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Magnus Hultdin

Associate Professor and Senior Consultant in Pathology

Head of Department - Department of Medical Biosciences

Research qualifications: Docent

Works at

Affiliation
Associate professor, senior consultant (attending) physician at Department of Medical Biosciences Section: Pathology Role: Head of department
Location
By 6M, vån 1, Sjukhusområdet Umeå universitet, 901 85 Umeå

The telomeres are located at the ends of the chromosomes and shortens when the cells divide.After many cell divisions, the telomeres become significantly shorter and as a consequence the cells stop  divideing. In cells that have a great need to proliferate (eg stem cells), the enzyme telomerase counteracts the loss of telomeres and this enzyme is also seen in cancer.

One focus for our research group is the significance of telomere changes and epigenetics in cellular aging, especially in Telomere Biology Disorders (TBD). In TBD, patients have mutations in genes for telomerase telomere-binding proteins with increased loss of telomeres. In TBD the patients have bone marrow failure, leukemias, pulmonary fibrosis and problems with the skin, nails and mucous membranes. We hope that with our research we can contribute to increased knowledge of cellular aging and that it can contribute to improved treatment of TBD patients in the future but also to an increased understanding of aging processes in cancer cells.

Another part of our research focuses on factors that affect tumor development and prognosis in lymphatic leukemia and lymphoma. We mainly study genetic, epigenetic and telomer biological factors in aggressive lymphatic leukemia and lymphoma. In many cases, these diseases have a good prognosis after treatment, but a significant proportion of patients relapse and die in their disease. We have previously studied the prognostic significance of DNA methylation changes in acute lymphatic leukemia and in the current projects we focus mainly on aggressive B-cell lymphomas, which are the most common form of lymphoma. Hopefully our research will to contribute to an increased understanding of why some patients with lymphatic leukemia and lymphoma get relapses. Furthermore we aim to identify markers that can improve treatment and prognosis for the patients with lymphatic leukemia and lymphoma.

Scientific Reports, Springer Nature 2023, Vol. 13, (1)
Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.
Blood, Elsevier 2023, Vol. 142, (16) : 1399-1403
Kolijn, P. Martijn; Späth, Florentin; Khouja, Mouhamad; et al.
Journal of Alzheimer's Disease, IOS Press 2023, Vol. 94, (4) : 1443-1464
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Journal of Clinical Immunology, Springer 2022, Vol. 42 : 618-633
Framme, Jenny Lingman; Lundqvist, Christina; Lundell, Anna-Carin; et al.
Blood, American Society of Hematology 2022, Vol. 139, (10) : 1557-1563
Kolijn, P. Martijn; Hosnijeh, Fatemeh Saberi; Späth, Florentin; et al.
Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
Frontiers in Immunology, Frontiers Media S.A. 2021, Vol. 11
Dernstedt, Andy; Leidig, Jana; Holm, Anna; et al.
Leukemia, Springer Nature 2021, Vol. 35, (7) : 1894-1906
Modvig, S.; Hallböök, H.; Madsen, H. O.; et al.
Acta Oncologica, Taylor & Francis Group 2021, Vol. 60, (9) : 1218-1224
Patthey, Annika; Boman, Karin; Tavelin, Björn; et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, Oxford University Press 2021, Vol. 76, (6) : 955-963
Pudas, Sara; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Alzheimer's Research & Therapy, BioMed Central (BMC) 2021, Vol. 13
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
American Journal of Hematology, Wiley-Blackwell 2020, Vol. 95, (1) : 57-67
Abdulla, Maysaa; Hollander, Peter; Pandzic, Tatjana; et al.
Journal of Translational Medicine, Vol. 18, (1)
Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.
Blood Cancer Journal, Nature Publishing Group 2020, Vol. 10, (4)
Haider, Zahra; Landfors, Mattias; Golovleva, Irina; et al.
Pediatric Research, Nature Publishing Group 2020, Vol. 88
Henckel, Ewa; Landfors, Mattias; Haider, Zahra; et al.
British Journal of Haematology, Wiley-Blackwell Publishing Inc. 2020, Vol. 189, (4) : 707-717
Menter, Thomas; Tzankov, Alexandar; Zucca, Emanuele; et al.
Leukemia, Nature Publishing Group 2020, Vol. 34, (2) : 347-357
Quist-Paulsen, P.; Toft, N.; Heyman, M.; et al.
Cancer Medicine, John Wiley & Sons 2019, Vol. 8, (1) : 311-324
Haider, Zahra; Larsson, Pär; Landfors, Mattias; et al.
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Kolan, Shrikant S; Lidström, Tommy; Mediavilla, Tomás; et al.
Clinical Epigenetics, BioMed Central 2018, Vol. 10
Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; et al.
Acta Oncologica, Taylor & Francis 2018, Vol. 57, (2) : 187-194
Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; et al.
European Journal of Human Genetics, Nature Publishing Group 2018, Vol. 26, (6) : 858-867
Norberg, Anna; Rosén, Anna; Raaschou-Jensen, Klas; et al.
Neurobiology of Aging, Elsevier 2017, Vol. 55 : 167-171
Degerman, Sofie; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Scandinavian Journal of Immunology, John Wiley & Sons 2017, Vol. 86, (4) : 343-343
Kolan, Shrikant S.; Lidström, Tommy; Björk, Karl; et al.
Pediatric Blood & Cancer, Vol. 63, (7) : 1185-1192
Borssén, Magnus; Haider, Zahra; Landfors, Mattias; et al.
Blood, Vol. 128, (23) : 2666-2670
Mansouri, Larry; Noerenberg, Daniel; Young, Emma; et al.
Pediatric Blood & Cancer, Vol. 62, (6) : 951-956
Ranta, Susanna; Nilsson, Frans; Harila-Saari, Arja; et al.
PLOS ONE, Public library of science 2010, Vol. 5, (7) : e11552-
Forsberg, Karin; Jonsson, P Andreas; Andersen, Peter M; et al.
Medical Oncology, Vol. 27, (3) : 618-623
Sundström, Gunnel; Hultdin, Magnus; Engström-Laurent, Anna; et al.
Med Oncol, Vol. 24, (1) : 63-70
Hultdin, Magnus; Sundström, Gunnel; Wahlin, Anders; et al.
Blood, Vol. 105, (12) : 4807-4812
Grabowski, Pawel; Hultdin, Magnus; Karlsson, Karin; et al.
Medical Oncology, Vol. 22, (1) : 71-78
Sundström, Gunnel; Dahl, Inger Marie S; Hultdin, Magnus; et al.
Haematologica, Vol. 90, (4) : 465-469
Tobin, Gerard; Thunberg, Ulf; Laurell, Anna; et al.
British Journal of Cancer, London: Nature Publishing Group 2003, Vol. 88, (4) : 593-598
Hultdin, Magnus; Rosenquist, R; Thunberg, U; et al.
Experimental Cell Research, Elsevier 2001, Vol. 271 : 223-229
Hultdin, Magnus; Grönlund, Elisabeth; Norrback, Karl-Fredrik; et al.
European Journal of Haematology, Blackwell Munksgaard 2001, Vol. 67, (5-6) : 309-317
Norrback, Karl-Fredrik; Hultdin, Magnus; Dahlenborg, Katarina; et al.
Nucleic Acids Research, Oxford: Oxford University Press 1998, Vol. 26, (16) : 3651-3656
Hultdin, Magnus; Grönlund, Elisabeth; Norrback, Karl-Fredrik; et al.

Research groups

Head of research
Magnus Hultdin Lab