Tick-borne encephalitis virus (TBEV) is a dangerous, emerging pathogen that causes large-scale changes in the host membranes to produce the next generation of virions, yet these processes are poorly understood. As a postdoc in Professor Richard Lundmark lab, I study them by reconstituting the membrane remodelling events using recombinant proteins and artificial lipid models and characterizing them with cryogenic electron microscopy (cryo-EM) and other advanced structural biology methods. The aim of my work is to understand fundamental biological processes in atomic detail, but also to provide targets for future medical interventions.
I did my PhD work at the University of Helsinki in Professor Sarah Butcher’s group. I focused on the structural details of the TBEV virion as well as its assembly and maturation processes. We solved the cryo-EM structures of both mature and immature TBEV, and I investigated the role of different lipid species in the very early stages of virion assembly.
In my free time I enjoy skateboarding, miniature wargames, birdwatching, and comics.