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Staff photo Ulf Ahlgren

Ulf Ahlgren

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MBC, vån 4, B-flygeln, Johan Bures Väg 12, B-425 Umeå universitet, 901 87 Umeå

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Ulf Ahlgren obtained a PhD in Medical Molecular biology at Umeå University (UmU) in 1999, focusing on transcriptional regulation of endocrine cell differentiation in the pancreas. After graduation, he worked a shorter period as head of the Umeå Transgenic Core Facility. He was awarded a post-doctoral fellowship from the Swedish Foundation for Internationalisation in Research and Higher Education (STINT), and he obtained post-doctoral training at the Medical Research Council, Human Genetics Unit in Edinburgh, UK.  His post-doctoral work focused on tissue interactions during development of the spleno-pancreatic region and he also contributed to the development of a novel imaging technology, optical projection tomography (OPT), which for the first time enabled mesoscopic imaging of mm-cm sized specimen with high molecular specificity and resolution.

In 2002, Ulf was recruited to the Umeå Centre for Molecular Medicine (UCMM) UmU on a tenure track position, and he also received an Assistant ­ Professorship position from the Swedish Research Council.  In 2006, he became became Associate Professor (Docent) in Medical Developmental Biology. At UCMM, Ulf’s lab has further increased the capacity of the OPT imaging technology to enable imaging of intact organs from rodent disease models. Facilitated by these advances, the lab has over the years presented novel information regarding aspects of pancreas biology ranging from normal pancreatic anatomy to e.g. disturbed proliferation, destruction, neogenesis, preservation and cellar re-programming of pancreatic cell-types. Based on such 3D data of the pancreas, he recently contributed the chapter on “the Pancreas” in the leading atlas of mouse anatomy.

Today, the lab runs two primary lines of research. The first line attempts to further utilise mesoscopic imaging techniques to provide the hitherto most detailed assessment of the relationship between the development of diabetes and (remaining) islet mass in the human pancreas. The group also has a strong interest in the potential of vibrational spectroscopy to perform biochemical analyses of the pancreatic islets in vivo. Since 2011 Ulf is working as a full time Professor of Molecular Medicine at UCMM, and since 2016 he has been appointed head-, and deputy head, respectively of UCMM.

 

Ulf research group has obtained funding from; the Swedish Research Council, the European Union, the Juvenile Diabetes Foundation (New York), the NovoNordisk foundation, the Kempe Foundations, the Diabetes Wellness Foundation, Barndiabetesfonden & Diabetesfonden.

 

Ask Ulf about: optical imaging techniques, pancreas anatomy, 3D modelling of biological data, diabetes and mouse models.

