Kristoffer Sahlholm

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Assistant professor at Department of Integrative Medical Biology (IMB) Units: Group Kristoffer Sahlholm, Teachers D1-wing

hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Affiliated as other position at Wallenberg Centre for Molecular Medicine at Umeå University (WCMM)

Umeå universitet, 901 87 Umeå

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Frontiers in Pharmacology, Frontiers Media S.A. 2023, Vol. 14

Burström, Viktor; Ågren, Richard; Betari, Nibal; et al.

Unique effect of clozapine on adenosine A_2A-dopamine D₂ receptor heteromerization

Biomedicine and Pharmacotherapy, Elsevier 2023, Vol. 160

Valle-León, Marta; Casajuana-Martin, Nil; del Torrent, Claudia Llinas; et al.

TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT1A receptor agonist SEP-383856

Neuropsychopharmacology, Springer Nature 2022, Vol. 47 : 2319-2329

Saarinen, Marcus; Mantas, Ioannis; Flais, Ivana; et al.

Evidence for two modes of binding of the negative allosteric modulator SB269,652 to the dopamine D2 receptor

Biomedicines, MDPI 2022, Vol. 10, (1)

Ågren, Richard; Sahlholm, Kristoffer

Synthetic corticosteroids as tryptophan hydroxylase stabilizers

Future Medicinal Chemistry, Future Science Ltd. 2021, Vol. 13, (17) : 1465-1474

Betari, Nibal; Teigen, Knut; Sahlholm, Kristoffer; et al.

Interaction of ligands for pet with the dopamine d3 receptor: in silico and in vitro methods

Biomolecules, MDPI 2021, Vol. 11, (4)

Hsieh, Chia-Ju; Riad, Aladdin; Lee, Ji Youn; et al.

Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects

British Journal of Pharmacology

López-Cano, Marc; Font, Joan; Aso, Ester; et al.

V374A KCND3 Pathogenic Variant Associated With Paroxysmal Ataxia Exacerbations

Neurology Genetics, American Academy of Neurology 2021, Vol. 7, (1)

Paucar, Martin; Ågren, Richard; Li, Tianyi; et al.

Mechanistic insights into dopaminergic and serotonergic neurotransmission: concerted interactions with helices 5 and 6 drive the functional outcome

Chemical Science, Royal Society of Chemistry 2021, Vol. 12, (33) : 10990-11003

Stepniewski, Tomasz Maciej; Mancini, Arturo; Ågren, Richard; et al.

Decreased striatal adenosine A_2A-dopamine D₂ receptor heteromerization in schizophrenia

Neuropsychopharmacology, Springer Nature 2021, Vol. 46 : 665-672

Valle-Leon, Marta; Callado, Luis F.; Aso, Ester; et al.

G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D₂ receptor desensitization

The FASEB Journal, John Wiley & Sons 2021, Vol. 35, (11)

Ågren, Richard; Sahlholm, Kristoffer

Dopamine d₂ receptor agonist binding kinetics: role of a conserved serine residue

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (8)

Ågren, Richard; Stepniewski, Tomasz Maciej; Zeberg, Hugo; et al.

Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis

Future Medicinal Chemistry, Future Science 2020, Vol. 12, (16) : 1461-1474

Betari, Nibal; Sahlholm, Kristoffer; Ishizuka, Yuta; et al.

Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole-In Vitro and In Vivo Investigations

Frontiers in Pharmacology, Frontiers Media S.A. 2020, Vol. 11

Betari, Nibal; Sahlholm, Kristoffer; Morato, Xavier; et al.

A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans

Current Biology, Elsevier 2020, Vol. 30, (17) : 3465-3469

Zeberg, Hugo; Dannemann, Michael; Sahlholm, Kristoffer; et al.

Voltage-Dependent Dopamine Potency at D-1-Like Dopamine Receptors

Frontiers in Pharmacology, Frontiers Media S.A. 2020, Vol. 11

Ågren, Richard; Sahlholm, Kristoffer

Ligand with Two Modes of Interaction with the Dopamine D-2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism

ACS Chemical Neuroscience, American Chemical Society (ACS) 2020, Vol. 11, (19) : 3130-3143

Ågren, Richard; Zeberg, Hugo; Stępniewski, Tomasz Maciej; et al.

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Research groups

Head of research

Kristoffer Sahlholm-research group