Stefan Björklund

Professor at Department of Medical Biochemistry and Biophysics

stefan.bjorklund@umu.se

+46 70 216 28 90

KB. A6, Campus, Umeå Umeå universitet, 901 87 Umeå

The mediator complex and its function in transcriptional regulation at the molecular level

Latest publications

2018

The MED7 subunit paralogs of Mediator function redundantly in development of etiolated seedlings in Arabidopsis

The Plant Journal, John Wiley & Sons 2018, Vol. 96, (3) : 578-594

Kumar, Koppolu Raja Rajesh; Blomberg, Jeanette; Björklund, Stefan

2017

Functional metabolomics as a tool to analyze Mediator function and structure in plants

PLoS ONE, Public Library Science 2017, Vol. 12, (6)

Davoine, Celine; Abreu, Ilka N.; Khajeh, Khalil; et al.

2017

Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly

Nucleic Acids Research, Oxford University Press 2017, Vol. 45, (15) : 8806-8821

Chereji, Razvan V.; Bharatula, Vasudha; Elfving, Nils; et al.

2017

MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana

PLoS ONE, PUBLIC LIBRARY SCIENCE 2017, Vol. 12, (4)

Fallath, Thorya; Kidd, Brendan N.; Stiller, Jiri; et al.

2016

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence

Protoplasma, Vol. 253, (3) : 957-963

Shaikhali, Jehad; Davoine, Céline; Björklund, Stefan; et al.

2015

Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein

Biochemical Journal, Vol. 468, (3) : 385-400

Shaikhali, Jehad; Davoine, Celine; Brännström, Kristoffer; et al.

2015

The Msn2 mediated stress response: Survival based on "hedging your bet" and a dynamic interplay of transcription factor binding and nucleosome occupancy

Yeast, Wiley-Blackwell 2015, Vol. 32, (Suppl. 1) : S221-S222

Broach, James R; Bharatula, Vasudha; Chereji, Razvan; et al.

2014

A dynamic interplay of nucleosome and Msn2 binding regulates kinetics of gene activation and repression following stress

Nucleic Acids Research, Vol. 42, (9) : 5468-5482

Elfving, Nils; Chereji, Razvan V.; Bharatula, Vasudha; et al.

2014

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors

PLoS ONE, Vol. 9, (5) : e98575-

Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.

2013

Functional Studies of the Yeast Med5, Med15 and Med16 Mediator Tail Subunits

PLoS ONE, Vol. 8, (8) : e73137-

Larsson, Miriam; Uvell, Hanna; Sandström, Jenny; et al.

2012

Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes

Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950

Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.

2011

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, (20) : 8245-8250

Elfving, Nils; Davoine, Céline; Benlloch, Reyes; et al.

2009

Med8, Med18, and Med20 subunits of the Mediator head domain are interdependent upon each other for folding and complex formation

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, (49) : 20728-20733

Shaikhibrahim, Zaki; Rahaman, Hamidur; Wittung-Stafshede, Pernilla; et al.

2007

Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit

Molecular Cell, Vol. 26, (5) : 717-729

Bäckström, Stefan; Elfving, Nils; Nilsson, Robert; et al.

2006

Functional and physical interactions within the middle domain of the yeast mediator

Molecular Genetics and Genomics, Vol. 276, (2) : 197-210

Hallberg, Magnus; Hu, Guo-Zhen; Tronnersjö, Susanna; et al.

2005

The yeast Mediator complex and its regulation.

Trends in Biochemical Sciences, Vol. 30, (5) : 240-4

Björklund, Stefan; Gustafsson, Claes M

2004

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Molecular Cell, Vol. 14, (5) : 553-7

Bourbon, Henri-Marc; Aguilera, Andres; Ansari, Aseem Z; et al.

2004

S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region.

Journal of biological chemistry, Vol. 279, (11) : 10796-807

Chabes, Anna Lena; Björklund, Stefan; Thelander, Lars

2004

Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, (10) : 3370-3375

Hallberg, Magnus; Polozkov, Gennady; Hu, Guo-Zhen; et al.

2004

The mediator complex.

Advances in Protein Chemistry, Vol. 67 : 43-65

Björklund, Stefan; Gustafsson, Claes M

2003

Functional interactions within yeast mediator and evidence of differential subunit modifications

Journal of Biological Chemistry, Vol. 278, (6) : 3831-3839

Balciunas, Darius; Hallberg, Magnus; Björklund, Stefan; et al.

2003

Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription

European Journal of Biochemistry, Blackwell Publishing 2003, Vol. 270, (8) : 1791-1801

Kotova, Irina; Chabes, Anna Lena; Lobov, Sergei; et al.

2001

A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH, and recombinant TBP, TFIIB, TFIIE and TFIIF.

European Journal of Biochemistry, Vol. 268, (16) : 4527-4536

Kotova, Irina; Chabes, Anna Lena; Segerman, Bo; et al.

1996

Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.

Journal of Biological Chemistry, Vol. 271, (39) : 23698-704

Filatov, D; Björklund, Stefan; Johansson, Erik; et al.

1996

Mediator of transcriptional regulation.

TIBS -Trends in Biochemical Sciences. Regular ed., Vol. 21, (9) : 335-7

Björklund, Stefan; Kim, Y J

1996

Yeast RNA polymerase II holoenzyme.

Methods in Enzymology, Vol. 273 : 172-5

Li, Y; Bjorklund, Stefan; Kim, Y J; et al.

1995

Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, (18) : 8224-8

Poon, D; Bai, Y; Campbell, A M; et al.

1995

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, (24) : 10864-8

Li, Y; Bjorklund, Stefan; Jiang, Y W; et al.

1994

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

Cell, Vol. 77, (4) : 599-608

Kim, Y J; Björklund, Stefan; Li, Y; et al.

1994

Gene structure and regulation of the expression of the R1 and R2 subunits of mouse ribonucleotide reductase.

Advances in Experimental Medicine and Biology, Vol. 370 : 721-4

Johansson, Erik; Björklund, Stefan; Thelander, Lars

1993

Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase.

Proceedings of the National Academy of Science U S A, Vol. 90, (23) : 11322-6

Björklund, Stefan; Hjortsberg, K; Johansson, Erik; et al.

1992

An S-phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit

EMBO Journal, Vol. 11, (13) : 4953-4959

Björklund, Stefan; Skogman, E; Thelander, Lars

1990

S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

Biochemistry, Vol. 29, (23) : 5452-5458

Björklund, Stefan; Skog, Sven; Tribukait, Bernard; et al.

Functional and physical interactions of the Mediator subunit Med21/Srb7

Hallberg, Magnus; Hu, Guo-Zhen; Balciunas, Darius; et al.

Mechanisms of transcriptional activation of the AdML promoter by NF-Y.

Frontini, M; Kotova, Irina; Björklund, Stefan; et al.

Mediator exists in multiple forms and is predominantly associated to promoters with low nuclesome density

Elfving, Nils; Chereji, Razvan; Larsson, Miriam; et al.

Phosphorylation of Serine 208 in Med2 is important for proper expression of genes required for anaerobic growth and purine and glykogen metabolism

Hallberg, Magnus; Polozkov, Gennady; Deluen, Cécile; et al.

S phase-specific transcription of the mouse ribonucleotide reductase R2 gene is dependent on an upstream promoter activating region and a proximal repressive E2F binding site.

Chabes, Anna Lena; Björklund, Stefan; Thelander, Lars

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Research projects

23 April 2003 until 31 December 2014

The function of Mediator in transcriptional regulation

Research subject: Biological sciences, Chemical sciences, Molecular medicine

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Stefan Björklund

Latest publications

Research projects