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Staff photo Katarina Olofsson

Katarina Olofsson

My research group study virus in upper airway. Human papillomavirus can be linked to cancer of tongue base and tonsils as well as warts in the throat. Epstein-Barr virus for cancer behind the nose.

Contact

E-mail
Location
Umeå universitet, Klinisk vetenskap, 901 85 Umeå

Works at

Affiliation
Affiliated as research fellow at Department of Clinical Sciences Units: Otorhinolaryngology
Affiliation
Adjunct associate professor at Department of Clinical Sciences Units: Otorhinolaryngology
Affiliation
Adjunct professor at Department of Clinical Sciences Units: Otorhinolaryngology

I am employed at Region Västerbotten as chief physician and adjunct lecturer/associate professor. I teach/supervise at the program for medicine, speech therapy, and nursing as well as ST education. I meet patients with voice, respiratory and swallowing disorders at surgery and reception. The research line is translational, interactive and collaborative. Our research group includes laboratory expertise, clinical expertise in virology, pathology, ear, nose and throat diseases, and statistics. We represent two educational nodes in the northern region and collaborate with all university hospitals nationally, both clinically and in terms of research.

Supervisor history

Principal supervisor for doctoral students

  • In October 2016, Christos Loizou “Human papillomavirus in recurrent respiratory papillomatosis, tonsillar and mobile tongue cancer”
  • In May 2019, Anna Holm “Human papillomavirus in sino-nasal inverted papilloma, recurrent respiratory papilloma and non-malignant tonsils”.
  • In November 2022, Alexandra Schindele will defend her thesis.
  • In January 2021, Anders Erlandsson was registered as a doctoral student "Airway stenosis - in relation to surgical technique, causation and impact on quality of life"
  • In February 2017, Stina Sundstedt “Swallowing function in patients with Parkinson's disease and Deep Brain Stimulation”. Stina graduated with a licentiate degree in April 2014

Assistant supervisor for doctoral students

  • Eleonor Koro, registered doctoral student in November 2019.
  • Elenor Lundgren, registered doctoral student in September 2020

Future projects

What?

We want to study airway stenosis in the context of treatment, viruses and the impact on quality of life. We have been reporting data on respiratory viruses for many years

Why?

The overall purpose is patient and population benefit. We study the upper airway in relation to viruses. Human papillomavirus (HPV) can be linked to cancer of the tongue base and tonsils and warts in the throat (respiratory papilloma, RRP). Epstein-Barr have a relationship to cancer behind the nose. P16 is a site-specific tumor marker for HPV, which inhibits tumor growth, EBV can down-regulate p16. We do not know the role of these viruses in various places in the upper respiratory tract; drivers or passengers. Subglottic stenosis (SGS) is an upper airway stenosis, about 1 cm below the vocal cords, and occurs in 1 in 400,000 cases / year. Unknown cause. Our research group reports a high incidence of EBV (33%) in vocal cord cancer. RRP is due to infection with HPV6 and 11 in the throat usually on the vocal cords. Some cases in both RRP and SGS, develop chronic infection/inflammation with a recurrent need for surgical treatment.

Hypothesis

There is virus in SGS, balloon dilation is a better treatment option than laser and patients show significantly improved breathing and quality of life after surgery.

Clinical benefit

Outcomes will influence the choice of surgical method at SGS especially in the light of our parallel quality of life study. If we find viruses in SGS, we can use existing vaccines against e.g. HPV to extend treatment intervals, such as the case with respiratory papilloma (RRP). We expect a reduced incidence if HPV is present in SGS, since there is an ongoing gender-neutral vaccination. We can also more effectively protect healthcare professionals during surgery if we know where the virus is.

