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Staff photo Oliver Billker

Oliver Billker

My research is about genome scale approaches to understand the biology of malaria parasites and how they interact with the mosquitoes that transmit them.

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Works at

Affiliation
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS) Role: Director
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

Malaria is caused by single-celled parasites that replicate inside red blood cells, and that naturally can only be transmitted by mosquitoes. We want to reveal the hidden and fascinating biology of these important organisms, so that it can be exploited by new drugs and vaccines.
 
Preconceived ideas can get in the way of new discoveries. We have therefore developed molecular tools to interrogate the functions of thousands of parasite genes simultaneously and in an unbiased manner. Now we can conduct genome-scale genetic screens in Plasmodium berghei, a species of parasite that only infects rodents and that we can study safely and easily at all stages of its life cycle. We transfer concepts for the effective discovery of gene functions from model organisms like yeast, to malaria parasites. This will help unlock important areas of parasite cell biology, from the regulation of development to parasite-host-mosquito interactions. Our discoveries have in many instances helped the research into new drugs and vaccines.

2020
Nature Communications, Nature Publishing Group 2020, Vol. 11, (1)
Adderley, Jack D.; von Freyend, Simona John; Jackson, Sarah A.; et al.
2020
Science Advances, American Association for the Advancement of Science 2020, Vol. 6, (6)
Akkaya, Munir; Bansal, Abhisheka; Sheehan, Patrick W.; et al.
2020
Wellcome open research, Wellcome open research 2020, Vol. 5
Marr, Edward J; Milne, Rachel M; Anar, Burcu; et al.
2020
Stem cell reports, Elsevier 2020, Vol. 14, (6) : 1123-1134
Tripathi, Jaishree; Segeritz, Charis-Patricia; Griffiths, Gareth; et al.
2019
Cell reports, Elsevier 2019, Vol. 28, (6) : 1635-1647
Hillier, Charles; Pardo, Mercedes; Yu, Lu; et al.
2019
Science, American Association for the Advancement of Science 2019, Vol. 365, (6455)
Howick, Virginia M.; Russell, Andrew J. C.; Andrews, Tallulah; et al.
2019
Cell, Elsevier 2019, Vol. 179, (5) : 1112-1128.e1-e15
Stanway, Rebecca R.; Bushell, Ellen; Chiappino-Pepe, Anush; et al.
2018
Cell Host and Microbe, Elsevier 2018, Vol. 24, (6) : 754-755
Billker, Oliver
2018
Genome Research, Cold Spring Harbor Laboratory Press (CSHL) 2018, Vol. 28, (4) : 547-560
Böhme, Ulrike; Otto, Thomas D.; Cotton, James A.; et al.
2018
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2018, Vol. 115, (17) : 4477-4482
Dundas, Kirsten; Shears, Melanie J.; Sun, Yi; et al.
2018
Nature Communications, Nature Publishing Group 2018, Vol. 9
Fang, Hanwei; Gomes, Ana Rita; Klages, Natacha; et al.
2018
Nature Microbiology, Nature Publishing Group 2018, Vol. 3, (11) : 1206-1213
Kent, Robyn S; Modrzynska, Katarzyna K; Cameron, Rachael; et al.
2018
Journal of Proteomics, Vol. 180 : 61-69
Moussa, Ehab; Huang, Honglei; Ahras, Malika; et al.
2018
eLIFE, eLife Sciences Publications, Ltd 2018, Vol. 7
Reid, Adam J.; Talman, Arthur M.; Bennett, Hayley M.; et al.
2017
eLIFE, eLife Sciences Publications 2017, Vol. 6
Billker, Oliver
2017
Nature Microbiology, Macmillan Publishers Ltd. 2017, Vol. 2, (4)
Brugat, Thibaut; Reid, Adam James; Lin, Jingwen; et al.
2017
Cell, Cell Press 2017, Vol. 170, (2) : 260-272.e1-e4
Bushell, Ellen; Gomes, Ana Rita; Sanderson, Theo; et al.
2017
Cell reports, Elsevier 2017, Vol. 21, (7) : 2017-2029
Invergo, Brandon M.; Brochet, Mathieu; Yu, Lu; et al.
2017
Science immunology, American Association for the Advancement of Science (AAAS) 2017, Vol. 2, (9)
Lönnberg, Tapio; Svensson, Valentine; James, Kylie R.; et al.
2017
Nature, Macmillan Publishers Ltd. 2017, Vol. 547, (7662) : 213-216
