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Umeå University
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Thomas Grundström

Our research group tries to understand the control of mutagenesis and class switch recombination of antibody genes.

Contact

E-mail
thomas.grundstrom@umu.se
Phone
+46 90 785 25 31

Works at

Affiliation
Affiliated as professor emeritus at Department of Molecular Biology Section: Research group Thomas Grundström
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
The transcription factor E2A can bind to and cleave single-stranded immunoglobulin heavy chain locus DNA
Molecular Immunology, Elsevier 2023, Vol. 153 : 51-59
Grundström, Christine; Grundström, Thomas
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
Molecular Oncology
Flodbring Larsson, Per; Karlsson, Richard; Sarwar, Martuza; et al.
PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Wang, Tianyan; Sarwar, Martuza; Whitchurch, Jonathan B.; et al.
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer
Molecular Oncology, John Wiley & Sons 2021, Vol. 15, (4) : 968-986
Semenas, Julius; Wang, Tianyan; Khaja, Azharuddin Sajid Syed; et al.
Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase
Cancers, MDPI 2020, Vol. 12, (9)
Karlsson, Richard; Larsson, Per; Miftakhova, Regina R.; et al.
ETS1 and PAX5 transcription factors recruit AID to Igh DNA
European Journal of Immunology, Wiley-VCH Verlagsgesellschaft 2018, Vol. 48, (10) : 1687-1697
Grundström, Christine; Kumar, Anjani; Priya, Anshu; et al.
Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination
Journal of Immunology, American Association of Immunologists 2018, Vol. 200, (12) : 4146-4156
Kumar, Anjani; Priya, Anshu; Ahmed, Tanzeel; et al.
Regulation of diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Spandidos 2016, Vol. 38 : S43-S43
Grundström, Thomas; Hauser, Jannek; Grundström, Christine; et al.
Regulated localization of an AID complex with E2A, PAX5 and IRF4 at the Igh locus
Molecular Immunology, Vol. 80 : 78-90
Hauser, Jannek; Grundström, Christine; Kumar, Ramesh; et al.
Mechanisms controlling diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Vol. 36 : S43-S43
Grundström, Thomas; Hauser, Jannek; Grundström, Christine; et al.
Signal regulated localisation of a mutagenic protein complex at the Igh locus
The FEBS Journal, Wiley-Blackwell 2015, Vol. 282 : 13-13
Hauser, Jannek; Grundström, Christine; Kumar, Ramesh; et al.
Allelic Exclusion of IgH through Inhibition of E2A in a VDJ Recombination Complex
Journal of Immunology, Bethesda: American Association of Immunologists 2014, Vol. 192, (5) : 2460-2470
Hauser, Jannek; Grundström, Christine; Grundström, Thomas
Regulation of diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Spandidos publishing 2014, Vol. 34 : S50-S50
Hauser, Jannek; Kumar, Ramesh; Wallenius, Anders; et al.
Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification
Molecular Immunology, Vol. 60, (1) : 23-31
Wallenius, Anders; Hauser, Jannek; Aas, Per Arne; et al.
Broad feedback inhibition of pre-B-cell receptor signaling components
Molecular Immunology, Elsevier 2013, Vol. 54, (3-4) : 247-253
Hauser, Jannek; Verma-Gaur, Jiyoti; Grundström, Thomas
Mechanisms controlling diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Vol. 32 : S45-S45
Hauser, Jannek; Verma-Gaur, Jiyoti; Wallenius, Anders; et al.
Mechanisms regulating diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Athen: Spandidos publications 2012, Vol. 30, (Suppl 1) : S42-S42
Hauser, Jannek; Verma-Gaur, Jiyoti; Wallenius, Anders; et al.
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A
Journal of Immunology, Vol. 188, (12) : 6175-6183
Verma-Gaur, Jiyoti; Hauser, Jannek; Grundström, Thomas
Regulatory mechanisms controlling diversification and affinity maturation of antibodies
International Journal of Molecular Medicine, Vol. 28 Suppl. 1
Hauser, Jannek; Verma-Gaur, Jiyoti; Wallenius, Anders; et al.
CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB
Molecular Immunology, Oxford: 2011, Vol. 48, (12-13) : 1448-1460
Oruganti, Sreenivasa Rao; Edin, Sofia; Grundström, Christine; et al.
CaMKII targets Bc110 in T-cell receptor induced activation of NF-κB
Molecular Immunology, Elsevier 2011, Vol. 48, (12-13) : 1448-1460
Oruganti, Sreenivasa Rao; Edin, Sofia; Grundström, Christine; et al.
Interaction of calmodulin with Bcl10 modulates NF-kappaB activation.
Molecular Immunology, Elsevier 2010, Vol. 47, (11-12) : 2057-2064
Edin, Sofia; Oruganti, Sreenivasa Rao; Grundström, Christine; et al.
