Mikael Brink

MD, PhD.

Assistant professor of Rheumatology

0000-0001-7675-3488

Contact

mikael.brink@umu.se

Works at

Assistant professor, resident physician at Department of Public Health and Clinical Medicine Section: Reumatology

Visiting address, view map

My research primarily focuses on rheumatoid arthritis, aiming to investigate various aspects of the disease's early development and its consequences, such as joint damage. By using blood samples collected before symptom onset, we have analysed both protein markers and auto-antibodies and found that several of these deviate in yet symptom free individuals compared to control-individuals from the population. Furthermore, some of these antibodies are also associated with an increased risk of joint damage. In addition to this, we are also working on mapping hereditary factors linked to rheumatoid arthritis.

Protein profiling in presymptomatic individuals separates myeloperoxidase-antineutrophil cytoplasmic antibody and proteinase 3-antineutrophil cytoplasmic antibody vasculitides

Arthritis & Rheumatology, Vol. 75, (6) : 996-1006

Brink, Mikael; Berglin, Ewa; Mohammad, Aladdin J.; et al.

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2022, Vol. 81, (8) : 1085-1095

Saevarsdottir, Saedis; Stefansdottir, Lilja; Sulem, Patrick; et al.

Dysregulated microRNA expression in rheumatoid arthritis families-a comparison between rheumatoid arthritis patients, their first-degree relatives, and healthy controls

Clinical Rheumatology, Springer 2021, Vol. 40, (6) : 2387-2394

Renman, Emma; Brink, Mikael; Ärlestig, Lisbeth; et al.

Antibodies against citrullinated peptides are associated with clinical and radiological outcomes in patients with early rheumatoid arthritis: a prospective longitudinal inception cohort study

RMD Open, BMJ Publishing Group Ltd 2019, Vol. 5, (2)

Boman, Antonia; Brink, Mikael; Lundquist, Anders; et al.

Protein Profiling and Network Enrichment Analysis in Individuals Before and After the Onset of Rheumatoid Arthritis

Arthritis & Rheumatology, John Wiley & Sons 2019, Vol. 71

Brink, Mikael; Lundquist, Anders; Alexeyenko, Andrey; et al.

Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Arthritis Research & Therapy, BioMed Central 2019, Vol. 21, (1)

Brink, Mikael; Lundquist, Anders; Alexeyenko, Andrey; et al.

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype

American Journal of Human Genetics, Cell Press 2019, Vol. 105, (3) : 616-624

Terao, Chikashi; Brynedal, Boel; Chen, Zuomei; et al.

Vitamin d in individuals before onset of rheumatoid arthritis: relation to vitamin d binding protein and its associated genetic variants

Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2018, Vol. 77 : 282-282

Brink, Mikael; Johansson, L.; Nygren, E.; et al.

Vitamin D in individuals before onset of rheumatoid arthritis: relation to vitamin D binding protein and its associated genetic variants

Scandinavian Journal of Rheumatology, Taylor & Francis 2018, Vol. 47 : 23-24

Brink, Mikael; Johansson, Linda; Nygren, E.; et al.

Triple positivity for anti–citrullinated protein autoantibodies, rheumatoid factor, and anti–carbamylated protein antibodies conferring high specificity for rheumatoid arthritis: implications for very early identification of at‐risk individuals

Arthritis & Rheumatology, Hoboken: John Wiley & Sons 2018, Vol. 70, (11) : 1721-1731

Verheul, Marije K.; Böhringer, Stefan; van Delft, Myrthe A. M.; et al.

Acpa against different citrullinated peptides identify specific phenotypes of rheumatoid arthritis

Annals of the Rheumatic Diseases, BMJ PUBLISHING GROUP 2017, Vol. 76 : 792-792

Brink, Mikael; Hansson, M.; Mathson-Alm, L.; et al.

An increased concentration of receptor activator of nuclear factor kappa-B ligand pre-dates the onset of rheumatoid arthritis

Rheumatology, Oxford University Press 2017, Vol. 56, (12) : 2190-2196

Johansson, Linda; Ärlestig, Lisbeth; Kokkonen, Heidi; et al.

Rheumatoid Factor Isotypes in Relation to Antibodies Against Citrullinated Peptides and Anti-Carbamylated Antibodies in Individuals Before the Onset of Rheumatoid Arthritis

Arthritis Research & Therapy, Vol. 18

Brink, Mikael; Hansson, M; Mathsson-Alm, L; et al.

Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis

Arthritis Research & Therapy, BioMed Central 2016, Vol. 18

Johansson, Linda; Pratesi, Federico; Brink, Mikael; et al.

Presence of immunological markers preceding the onset of rheumatoid arthritis

Umeå University medical dissertations, 1714

Brink, Mikael

Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage

Arthritis Research & Therapy, Vol. 17

Brink, Mikael; Verheul, Marije K.; Rönnelid, Johan; et al.

Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis

Arthritis Research & Therapy, BioMed Central 2015, Vol. 17

Kokkonen, Heidi; Brink, Mikael; Hansson, Monika; et al.

Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study

Arthritis Research & Therapy, Vol. 16, (1) : R45-

Bokarewa, Maria; Brink, Mikael; Erlandsson, Malin; et al.

The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides

Annals of the Rheumatic Diseases, Vol. 73, (7)

Brink, Mikael; Hansson, Monika; Ronnelid, Johan; et al.

The presence of anti-carbamylated protein antibodies prior to onset of symptoms of rheumatoid arthritis (RA) is associated with radiological progression in early RA

Scandinavian Journal of Rheumatology, Informa Healthcare 2014, Vol. 43, (Suppl. 127, Meeting Abstract: PP109) : 21-22

Brink, Mikael; Verheul, M. K.; Ronnelid, J.; et al.

Anti-carbamylated protein antibodies precede the onset of symptoms of rheumatoid arthritis in a Swedish biobank cohort

Annals of the Rheumatic Diseases, Vol. 73 : 397-398

Brink, Mikael; Verheul, M. K.; Ronnelid, J.; et al.

B Regulatory Cells are Functionally Impaired in Patients with Rheumatoid Arthritis and in Their First-Degree Relatives Compared with Controls

Scandinavian Journal of Immunology, Vol. 79, (6) : 450-450

Brink, Mikael; Ärlestig, Lisbeth; Rantapää-Dahlqvist, Solbritt; et al.

Survivin but NOT fms-like tyrosine kinase ligand (FLT3L) is up-regulated before onset of rheumatoid arthritis

Annals of the Rheumatic Diseases, Vol. 72, (Suppl. 3) : 193-193

Bokarewa, M; Brink, Mikael; Erlandsson, M; et al.

Survivin But Not Fms-Like Tyrosine Kinase Ligand Is Up-Regulated Before Onset Of Rheumatoid Arthritis

Arthritis and Rheumatism, Wiley-Blackwell 2013, Vol. 65, (Special issue, Supplement 10) : S589-S589, Meeting Abstract: 1393

Brink, Mikael; Bokarewa, Maria; Erlandsson, Malin; et al.

Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis

Arthritis and Rheumatism, Wiley-Blackwell 2013, Vol. 65, (4) : 899-910

Brink, Mikael; Hansson, Monika; Mathsson, Linda; et al.

B-Regulatory-, CD19(+)CD20(+) CD24(high)CD38(high) -Cells Are Functionally Impaired In Patients With Rheumatoid Arthritis and Healthy First Degree Relatives Compared With Controls

Arthritis and Rheumatism, Wiley-Blackwell 2013, Vol. 65, (Special issue, Supplement 10) : S393-S394, Meeting Abstract: 917

Brink, Mikael; Lejon, Kristina; Ärlestig, Lisbeth; et al.

The type I IFN signature as a biomarker of preclinical rheumatoid arthritis

Annals of the Rheumatic Diseases, London: BMJ Publishing Group 2013, Vol. 72, (5) : 776-780

Luebbers, Joyce; Brink, Mikael; de Stadt, Lotte A. van; et al.

Clusters of single nucleotide polymorphisms within the HLA-DRB1 gene in relation to antibodies against citrullinated peptides in individuals prior to the development of rheumatoid arthritis

Annals of the Rheumatic Diseases, Vol. 72, (Suppl. 3) : 112-113

Rantapää-Dahlqvist, Solbritt; Ärlestig, Lisbeth; Brink, Mikael; et al.

Antibodies against native collagen and citrullinated proteins precede the development of rheumatoid arthritis with a consecutive pattern

Annals of the Rheumatic Diseases, Vol. 71 : A22-A22

Brink, Mikael; Ronnelid, Johan; Hansson, Monika; et al.

Gene signatures to prediction rheumatoid arthritis development

Annals of the Rheumatic Diseases, Vol. 71 : A24-A24

Lubbers, Joyce; Brink, Mikael; van de Stadt, Lotte A.; et al.

Type 1 Interferon Signature Predicts Development of Rheumatoid Arthritis.

Arthritis and Rheumatism, Malden: Wiley-Blackwell 2011, Vol. 63, (10) : S848-S848

Lubbers, Joyce; Brink, Mikael; van de Stadt, Lotte A.; et al.

B-regulatory cells are functionally impaired in patients with rheumatoid arthritis and in their first degree relatives

Brink, Mikael; Ärlestig, Lisbeth; Rantapää-Dahlqvist, Solbritt; et al.

Inflammatory markers in serum and adipose tissue in relation to markers of sub-clinical atherosclerosis in rheumatoid arthritis patients

Ljung, Lotta; Bergholm, Robert; Brink, Mikael; et al.

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