My research group study virus in upper airway. Human papillomavirus can be linked to cancer of tongue base and tonsils as well as warts in the throat. Epstein-Barr virus for cancer behind the nose.
I am employed at Region Västerbotten as chief physician and adjunct lecturer/associate professor. I teach/supervise at the program for medicine, speech therapy, and nursing as well as ST education. I meet patients with voice, respiratory and swallowing disorders at surgery and reception. The research line is translational, interactive and collaborative. Our research group includes laboratory expertise, clinical expertise in virology, pathology, ear, nose and throat diseases, and statistics. We represent two educational nodes in the northern region and collaborate with all university hospitals nationally, both clinically and in terms of research.
Principal supervisor for doctoral students
Assistant supervisor for doctoral students
We want to study airway stenosis in the context of treatment, viruses and the impact on quality of life. We have been reporting data on respiratory viruses for many years
The overall purpose is patient and population benefit. We study the upper airway in relation to viruses. Human papillomavirus (HPV) can be linked to cancer of the tongue base and tonsils and warts in the throat (respiratory papilloma, RRP). Epstein-Barr have a relationship to cancer behind the nose. P16 is a site-specific tumor marker for HPV, which inhibits tumor growth, EBV can down-regulate p16. We do not know the role of these viruses in various places in the upper respiratory tract; drivers or passengers. Subglottic stenosis (SGS) is an upper airway stenosis, about 1 cm below the vocal cords, and occurs in 1 in 400,000 cases / year. Unknown cause. Our research group reports a high incidence of EBV (33%) in vocal cord cancer. RRP is due to infection with HPV6 and 11 in the throat usually on the vocal cords. Some cases in both RRP and SGS, develop chronic infection/inflammation with a recurrent need for surgical treatment.
There is virus in SGS, balloon dilation is a better treatment option than laser and patients show significantly improved breathing and quality of life after surgery.
Outcomes will influence the choice of surgical method at SGS especially in the light of our parallel quality of life study. If we find viruses in SGS, we can use existing vaccines against e.g. HPV to extend treatment intervals, such as the case with respiratory papilloma (RRP). We expect a reduced incidence if HPV is present in SGS, since there is an ongoing gender-neutral vaccination. We can also more effectively protect healthcare professionals during surgery if we know where the virus is.
I teach/supervise at the program for medicine, speech therapy, and nursing as well as ST education.