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Jun Zhang

I am a postdoc in Yaowen Wu’s group. My research focus on development of chemo-optogenetic system with photoswitchable CIDs enabling control of cellular processes by light.

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Affiliation
Postdoctoral fellow at Department of Chemistry
Location
KB.A4, Linnaeus väg 10 Umeå universitet, 901 87 Umeå

I completed my Ph.D. in Chemistry at Linköping University under the direction of Professor Per Hammarstrom and Peter Konradsson. During my Ph.D. study, I have done much research work, mainly focusing on synthesis and characterization of fluorescent stilbene-based probes for detection and imaging of disease-associated protein aggregates, especially Aβ and tau aggregates in Alzheimer’s disease.

In 2019, I joined Yaowen Wu lab as a postdoc. My current research focuses on development of chemo-optogenetic system with photoswitchable CIDs (sCIDs) that can undergo multiple rounds of light-induced dimerization, enabling reversible control of cellular processes by light. We use this system to reversibly control protein dimerization, protein localization, positioning of organelles and protein degradation in live cells with light. We envision the chemo-optogenetic approaches using sCIDs could be very useful to dissect the complexity of biological regulatory networks.

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