Calmodulin inhibition of E2A stops expression of surrogate light chains of the pre-B-cell receptor and CD19
Molecular Immunology, Vol. 47, (5) : 1031-1038
Hauser, Jannek; Wallenius, Anders; Sveshnikova, Natalia; et al.
Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A
Journal of Immunology, Vol. 183, (2) : 1179-1187
Hauser, Jannek; Verma-Gaur, Jiyoti; Wallenius, Anders; et al.
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, (4) : 1169-1174
Lai, Dazhi; Wan, Mimi; Wu, Jie; et al.
Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors
Molecular Biology of the Cell, Vol. 19, (6) : 2509-2519
Hauser, Jannek; Saarikettu, Juha; Grundström, Thomas
B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins
Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, (4) : 1267-1272
Hauser, Jannek; Sveshnikova, Natalia; Wallenius, Anders; et al.
Identification of an N-terminal transactivation domain of Runx1 that separates molecular function from global differentiation function.
J Biol Chem, Vol. 281, (35) : 25659-69
Liu, Hebin; Carlsson, Leif; Grundström, Thomas
Backbone dynamics of a symmetric calmodulin dimer in complex with the calmodulin-binding domain of the basic-helix-loop-helix transcription factor SEF2-1/E2-2: a highly dynamic complex.
Biophys J, Vol. 89, (2) : 1214-26
Larsson, Göran; Schleucher, Jürgen; Onions, Jacqueline; et al.
AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.
Journal of Biological Chemistry, Vol. 279, (28) : 29398-29408
Liu, Hebin; Holm, Magnus; Xie, Xiao-Qi; et al.
Calcium/calmodulin inhibition of transcriptional activity of E-proteins by prevention of their binding to DNA.
Journal of Biological Chemistry, Vol. 279, (39) : 41004-41011
Saarikettu, Juha; Sveshnikova, Natalia; Grundström, Thomas
Regulation of c-Rel Nuclear Localization by Binding of Ca2+/Calmodulin
Molecular and Cellular Biology, American Society for Microbiology 2003, Vol. 23, (4) : 1418-1427
Antonsson, Åsa; Hughes, Kate; Edin, Sofia; et al.
The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.
J Mol Biol, Vol. 322, (2) : 259-72
Bäckström, Stefan; Wolf-Watz, Magnus; Grundström, Christine; et al.
Gene expression in transfected cells
Calcium-Binding Protein Protocols: Volume 2: Methods and Techniques, Totowa, NJ: Humana Press 2002 : 355-363
Hughes, Kate; Saarikettu, Juha; Grundström, Thomas
Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1
Molecular Biology of the Cell, Vol. 13, (12) : 4497-4507
Liu, Hebin; Grundström, Thomas
Crystallization and preliminary studies of the DNA-binding runt domain of AML1.
Acta Crystallogr D Biol Crystallogr, Vol. 57, (Pt 2) : 269-71
Bäckström, Stefan; Huang, Shenghua; Wolf-Watz, Magnus; et al.
Calmodulin-dependent Kinase II Mediates T Cell Receptor/CD3- and Phorbol Ester-induced Activation of IκB Kinase
Journal of Biological Chemistry, Vol. 276, (38) : 36008-36013
Hughes, Kate; Edin, Sofia; Antonsson, Åsa; et al.
PEBP2 and c-myb sites crucial for lambda5 core enhancer activity in pre-B cells.
European Journal of Immunology, Vol. 31, (11) : 3165-3174
Mårtensson, Annica; Xie, Xiao-Qi; Persson, Christine; et al.
Structure and backbone dynamics of Apo-CBFbeta in solution.
Biochemistry, Vol. 40, (38) : 11423-11432
Wolf-Watz, M; Grundström, Thomas; Härd, T
Chloride binding by the AML1/Runx1 transcription factor studied by NMR
FEBS Letters, Vol. 488, (1-2) : 81-4
Wolf-Watz, Magnus; Bäckström, Stefan; Grundström, Thomas; et al.
The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development
European Journal of Immunology, Wiley-VCH Verlagsgesellschaft 2000, Vol. 30, (10) : 2857-2863
Bergqvist, Ingela; Eriksson, Maria; Saarikettu, Juha; et al.
A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
Biochemistry, Vol. 39, (15) : 4366-4374
Onions, Jacqueline; Hermann, Stefan; Grundström, Thomas
AML and Ets proteins regulate the I alpha1 germ-line promoter.
European Journal of Immunology, Vol. 29, (2) : 488-498
Xie, Xiao-Qi; Pardali, Evangelia; Holm, Magnus; et al.
Calcium regulation of basic helix-loop-helix transcription factors
Cell Calcium, Elsevier 1998, Vol. 23, (2-3) : 135-142
Hermann, Stefan; Saarikettu, Juha; Onions, Jacqueline; et al.
Calmodulin dependence of NFκB activation
FEBS Letters, Elsevier 1998, Vol. 441, (1) : 132-136
Hughes, Kate; Antonsson, Åsa; Grundström, Thomas
Regulation of allelic exclusion of IgH by calmodulin inhibition of E2A
Hauser, Jannek; Grundström, Thomas
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A
Verma-Gaur, Jiyoti; Hauser, Jannek; Grundström, Thomas
View publications in DiVA

Research groups

Head of research
Thomas Grundström lab