European Journal of Immunology, John Wiley & Sons 2021, Vol. 51, (10) : 2535-2539
Sobti, Aastha; Sakellariou, Christina; Nilsson, Maile; et al.
European Annals of Otorhinolaryngology, Head and Neck Diseases, Elsevier Masson SAS 2020, Vol. 137, (3) : 201-206
Holm, Anna; Allard, Annika; Eriksson, Irene; et al.
Acta Oto-Laryngologica, Taylor & Francis 2020, Vol. 140, (5) : 413-417
Schindele, Alexandra; Holm, Anna; Nylander, Karin; et al.
Laryngoscope Investigative Otolaryngology, Wiley-Blackwell 2019, Vol. 4, (3) : 285-291
Holm, Anna; Schindele, Alexandra; Allard, Annika; et al.
Journal of Voice, Elsevier 2019, Vol. 33, (4) : 545-549
Karlsson, Fredrik; Malinova, Elin; Olofsson, Katarina; et al.
Acta Oto-Laryngologica, Taylor & Francis 2018, Vol. 138, (11) : 1020-1027
Holm, Anna; Hellman, Urban; Laurent, Claude; et al.
Abstracts from the Scandinavian Society of Anesthesiology and Intensive Care Medicine 34th Congress, John Wiley & Sons 2017 : 1034-1035
Nellgård, Per; Ejnell, Hasse; Olofsson, Katarina; et al.
Brain and Behavior, John Wiley & Sons 2017, Vol. 7, (6)
Sundstedt, Stina; Holmén, Lina; Rova, Elin; et al.
Annals of Otology, Rhinology and Laryngology, Vol. 126, (2) : 110-116
Sundstedt, Stina; Nordh, Erik; Linder, Jan; et al.
PLOS ONE, Vol. 12, (9)
Wilms, Torben; Khan, Gulfaraz; Coates, Philip J; et al.
The Laryngoscope, Vol. 126, (1) : 122-127
Forslund, Ola; Schwartz, Stefan; Olofsson, Katarina; et al.
Scientific Reports, Vol. 6
Gu, Xiaolian; Boldrup, Linda; Coates, Philip J; et al.
Acta Oto-Laryngologica, Vol. 135, (10) : 1058-1064
Loizou, Christos; Laurell, Göran; Arvidsson, Andreas; et al.
Oncology Letters, Spandidos Publications 2015, Vol. 10, (6) : 3565-3572
Loizou, Christos; Laurell, Göran; Lindquist, David; et al.
British Journal of Cancer, Nature Publishing Group 2015, Vol. 113, (2) : 321-326
Sgaramella, Nicola; Coates, P. J.; Strindlund, K.; et al.
Journal of Speech, Language and Hearing Research, Vol. 57 : 1178-1190
Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; et al.
Acta Oto-Laryngologica, Informa Healthcare 2014, Vol. 134, (4) : 401-406
Loizou, Christos; Laurell, Göran; Lindquist, David; et al.
Acta Neurologica Scandinavica, Wiley-Blackwell 2014, Vol. 130, (1) : 27-33
Louise, Johansson; Sofia, Möller; Olofsson, Katarina; et al.
Journal of Speech, Language and Hearing Research, American Speech-Language-Hearing Association 2013, Vol. 56, (1) : 150-158
Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; et al.
Acta Neurologica Scandinavica, Hoboken: Wiley-Blackwell 2013, Vol. 127, (5) : 329-336
Kulneff, Linda; Sundstedt, Stina; Olofsson, Katarina; et al.
Parkinsonism & Related Disorders, Elsevier 2012, Vol. 18, (7) : 824-827
Karlsson, Fredrik; Blomstedt, Patric; Olofsson, Katarina; et al.
Acta Neurologica Scandinavica, John Wiley & Sons 2012, Vol. 126, (5) : 350-356
Sundstedt, Stina; Olofsson, Katarina; van Doorn, Jan; et al.
Parkinson’s Disease, Hindawi Publishing Corporation 2011, Vol. 2011 : 658956-
Lundgren, Sofie; Saeys, Thomas; Karlsson, Fredrik; et al.
Läkartidningen, Vol. 108, (21) : 1187-1189
Olofsson, Katarina; Loizou, Christos; Evander, Magnus; et al.
Läkartidningen, Stockholm: Läkartidningen Förlag AB 2010, Vol. 107, (17) : 1150-1154
Olofsson, Katarina; Van Doorn, Jan; Kulneff, Linda; et al.
Journal of Immunology, Vol. 185, (1) : 345-356
Teige, Anna; Bockermann, Robert; Hasan, Maruf; et al.
Journal of Immunology, Vol. 184, (5) : 2253-2260
Zhao, Ming; Wigren, Maria; Dunér, Pontus; et al.
Journal of Lipid Research, Vol. 50, (11) : 2258-2264
Diczfalusy, Ulf; Olofsson, Katarina E; Carlsson, Ann-Margreth; et al.
Current Opinion in Lipidology, Vol. 20, (1) : 82-84
Olofsson, Katarina E; Björkbacka, Harry
Circulation Research, Vol. 104, (12) : e62-70
Wigren, Maria; Bengtsson, Daniel; Dunér, Pontus; et al.
Biochemical and Biophysical Research Communications - BBRC, Vol. 370, (2) : 348-352
Olofsson, Katarina E; Andersson, Linda; Nilsson, Jan; et al.
The Laryngoscope, Vol. 112, (12) : 2211-2219
Hertegård, Stellan; Hallén, Lars; Laurent, Claude; et al.
Annals of Otology, Rhinology and Laryngology, Vol. 109, (5) : 488-496
Olofsson, Katarina; Hellström, S; Hammarström, Marie-Louise
Acta Oto-Laryngologica, Vol. 119, (6) : 712-717
Olofsson, Katarina; Mattsson, C; Hammarström, Marie-Louise; et al.
Clinical and Experimental Immunology, Vol. 111, (1) : 36-47
Olofsson, Katarina; Hellström, S; Hammarström, Marie-Louise
Clinical and Experimental Immunology, Vol. 106, (2) : 396-403
Olofsson, Katarina; Hellström, S; Hammarström, Marie-Louise
Olofsson, Katarina; Sjöstedt, M; Allard, Annika; et al.

Research groups

Head of research
Katarina Olofsson

I teach/supervise at the program for medicine, speech therapy, and nursing as well as ST education.