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Nicklas Strömberg


Senior dental officer

Deciphering host receptor configurations for oral bacteria bacteria into diagnostics and therapeutics in precision dentistry.

Works at

Professor, combined with clinical employment at Department of Odontology Section: School of Dentistry, Cariology
1D, våning 5, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

Nicklas Strömberg and his group are studying why some but not others suffer from chronic infectious diseases such as caries and how dental care should be tailored based on needs.

Bacterial adhesion at the host interface and bacteria-bacteria interface has been pioneered in the human mouth. Salivary proline-rich protein (PRP) receptor epitope configurations drive colonization of oral commensal bacteria on teeth, while bacterial polysaccharide GalNAc configurations drive the pioneer oral biofilm communities. Nicklas Strömberg runs a research group that translates the understanding of how host receptors specify susceptibility and resistance and co-operate with microbial virulence in dental caries (ab below) and how this knowledge can be used in prediction (c, below) and pharmaceutical treatment of the disease by blocking the dual bacterial adhesion and patter recognition event.

EBioMedicine, Elsevier 2024, Vol. 101
Sheng, Nongfei; Mårell, Lena; Tumkur Sitaram, Raviprakash; et al.
European Journal of Orthodontics, Oxford University Press 2023, Vol. 45, (5) : 477-484
Enerbäck, Hanna; Lövgren, Mai Lin; Strömberg, Nicklas; et al.
iScience, Cell Press 2022, Vol. 25, (5)
Alharbi, Adel F.; Sheng, Nongfei; Nicol, Katie; et al.
BMJ Open, BMJ Publishing Group Ltd 2018, Vol. 8, (10)
Barman, Malin; Murray, Fiona; Bernardi, Angelina I.; et al.
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
EBioMedicine, Vol. 24 : 205-215
Esberg, Anders; Sheng, Nongfei; Mårell, Lena; et al.
EBioMedicine, Vol. 26 : 38-46
Strömberg, Nicklas; Esberg, Anders; Sheng, Nongfei; et al.
Infection and Immunity, Washington: American Society Microbiology 2012, Vol. 80, (11) : 3869-3879
Esberg, Anders; Löfgren-Burström, Anna; Öhman, Ulla; et al.
PLOS ONE, Vol. 7, (10) : e48364-
Persson, Karina; Esberg, Anders; Claesson, Rolf; et al.
Molecular Microbiology, Vol. 81, (4) : 1034-1049
Maddocks, Sarah E.; Wright, Christopher J.; Nobbs, Angela H.; et al.
Journal of Biological Chemistry, Vol. 284, (28) : 18614-23
Loimaranta, Vuokko; Hytönen, Jukka; Pulliainen, Arto T; et al.
BMC Oral Health, BioMed Central 2009, Vol. 9, (28)
Nordlund, Åke; Johansson, Ingegerd; Källestål, Carina; et al.
Glycoconjugate Journal, Vol. 24, (2-3) : 131-142
Eriksson, Christer; Frängsmyr, Lars; Danielsson Niemi, Liza; et al.
BMC Infectious Diseases, Vol. 11, (7) : 57-
Jonasson, Anette; Eriksson, C; Jenkinson, HF; et al.
Infection and Immunity, Washington: American society for microbiology 2006, Vol. 74, (11) : 6293-6299
Drobni, Mirva; Li, Tong; Krüger, Karina; et al.
Journal of Biological Chemistry, Vol. 281, (22) : 15164-15171
Drobni, Mirva; Olsson, Ing-Marie; Eriksson, Christer; et al.
International Congress Series 1289, Elsevier B.V. 2006 : 275-278
Jakubovics, N.S.; Brittan , J.L.; Kerrigan, S.; et al.
Journal of Nutrition, Vol. 135, (10) : 2445-2448
Hakkarainen, J; Toivanen, M; Leinonen, A; et al.
Infection and Immunity, Vol. 73, (10) : 6629-6638
Jakubovics, NS; Kerrigan, SW; Nobbs, AH; et al.
Molecular Microbiology, Vol. 55, (5) : 1591-1605
Jakubovics, NS; Strömberg, Nicklas; van Dolleweerd, CJ; et al.
Infection and Immunity, Vol. 73, (4) : 2245-2252
Loimaranta, V; Jakubovics, NS; Hytönen, J; et al.
Journal of Dental Research, Vol. 80, (11) : 2005-10
Stenudd, C; Nordlund, Åke; Ryberg, M; et al.
Oral Microbiology and Immunology, Vol. 15, (2) : 112-118
Johansson, Ingegerd; Bratt, P; Hay, DI; et al.
FEBS Letters, Vol. 475, (2) : 131-4
Jonsson, AP; Griffiths, WJ; Bratt, P; et al.
Journal of Biological Chemistry, Vol. 275, (51) : 39860-6
Prakobphol, A; Xu, F; Hoang, VM; et al.
Advances in Experimental Medicine and Biology, Vol. 408 : 9-24
Strömberg, Nicklas; Ahlfors, S; Borén, Thomas; et al.
Bugaytsova, Jeanna; Chernov, Yevgen A; Gideonsson, Pär; et al.

Research groups

Head of research
Nicklas Strömberg Lab