Mancio-Silva, Liliana; Slavic, Ksenija; Grilo Ruivo, Margarida T.; et al.
2017
Cell Host and Microbe, Cell Press 2017, Vol. 21, (1) : 11-22
Modrzynska, Katarzyna; Pfander, Claudia; Chappell, Lia; et al.
2016
Journal of Infectious Diseases, Oxford University Press 2016, Vol. 214, (12) : 1840-1849
Alkaitis, Matthew S.; Wang, Honghui; Ikeda, Allison K.; et al.
2016
Molecular Microbiology, John Wiley & Sons 2016, Vol. 100, (3) : 397-408
Brochet, Mathieu; Billker, Oliver
2016
Molecular Microbiology, John Wiley & Sons 2016, Vol. 102, (2) : 349-363
Govindasamy, K; Jebiwott, S; Jaijyan, D K; et al.
2016
Cellular Microbiology, John Wiley & Sons 2016, Vol. 18, (11) : 1625-1641
Hopp, Christine S; Balaban, Amanda E; Bushell, Ellen S C; et al.
2016
PLoS ONE, Public Library of Science 2016, Vol. 11, (3)
McInroy, Gordon R; Beraldi, Dario; Raiber, Eun-Ang; et al.
2016
Genome Biology, BioMed Central 2016, Vol. 17
Proserpio, Valentina; Piccolo, Andrea; Haim-Vilmovsky, Liora; et al.
2016
PLoS ONE, Public Library of Science 2016, Vol. 11, (6)
Yiangou, Loukia; Montandon, Ruddy; Modrzynska, Katarzyna; et al.
2015
Cell Host and Microbe, Elsevier 2015, Vol. 18, (1) : 9-10
Billker, Oliver; Rayner, Julian C.
2015
PLoS Pathogens, Public Library of Science 2015, Vol. 11, (9)
Chertow, Jessica H; Alkaitis, Matthew S; Nardone, Glenn; et al.
2015
Cell Host and Microbe, Cell Press 2015, Vol. 17, (3) : 404-413
Gomes, Ana Rita; Bushell, Ellen; Schwach, Frank; et al.
2015
Nucleic Acids Research, Oxford University Press 2015, Vol. 43, (Database issue) : D1176-D1182
Schwach, Frank; Bushell, Ellen; Gomes, Ana Rita; et al.
2015
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Yeung, A T Y; Hale, C; Xia, J; et al.
2014
Infection and Immunity, American Society for Microbiology 2014, Vol. 82, (3) : 1277-1286
Bauza, Karolis; Malinauskas, Tomas; Pfander, Claudia; et al.
2014
PLoS biology, Public Library of Science 2014, Vol. 12, (3)
Brochet, Mathieu; Collins, Mark O.; Smith, Terry K.; et al.
2014
PLoS Pathogens, PLOS 2014, Vol. 10, (7)
Oppenheim, Rebecca D.; Creek, Darren J.; Macrae, James I.; et al.
2014
BMC Biology, BioMed Central 2014, Vol. 12
Otto, Thomas D.; Böhme, Ulrike; Jackson, Andrew P.; et al.
2014
Nature, Macmillan Publishers Ltd. 2014, Vol. 507, (7491) : 253-257
Sinha, Abhinav; Hughes, Katie R.; Modrzynska, Katarzyna K; et al.
2013
PLoS ONE, Public Library of Science 2013, Vol. 8, (11) : e80723-e80723
Everitt, Aaron R; Clare, Simon; McDonald, Jacqueline U; et al.
2013
Traffic: the International Journal of Intracellular Transport, John Wiley & Sons 2013, Vol. 14, (8) : 895-911
Frénal, Karine; Tay, Chwen L.; Mueller, Christina; et al.
2013
Genes & Development, Cold Spring Harbor Laboratory Press (CSHL) 2013, Vol. 27, (10) : 1198-1215
Ning, Jue; Otto, Thomas D.; Pfander, Claudia; et al.
2013
Malaria: Methods and protocols, Humana Press 2013 : 127-138
Pfander, Claudia; Anar, Burcu; Brochet, Mathieu; et al.
2013
PLoS Pathogens, Public Library of Science 2013, Vol. 9, (12)
Suarez, Catherine; Volkmann, Katrin; Gomes, Ana Rita; et al.
2012
Journal of Clinical Investigation, American Society for Clinical Investigation 2012, Vol. 122, (6) : 2301-2305
Ojo, Kayode K; Pfander, Claudia; Mueller, Natascha R; et al.
2012
Cell Host and Microbe, Elsevier 2012, Vol. 12, (6) : 824-834
Pino, Paco; Sebastian, Sarah; Kim, Eunbin Arin; et al.
2012
Cell Host and Microbe, Elsevier 2012, Vol. 12, (1) : 9-19
Sebastian, Sarah; Brochet, Mathieu; Collins, Mark O.; et al.
2012
PLoS ONE, Public Library of Science 2012, Vol. 7, (7)
Volkmann, Katrin; Pfander, Claudia; Burstroem, Charlotte; et al.
2011
Nature Methods, Vol. 8, (12) : 1078-1082
Pfander, Claudia; Anar, Burcu; Schwach, Frank; et al.
2011
Experimental parasitology, Vol. 129, (1) : 75-80
Raabe, Andreas; Berry, Laurence; Sollelis, Lauriane; et al.
2011
Journal of Immunology, Vol. 186, (12) : 6657-6660
Ramos, Theresa N; Darley, Meghan M; Hu, Xianzhen; et al.

Research groups

Research Leader
Oliver Billker