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Karolina Kauppi

I study biological mechanisms of cognitive impairments in aging and neuropsychiatric diseases.


Research qualifications: Docent



Works at

Research fellow at Department of Medical and Translational Biology Section: Group Lars Nyberg
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå
Affiliated as research fellow at Department of Clinical Sciences Section: Psychiatry
Norrlands universitetssjukhus, Umeå universitet, Klinisk vetenskap Umeå universitet, Klinisk vetenskap, 901 85 Umeå

Currently (may 2023) looking for a PhD student - please contact me for more information!

My current primary research project, funded by VR, Umeå University, and Karolinska Institutet, is focused onthe interplay between inherited risk factors and inflammatory factors for the risk of developing cognitive impairment and dementia in aging.

Normal aging is associated with changes in the brain that cause many cognitive abilities, such as memory, to decline in most people, but the individual variations are large! While some maintain very good cognitive ability in old age, others undergo more severe declines. Both individual variations within the framework of normal aging and the risk of developing dementia, or pathological aging, have a significant genetic component with a complex inheritance pattern. The project aims to identify the mechanisms through which genes act and how they interact with other factors such as gender and environmental factors.

In my research, I analyze data from the Betula project in Umeå where people's cognitive abilities, health, and brain structure have been followed for a long time, as well as the Swedish Twin Registry at the Karolinska Institutet, and the international open database UK Biobank. In this project, I link genetic factors for Alzheimer's disease with results from cognitive tests, biomarkers in blood for inflammation, and measures of brain structure and function that have been developed using functional magnetic resonance imaging.

Increased understanding of the biological processes underlying how our brains age can then be used to develop better drugs and treatments.

I also have an interest in psychiatric genetics and in previous projects have studied the genetic relationship between schizophrenia and cognition.


Group members:

Lovisa Larsson, Bachelor student, spring 2023

Adil Supiyev, postdoc, 2020-2023

Elise Koch, PhD-student (main supervisor),  2018-2022
Sofia Håglin, postdoc, 2018-2020



I am a member of the Young Academy of Sweden:


Interview about my research for SVT's "Meeting with":



