
Scandinavian Journal of Clinical and Laboratory Investigation
, Taylor & Francis 2019, Vol. 79, (6) : 372-376
Hellman, Urban; Lång, Kenneth; Ihse, Elisabet; et al.
2019
Prevalence of transthyretin cardiac amyloidosis in a community-based heart failure population
European Heart Journal
, Oxford University Press 2019, Vol. 40 : 132-132
Lindmark, Krister; Pilebro, Björn; Solekrans, L.; et al.
2019
Self-reported gastrointestinal symptoms are more common in liver transplanted transthyretin amyloidosis patients than in healthy controls and in patients transplanted for end-stage liver disease
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis 2019, Vol. 26 : 47-48
Marberg, Therese; Karling, Pontus; Söderberg, Karin; et al.
2019
Amyloid fibril composition within hereditary Val30Met (p. Val50Met) transthyretin amyloidosis families
PLOS ONE
, Public Library Science 2019, Vol. 14, (2)
Suhr, Ole Bernt; Wixner, Jonas; Anan, Intissar; et al.
2019
Visualisation of amyloid deposition within the brain of long-term hereditary transthyretin amyloidosis survivors by 18F-flutemetamol positron emission tomography
European Journal of Neurology
, John Wiley & Sons 2019, Vol. 26, (S1) : 287-287
Unéus, Erica; Wilhelmsson, Christer; Suhr, Ole; et al.
2019
The Swedish open-label diflunisal trial (DFNS01) on hereditary transthyretin amyloidosis and the impact of amyloid fibril composition
Amyloid: Journal of Protein Folding Disorders
, Taylor & Francis Group 2019, Vol. 26 : 39-40
Wixner, Jonas; Westermark, Per; Ihse, Elisabet; et al.
2018
Atrial Fibrillation and Central Nervous Complications in Liver Transplanted Hereditary Transthyretin Amyloidosis Patients
Transplantation
, LIPPINCOTT WILLIAMS & WILKINS 2018, Vol. 102, (2) : e59-e66
Wange, Niklas; Anan, Intissar; Ericzon, Bo-Göran; et al.
2018
Management of gastrointestinal complications in hereditary transthyretin amyloidosis: a single-center experience over 40 years
Expert Review of Gastroenterology & Hepatology
, Taylor & Francis 2018, Vol. 12, (1) : 73-81
Wixner, Jonas; Suhr, Ole B.; Anan, Intissar
2018
Abnormal small bowel motility in patients with hereditary transthyretin amyloidosis
Neurogastroenterology and Motility
, Wiley-Blackwell 2018, Vol. 30, (9)
Wixner, Jonas; Törnblom, H.; Karling, Pontus; et al.
2017
The Swedish landscape of hereditary ATTR amyloidosis
Amyloid: Journal of Protein Folding Disorders
, Vol. 24, (1) : 93-94
Suhr, Ole B; Wixner, Jonas; Pilebro, Björn; et al.
2017
Effect of doxycycline and ursodeoxycholic acid on transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders
, Vol. 24, (1) : 78-79
Wixner, Jonas; Pilebro, Bjorn; Lundgren, Hans-Erik; et al.
2015
Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma
Journal of Medicinal Chemistry
, Vol. 58, (16) : 6507-6515
Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.
2015
Outcome of gastric emptying and gastrointestinal symptoms after liver transplantation for hereditary transthyretin amyloidosis
BMC Gastroenterology
, Vol. 15
Wixner, Jonas; Sundström, Torbjorn; Karling, Pontus; et al.
2014
THAOS: Gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease
Orphanet Journal of Rare Diseases
, BioMed Central (BMC) 2014, Vol. 9, (1) : 61-
Wixner, Jonas; Mundayat, Rajiv; Karayal, Onur N; et al.
2013
Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
Clinica Chimica Acta
, Vol. 419C : 127-131
Obayashi, Konen; Tasaki, Masayoshi; Jono, Hirofumi; et al.
2013
Loss of gastric interstitial cells of Cajal in patients with hereditary transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders
, Informa Healthcare 2013, Vol. 20, (2) : 99-106
Wixner, Jonas; Obayashi, Konen; Ando, Yukio; et al.
2012
Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy
Neurogastroenterology and Motility
, Wiley-Blackwell 2012, Vol. 24, (12) : 1111-e568
Wixner, Jonas; Karling, Pontus; Rydh, Anders; et al.
2010
Serum transthyretin levels in Swedish TTR V30M carriers
Amyloid: Journal of Protein Folding Disorders
, Vol. 17, (2) : 83-85
Buxbaum, Joel; Anan, Intissar; Suhr, Ole B
2008
Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients.
Clinica Chimica Acta
, Vol. 398, (1-2) : 10-4
Obayashi, Konen; Olsson, Malin; Anan, Intissar; et al.
2008
Do troponin and B-natriuretic peptide detect cardiomyopathy in transthyretin amyloidosis?
Journal of Internal Medicine
, John Wiley & Sons 2008, Vol. 263, (3) : 294-301
Suhr, Ole B; Anan, Intissar; Backman, Clas; et al.
2005
Cardiomyopathy in Swedish patients with the Gly53Glu and His88Arg transthyretin variants.
Amyloid
, Vol. 12, (3) : 184-8
Holmgren, Gösta; Hellman, Urban; Anan, Intissar; et al.
2005
Advanced glycation end product is implicated in amyloid-related kidney complications
Scandinavian Journal of Clinical and Laboratory Investigation
, Informa Healthcare 2005, Vol. 65, (4) : 263-272
Matsunaga, N; Anan, Intissar; Rosenberg, P; et al.
2003
Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portuguese type (Val30Met).
Amyloid: Journal of Protein Folding Disorders
, Vol. 10, (2) : 121-6
Suhr, Ole B; Anan, Intissar; Åhlström Riklund, Katrine; et al.
2002
Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation.
Acta Neuropathologica
, Vol. 104, (5) : 441-7
Matsunaga, Noriko; Anan, Intissar; Forsgren, Sture; et al.
2002
Reduction of free radical activity in amyloid deposits following liver transplantation for familial amyloidotic polyneuropathy.
Journal of Internal Medicine
, Vol. 251, (2) : 136-41
Nyhlin, N; Anan, Intissar; El, Salhy M; et al.
2001
Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy.
Acta Neuropathologica
, Vol. 102, (3) : 227-32
Anan, Intissar; El-salhy, M; Ando, Y; et al.
2001
Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients.
Scandinavian Journal of Clinical and Laboratory Investigation
, Vol. 61, (1) : 11-8
Suhr, Ole B; Lång, K; Wikström, L; et al.
2000
Liver transplantation restores endocrine cells in patients with familial amyloidotic polyneuropathy.
Transplantation
, Vol. 70, (5) : 794-9
Anan, Intissar; El-Salhy, M; Nyhlin, N; et al.
2000
Heart failure caused by a novel amyloidogenic mutation of the transthyretin gene: ATTR Ala45Ser.
Amyloid: Journal of Protein Folding Disorders
, Vol. 7, (2) : 137-40
Janunger, T; Anan, Intissar; Holmgren, G; et al.
View publications in DiVA
Research projects
1 January 2019
Pathogenesis, diagnostics and treatment of transthyretin amyloidosis
Published: 07 Feb, 2019
WCMM grants postdoctoral Fellowships at the Faculty of Medicine
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