Sa Chen

Contact

sa.chen@umu.se

Works as

Staff scientist at Department of Medical Biosciences

By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå

The p53 mRNA exhibits riboswitch-like features under DNA damage conditions

iScience, Elsevier 2025, Vol. 28, (10)

Chen, Sa; Wang, Lixiao; Malbert-Colas, Laurence; et al.

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

British Journal of Cancer, Springer Nature 2025, Vol. 133 : 970-975

Sajwan, Rhythm; Wang, Lixiao; Casar-Borota, Olivera; et al.

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Cell Death and Differentiation, Springer Nature 2023, Vol. 30 : 1072-1081

Fusée, Leila; Salomao, Norman; Ponnuswamy, Anand; et al.

DNA and RNA Binding Proteins: From Motifs to Roles in Cancer

International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (16)

Bonczek, Ondrej; Wang, Lixiao; Gnanasundram, Sivakumar Vadivel; et al.

FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer

Molecular Oncology

Flodbring Larsson, Per; Karlsson, Richard; Sarwar, Martuza; et al.

Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling

Cell Death and Disease, Springer Nature 2022, Vol. 13, (12)

Toh, Eric; Baryalai, Palwasha; Nadeem, Aftab; et al.

PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer

Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10

Wang, Tianyan; Sarwar, Martuza; Whitchurch, Jonathan B.; et al.

The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA

Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (17) : 10110-10122

Zheng, Alice J L; Thermou, Aikaterini; Daskalogianni, Chrysoula; et al.

P53 mRNA metabolism links with the DNA damage response

Genes, MDPI 2021, Vol. 12, (9)

Gnanasundram, Sivakumar Vadivel; Bonczek, Ondrej; Wang, Lixiao; et al.

MDM2's dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities

Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (12) : 6775-6787

Gnanasundram, Sivakumar Vadivel; Malbert-Colas, Laurence; Chen, Sa; et al.

Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase

Cancers, MDPI 2020, Vol. 12, (9)

Karlsson, Richard; Larsson, Per; Miftakhova, Regina R.; et al.

The p53 mRNA: an integral part of the cellular stress response

Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (7) : 3257-3271

Haronikova, Lucia; Olivares-Illana, Vanesa; Wang, Lixiao; et al.

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Biochemical Journal, PORTLAND PRESS LTD 2019, Vol. 476 : 3401-3411

Uhrik, Lukas; Wang, Lixiao; Haronikova, Lucia; et al.

Expression and function of Suppressor of zeste 12 in Drosophila melanogaster

Umeå University: 2009

Chen, Sa

Regulation of the Drosophila engrailed gene by Polycomb repressor complex 2

Mechanisms of Development, Amsterdam: Elsevier 2009, Vol. 126, (5-6) : 443-448

Chen, Sa; Rasmuson-Lestander, Åsa

In vivo analysis of Suppressor of zeste 12´s different isoforms

Chen, Sa; Larsson, Anna L.; Tegeling, Erik; et al.

The role of Suppressor of zeste 12 in cell cycle regulation

Chen, Sa; Rasmuson-Lestander, Åsa

Investigation of the two isoforms of SU(Z)12 shows difference in expressionand interaction in vitro with the core components of PRC2

Larsson, Anna; Tegeling, Erik; Chen, Sa; et al.

View publications in DiVA

Research groups

Group member

Robin Fåhraeus Lab

Research projects

5 December 2007 until 31 December 2010

Gene regulation in Drosophila