Scientific Reports, Springer Nature 2023, Vol. 13, (1)
Håglin, Sofia; Koch, Elise; Schäfer Hackenhaar, Fernanda; et al.
Pharmacoepidemiology and Drug Safety, John Wiley & Sons 2023, Vol. 32, (4) : 446-454
Koch, Elise; Johnell, Kristina; Kauppi, Karolina
Progress in Neuro-psychopharmacology and Biological Psychiatry, Elsevier 2023, Vol. 20
Koch, Elise; Kauppi, Karolina; Chen, Chi-Hua
Journal of Alzheimer's Disease, IOS Press 2023, Vol. 94, (4) : 1443-1464
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Neurobiology of Aging, Elsevier 2023, Vol. 126 : 103-112
Supiyev, Adil; Karlsson, Robert; Wang, Yunzhang; et al.
Genes, MDPI 2022, Vol. 13, (3)
Koch, Elise; Nyberg, Lars; Lundquist, Anders; et al.
Translational Psychiatry, Springer Nature 2021, Vol. 11, (1)
Koch, Elise; Nyberg, Lars; Lundquist, Anders; et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, Oxford University Press 2021, Vol. 76, (6) : 955-963
Pudas, Sara; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Alzheimer's Research & Therapy, BioMed Central (BMC) 2021, Vol. 13
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Translational Psychiatry, Nature Publishing Group 2020, Vol. 10, (1)
Kauppi, Karolina; Rönnlund, Michael; Nordin Adolfsson, Annelie; et al.
Schizophrenia Research, Elsevier 2020, Vol. 222 : 167-174
Koch, Elise; Rosenthal, Brin; Lundquist, Anders; et al.
Schizophrenia Bulletin, Oxford University Press 2020, Vol. 46 : S28-S28
Koch, Elise; Rosenthale, Brin; Lundquist, Anders; et al.
Ageing Research Reviews, Elsevier 2020, Vol. 64
Nyberg, Lars; Boraxbekk, Carl-Johan; Eriksson Sörman, Daniel; et al.
European Neuropsychopharmacology, ELSEVIER 2019, Vol. 29 : S27-S27
Kauppi, Karolina; Gani, Osman; Sanyal, Nilotpal; et al.
Neurobiology of Aging, Elsevier 2019, Vol. 84 : 243.e1-243.e9
Lo, Min-Tzu; Kauppi, Karolina; Fan, Chun-Chieh; et al.
Bioinformatics, Oxford University Press 2019, Vol. 35, (1) : 1-11
Sanyal, Nilotpal; Lo, Min-Tzu; Kauppi, Karolina; et al.
American Journal of Psychiatry, AMER PSYCHIATRIC PUBLISHING, INC 2018, Vol. 175, (7) : 674-682
Kauppi, Karolina; Brin Rosenthal, Sara; Lo, Min-Tzu; et al.
Frontiers in Neuroscience, Frontiers Media S.A. 2018, Vol. 12
Kauppi, Karolina; Fan, Chun Chieh; McEvoy, Linda K.; et al.
Brain, behavior, and immunity, Vol. 61 : 209-216
Athanasiu, Lavinia; Giddaluru, Sudheer; Fernandes, Carla; et al.
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Chen, Chi-Hua; Wang, Yunpeng; Lo, Min-Tzu; et al.
Genetic Epidemiology, John Wiley & Sons 2017, Vol. 41, (7) : 706-707
Lo, Min-Tzu; Fan, Chun-Chieh; Kauppi, Karolina; et al.
Nature Genetics, Vol. 49, (1) : 152-156
Lo, Min-Tzu; Hinds, David A.; Tung, Joyce Y.; et al.
Human Molecular Genetics, OXFORD UNIV PRESS 2017, Vol. 26, (22) : 4530-4539
Lo, Min-Tzu; Wang, Yunpeng; Kauppi, Karolina; et al.
JAMA psychiatry, American Medical Association 2017, Vol. 74, (10) : 1065-1075
Smeland, Olav B.; Frei, Oleksandr; Kauppi, Karolina; et al.
European Neuropsychopharmacology, ELSEVIER SCIENCE BV 2017, Vol. 27 : S410-S410
Smeland, Olav B.; Kauppi, Karolina; Wang, Yunpeng; et al.
Psychiatry Research: Neuroimaging, Elsevier 2014, Vol. 222, (1-2) : 60-66
Fernandes, Carla Patricia Duarte; Westlye, Lars Tjelta; Giddaluru, Sudheer; et al.
NeuroImage, Vol. 89, (1) : 306-313
Kauppi, Karolina; Nilsson, Lars-Göran; Persson, Jonas; et al.
Journal of cognitive neuroscience, Vol. 26, (4) : 746-754
Nyberg, Lars; Andersson, Micael; Kauppi, Karolina; et al.
Umeå University medical dissertations, 1580
Kauppi, Karolina
Neuropsychologia, Elsevier 2013, Vol. 51, (12) : 2462-2468
Kauppi, Karolina; Nilsson, Lars-Göran; Adolfsson, Rolf; et al.
Journal of cognitive neuroscience, Vol. 25, (Suppl.) : S140-S141
Kauppi, Karolina; Nilsson, Lars-Göran; Adolfsson, Rolf; et al.
Cerebral Cortex, New York, NY: Oxford University Press 2012, Vol. 22, (10) : 2297-2304
Persson, Jonas; Pudas, Sara; Lind, Johanna; et al.
Journal of Neuroscience, Society for Neuroscience 2011, Vol. 31, (40) : 14218-14222
Kauppi, Karolina; Nilsson, Lars-Göran; Adolfsson, Rolf; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, (52) : 22682-22686
Nyberg, Lars; Salami, Alireza; Andersson, Mikael; et al.

Research groups

Group member

I teach physiology.