2018
Diabetologia, Springer 2018, Vol. 61, (4) : 896-905
Medina, Anya; Parween, Saba; Ullsten, Sara; et al.
2018
Journal of Endocrinological Investigation, Springer 2018, Vol. 41, (6) : 691-701
Grong, E.; Nord, Christoffer; Arbo, I. B.; et al.
2017
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Nord, Christoffer; Eriksson, Maria; Dicker, Andrea; et al.
2017
Scientific Reports, NATURE PUBLISHING GROUP 2017, Vol. 7
van Krieken, Pim P.; Dicker, Andrea; Eriksson, Maria; et al.
2017
Scientific Data, Vol. 4
Parween, Saba; Eriksson, Maria; Nord, Christoffer; et al.
2016
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Parween, Saba; Kostromina, Elena; Nord, Christoffer; et al.
2016
Surgical Endoscopy, Vol. 30, (2) : 532-542
Grong, Eivind; Kulseng, Bård; Arbo, Ingerid Brænne; et al.
2016
Scientific Reports, Vol. 6
Eter, Wael A.; Parween, Saba; Joosten, Lieke; et al.
2015
Disease Models and Mechanisms, Vol. 8, (12) : 1517-1529
Jones, Iwan; Hägglund, Anna-Carin; Törnqvist, Gunilla; et al.
2015
Scientific Reports, Vol. 5
Ilegems, E.; van Krieken, P. P.; Edlund, P. K.; et al.
2015
PLoS ONE, Vol. 10, (5)
Witek, Barbara; El Wakil, Abeer; Nord, Christoffer; et al.
2015
Kaufman's atlas of mouse development supplement: with coronal sections, Elsevier 2015 : 85-94
Hörnblad, Andreas; Nord, Christoffer; Parween, Saba; et al.
2014
Molecular Biology of the Cell, American Society for Cell Biology 2014, Vol. 25, (8) : 1384-1395
Nord, Hanna; Burguiere, Anne-Cecile; Muck, Joscha; et al.
2014
Nature Biotechnology, Vol. 32, (1) : 76-83
Baeyens, Luc; Lemper, Marie; Leuckx, Gunter; et al.
2013
TrAC. Trends in analytical chemistry, Vol. 44 : III-III
Ahlgren, Ulf
2013
Optics Express, Optical Society of America 2013, Vol. 21, (14) : 16584-16604
Cheddad, Abbas; Nord, Christoffer; Hörnblad, Andreas; et al.
2013
Journal of Visualized Experiments, Vol. 71
Eriksson, Anna U.; Svensson, Christoffer; Hörnblad, Andreas; et al.
2013
Cell Death and Disease, London: Nature Publishing Group 2013, Vol. 4 : e523-
Van de Casteele, M.; Leuckx, G.; Baeyens, L.; et al.
2013
Physical Biology, Institute of Physics Publishing (IOPP) 2013, Vol. 10, (3) : 036009-
Jo, Junghyo; Hörnblad, Andreas; Kilimnik, German; et al.
2012
Imaging in Medicine, Vol. 4, (1) : 5-7
Ahlgren, Ulf
2012
IEEE Transactions on Medical Imaging, Vol. 31, (1) : 1-15
Cheddad, Abbas; Svensson, Christoffer; Sharpe, James; et al.
2012
Islets, Landes bioscience 2012, Vol. 4, (1) : 10-19
Jo, Junghyo; Hara, Manami; Ahlgren, Ulf; et al.
2012
Diabetologia, Vol. 55, (12) : 3331-40
Pardo, F N; Altirriba, J; Pradas-Juni, M; et al.
2011
Islets, Austin: Landes Bioscience 2011, Vol. 3, (4) : 204-208
Hörnblad, Andreas; Cheddad, Abbas; Ahlgren, Ulf
2011
Developmental Biology, Academic Press 2011, Vol. 352, (2) : 267-277
Sand, Fredrik Wolfhagen; Hörnblad, Andreas; Johansson, Jenny K; et al.
2011
Type 1 diabetes: pathogenesis, genetics and immunotherapy
Ahlgren, Ulf; Kostromina, Elena
2011
PLoS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (6) : e21753-
Hörnblad, Andreas; Eriksson, Anna; Sock, Elisabeth; et al.
2010
Advances in Experimental Medicine and Biology, Springer Netherlands 2010, Vol. 654 : 39-57
Ahlgren, Ulf; Gotthardt, Martin
2010
Diabetes, Vol. 59, (7) : 1756-1764
Alanentalo, Tomas; Hörnblad, Andreas; Mayans, Sofia; et al.
2009
Differentiation, Vol. 77, (4) : 386-394
Lorén, Christina E; Schrader, John W; Ahlgren, Ulf; et al.
2009
Islets, Vol. 1, (2) : 163-164
Ahlgren, Ulf; Hörnblad, Andreas
2008
Journal of Biomedical Optics, Bellingham, WA: SPIE--the International Society for Optical Engineering 2008, Vol. 13, (5) : 054070-
Alanentalo, Tomas; Lorén, Christina E; Larefalk, Asa; et al.
2008
Diabetologia, Vol. 51, (12) : 2148-2154
Holmberg, Dan; Ahlgren, Ulf
2007
Nature Methods, Vol. 4, (1) : 31-33
Alanentalo, Tomas; Asayesh, Amir; Morrison, Harris; et al.
2006
Genes & Development, Vol. 20, (16) : 2208-2213
Asayesh, Amir; Sharpe, James; Watson, Robert P; et al.
2005
Developmental Dynamics, Vol. 232, (4) : 1105-1114
Asayesh, Amir; Alanentalo, Tomas; Khoo, Nelson K S; et al.
2005
Diabetes, Vol. 54, (1) : 125-32
Norlin, Stefan; Ahlgren, Ulf; Edlund, Helena
2004
Development, Vol. 131, (19) : 4665-75
Hecksher-Sørensen, Jacob; Watson, Robert P; Lettice, Laura A; et al.

Research groups

Head of project
Ulf Ahlgren