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Staff photo Magnus Andersson

Magnus Andersson

In my lab, we use both experimental (time-resolved X-ray scattering) and computational (MD simulations) techniques to understand membrane protein functionality.

Contact

E-mail
magnus.p.andersson@umu.se
Phone
+46 90 786 57 56

Works at

Affiliation
Associate professor at Department of Chemistry
Location
KB.A3, Linnaeus väg 10, (rum: A3.07.01) Umeå universitet, 901 87 Umeå

We combine experimental and computational methods to determine membrane protein dynamics. Specifically, we use and develop time-resolved solution X-ray scattering and different molecular dynamic simulation techniques. We focus on primary and secondary active transport with the main target proteins: P-type ATPases & lactose permease, but also many others. The aim is to understand the underlying structural dynamics encoded in the amino acid sequence that enable function.

Website (including full list of publications): https://www.biostruct.umu.se/principal-investigators/magnus-andersson/

2020
State-Dependent and Mutation-Induced Differences in Protein-Lipid Interactions in the Na,K Atpase
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 497A-497A
Mahato, Dhani R.; Andersson, Magnus
2020
Mapping the Adenylate Kinase Reaction by Time-Resolved X-ray Solution Scattering
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 50A-50A
Ravishankar, Harsha; Goodman, Jack; Nors Pedersen, Martin; et al.
2020
Tracking Ca2+ ATPase intermediates in real time by x-ray solution scattering
Science Advances, American Association for the Advancement of Science 2020, Vol. 6, (12)
Ravishankar, Harsha; Pedersen, Martin Nors; Eklund, Mattias; et al.
2020
Tracking Ca2+ ATPase Intermediates in Real-time by X-Ray Solution Scattering
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 26A-26A
Ravishankar, Harsha; Pedersen, Martin Nors; Sitsel, Alya; et al.
2019
Structure of the human ClC-1 chloride channel
PLoS biology, Public Library Science 2019, Vol. 17, (4)
Wang, Kaituo; Preisler, Sarah Spruce; Zhang, Liying; et al.
2018
Uptake dynamics in the Lactose permease (LacY) membrane protein transporter
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Kimanius, D.; Lindahl, E.; Andersson, Magnus
2018
Probing the activity of a recombinant Zn2+-transporting P-type ATPase
Biopolymers, John Wiley & Sons 2018, Vol. 109, (2)
Ravishankar, Harsha; Barth, Andreas; Andersson, Magnus
2016
Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport
Biophysical Journal, Elsevier 2016, Vol. 111, (11) : 2417-2429
Grønberg, Christina; Sitsel, Oleg; Lindahl, Erik; et al.
2016
Thermodynamics of Nanobody Binding to Lactose Permease
Biochemistry, American Chemical Society (ACS) 2016, Vol. 55, (42) : 5917-5926
Hariharan, Parameswaran; Andersson, Magnus; Jiang, Xiaoxu; et al.
2016
Role of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY
Biochemistry, American Chemical Society (ACS) 2016, Vol. 55, (31) : 4326-4332
Jiang, X.; Andersson, Magnus; Chau, B. T.; et al.
2016
Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2016, Vol. 113, (43) : E6696-E6703
Nys, Mieke; Wijckmans, Eveline; Farinha, Ana; et al.
2016
The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel
PloS Computational Biology, PLOS 2016, Vol. 12, (1)
Yazdi, Samira; Stein, Matthias; Elinder, Fredrik; et al.
2015
SAXS-Guided Metadynamics
Journal of Chemical Theory and Computation, Vol. 11, (7) : 3491-3498
Kimanius, Dari; Pettersson, Ingrid; Schluckebier, Gerd; et al.
2015
Conformational Gating Dynamics in the GluCl Anion-Selective Chloride Channel
ACS Chemical Neuroscience, American Chemical Society (ACS) 2015, Vol. 6, (8) : 1459-1467
Yoluk, Özge; Lindahl, Erik; Andersson, Magnus
2014
Galactoside-binding site in LacY
Biochemistry, Vol. 53, (9) : 1536-1543
Jiang, X.; Villafuerte, M. K. R.; Andersson, Magnus; et al.
2014
Structure and mechanism of Zn2+-transporting P-type ATPases
Nature, Vol. 514, (7523) : 518-+
Wang, Kaituo; Sitsel, Oleg; Meloni, Gabriele; et al.
2013
Crystal Structure of Na+, K+-ATPase in the Na+-Bound State
Science, Vol. 342, (6154) : 123-127
Nyblom, Maria; Poulsen, Hanne; Gourdon, Pontus; et al.
2010
Light-Induced Structural Changes in a Photosynthetic Reaction Center Caught by Laue Diffraction
Science, Vol. 328, (5978) : 630-633
Wöhri, Annemarie B.; Katona, Gergely; Johansson, Linda C.; et al.
2008
A Proposed Time-Resolved X-Ray Scattering Approach to Track Localand Global Conformational Changes in Membrane Transport Proteins
Structure, Vol. 16 : 21-28
Andersson, Magnus; Vincent, Jonathan; van der Spoel, David; et al.
Permeability and ammonia selectivity in aquaporin TIP2;1: linking structure to function
Scientific Reports
Lindahl, Viveca; Gourdon, Pontus; Andersson, Magnus; et al.
View publications in DiVA