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Staff photo Sjoerd Wanrooij

Sjoerd Wanrooij

Molecular mechanism of DNA repair and replication in human mitochondria

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Location
KB. A6, Campus, Umeå Umeå universitet, 901 87 Umeå

Human mitochondrial DNA (mtDNA) encodes for genes that are essential for proper energy production. Loss of mtDNA function results in a broad range of genetic human disorders, and it is increasingly recognized as a significant factor in common disorders such as neurodegeneration. Our group investigates detailed molecular mechanisms of mitochondrial DNA replication and repair in order to better understand the underlying causes of such disease states.

Biochimica et Biophysica Acta. Molecular Cell Research, Elsevier 2022, Vol. 1869, (1)
Inatomi, Teppei; Matsuda, Shigeru; Ishiuchi, Takashi; et al.
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (14) : 8199-8213
Calvo, Patricia A; Martínez-Jiménez, María I; Díaz, Marcos; et al.
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (11)
Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; et al.
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (4) : 2179-2191
Kasho, Kazutoshi; Stojkovic, Gorazd; Velázquez-Ruiz, Cristina; et al.
The Human Mitochondrial Genome: From Basic Biology to Disease, Academic Press 2020 : 3-33
Doimo, Mara; Pfeiffer, Annika; Wanrooij, Paulina H.; et al.
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
Angewandte Chemie International Edition, Vol. 58, (5) : 1417-1421
Moodie, Lindon W. K.; Hubert, Madlen; Zhou, Xin; et al.
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (18) : 9471-9483
Al-Behadili, Ali; Uhler, Jay P.; Berglund, Anna-Karin; et al.
PLoS Genetics, Public library science 2018, Vol. 14, (3)
Forslund, Josefin M. E.; Pfeiffer, Annika; Stojkovič, Gorazd; et al.
Bioessays, Wiley-Blackwell 2018, Vol. 40, (9)
Pohjoismäki, Jaakko L. O.; Forslund, Josefin; Goffart, Steffi; et al.
PLOS ONE, PUBLIC LIBRARY SCIENCE 2017, Vol. 12, (9)
Boldinova, Elizaveta O.; Stojkovic, Gorazd; Khairullin, Rafil; et al.
International Journal of Molecular Sciences, MDPI AG 2017, Vol. 18, (7)
Boldinova, Elizaveta O.; Wanrooij, Paulina H.; Shilkin, Evgeniy S.; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (43) : 11398-11403
Torregrosa-Muñumer, Rubén; Forslund, Josefin M. E.; Goffart, Steffi; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Scientific Reports, Vol. 6
Stojkovic, Gorazd; Makarova, Alena V.; Wanrooij, Paulina H.; et al.
Biochimica et Biophysica Acta. Molecular Cell Research, Vol. 1853, (10) : 2580-2591
Al-Furoukh, Natalie; Ianni, Alessandro; Nolte, Hendrik; et al.
PLOS Genetics, Vol. 10, (12) : e1004832-
Miralles Fusté, Javier; Shi, Yonghong; Wanrooij, Sjoerd; et al.

Research groups

Head of research
Sjoerd Wanrooij