PhD thesis 1982, Research Fellow (Sw. docent) and Senior Consultant 1991, Professor of Biomedicine (Örebro) 2001, Professor and Senior Consultant in Clinical Chemistry, Umeå University 2013.
Research profile
One-carbon metabolism
Genetic variation in genes of the one-carbon metabolism such as CHDH, COMT, CTH, MTHFR and in folate transporter genes such as FOLR1, RFC1, PCFT. Their importance for clinical phenotypes such as cognition, emotions, and blood biomarkers such as homocysteine, folate, cobalamin, etc.
Epigenetics
DNA methylation and its role in cell differentiation, for instance in embryonal malformations and cancer transformation.
Mitochondrial metabolism
Uncoupling proteins –genetic variation and functional roles. Choline metabolism and transport in the mitochondria.
Cardiovascular risk factors
Fibrinolysis and coagulation, platelet function, lipids, nutritional intake.
General Clinical Biochemistry
Development and evaluation of analytical methods, particularly in DNA methylation. Collecting and analyzing biobanks of biological samples from patients and control subjects. Cardiovascular risk factors (acquired and inherited). Risk factors for dementia. Familial defects in platelet aggregation. Hemoglobinopathies. Familial Mediterranean Fever. Pediatric Clinical Biochemistry and Epidemiology.