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Staff photo Urban Hellman

Urban Hellman

My research interest is the metabolism of hyaluronan in inflammation and tissue growth.

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Affiliation
Senior research engineer at Department of Public Health and Clinical Medicine Units: Section of Medicine
Location
Byggnad 6M, 3tr (M 31), Norrlands universitetssjukhus, rum 5030

2010 I defended my thesis on hyaluronan in cardiac hypertrophy. I am researching hereditary heart diseases, rheumatic diseases and metabolic diseases and supervising students at the lab. I also work at Norrland University Hospital at Heart Center and the Centre for Cardiovascular Genetics as a healthcare developer. 

My research interest is the significance of extracellular matrix in growth and inflammation in pathological and healthy tissue. The metabolism of the glycosaminoglycan hyaluronan and its involvement of energy metabolism and glucose have evolved into my research focus. Over the years, I have studied hyaluronan metabolism in hypertrophic cardiomyopathy, psoriasis arthritis, pancreatic cancer, ankylosing spondylitis, systemic lupus erythematosus, keloid, scleroderma, respiratory papilloma and developed new methods for analysis of hyaluronan.

Together with Göran Larsson, we are now developing a method to protect hyaluronan against degradation and inhibit the emergence of bioactive fragments, which are part of the inflammatory process.
During 2018, I worked at the department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, USA. We developed a method for concentration and sizing measurements of hyaluronan. At the Matrix Biology Institute, New Jersey, I studied how elevated concentration of hyaluronan around cultured cardiomyocytes affects their contractions negatively and thereby causes a potential arrhythmia risk.

I also help Andreas Josefsson, WCMM, with hyaluronan analysis in his project on prostate cancer and circulating tumor cells. Hyaluronan interaction with transthyretin in the heart of amyloidosis is another interest I have together with Intissar Anan, WCMM/Medicine, Malin Olsson at the division of Medicine and Anders Olofsson, Medical biochemistry and biophysics.

Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2021, Vol. 80, (Suppl 1) : 13-14
Forsblad-D'elia, H.; Hellman, Urban; Kumar, A.; et al.
Amyloid: Journal of Protein Folding Disorders
Olsson, Malin; Hellman, Urban; Wixner, Jonas; et al.
Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology (ASBMB) 2020, Vol. 295, (45) : 15418-15422
Hellman, Urban; Karlsson, Mats G.; Engström-Laurent, Anna; et al.
Arthritis & Rheumatology, John Wiley & Sons 2020, Vol. 72
Lejon, Kristina; Hellman, Urban; Do, Lan; et al.
Journal of Pathology, John Wiley & Sons 2019, Vol. 5, (2) : 130-141
Franklin, Oskar; Billing, Ola; Öhlund, Daniel; et al.
Scandinavian Journal of Rheumatology, Taylor & Francis Group 2019, Vol. 48, (4) : 284-293
Hellman, Urban; Engström-Laurent, Anna; Larsson, Anders; et al.
Scandinavian Journal of Clinical and Laboratory Investigation, Taylor & Francis 2019, Vol. 79, (6) : 372-376
Hellman, Urban; Lång, Kenneth; Ihse, Elisabet; et al.
Medicine (Baltimore, Md.), Wolters Kluwer 2019, Vol. 98, (15)
Hellman, Urban; Mörner, Stellan; Henein, Michael
Cells, MDPI 2019, Vol. 8, (2)
Lorén, Christina; Dahl, Christen P.; Do, Lan; et al.
Acta Oto-Laryngologica, Taylor & Francis 2018, Vol. 138, (11) : 1020-1027
Holm, Anna; Hellman, Urban; Laurent, Claude; et al.
Clinical and Experimental Rheumatology, CLINICAL & EXPER RHEUMATOLOGY 2018, Vol. 36, (4) : 716-716
Kumar, A.; Do, Lan; Hellman, Urban; et al.
Clinical and Experimental Rheumatology, Vol. 36, (4) : 716-716
Kumar, Anjani; Do, Lan; Hellman, Urban; et al.
Connective Tissue Research, Taylor & Francis 2016, Vol. 57, (5) : 337-346
Kerje, Susanne; Hellman, Urban; Do, Lan; et al.
Journal of Voice, Vol. 30, (3) : 255-262
Opheim, Leif Runar; Hellman, Urban; Engström-Laurent, Anna; et al.
PLOS ONE, Public Libray Science 2016, Vol. 11, (7)
Svennerholm, Kristina; Rodsand, Pouria; Hellman, Urban; et al.
European Journal of Medical Genetics, Vol. 58, (4) : 211-215
Hellman, Urban; Lundgren, Hans-Erik; Westermark, Per; et al.
International Journal of Cardiology Heart and Vasculature, Elsevier 2015, Vol. 8 : 62-67
Svennerholm, Kristina; Rodsand, Pouria; Hellman, Urban; et al.
International Cardiovascular Forum Journal, Barcaray International Publishing 2014, Vol. 1, (5) : 226-229
Hellman, Urban
Journal of Extracellular Vesicles, Co-action publishing 2013, Vol. 2
Gennebäck, Nina; Hellman, Urban; Malm, Linus; et al.
Cardiogenetics, Vol. 2, (1)
Gennebäck, Nina; Wikström, Gerhard; Hellman, Urban; et al.
Amyloid: Journal of Protein Folding Disorders, Vol. 19, (S1) : 53-54
Hellman, Urban; Suhr, Ole B
Glycobiology, Oxford: Oxford University Press 2012, Vol. 22, (1) : 7-11
Malm, Linus; Hellman, Urban; Larsson, Göran
PLOS ONE, Public Library of Science 2012, Vol. 7, (4) : e34653-
Waldenström, Anders; Gennebäck, Nina; Hellman, Urban; et al.
European Journal of Human Genetics
Bonaïti, Bernard; Olsson, Malin; Hellman, Urban; et al.
PLOS ONE, Vol. 5, (12) : e14393-
Hellman, Urban; Malm, Linus; Ma, Li-Ping; et al.
Genomics, Vol. 96, (2) : 73-81
Hellman, Urban; Mörner, Stellan; Engström-Laurent, Anna; et al.
Clinical Genetics, Vol. 75, (2) : 163-168
Olsson, Malin; Hellman, Urban; Planté-Bordeneuve, V; et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 15, (3) : 181-6
Hellman, Urban; Alarcon, Flora; Lundgren, Hans-Erik; et al.
Cell and Tissue Research, Vol. 332, (1) : 49-56
Hellman, Urban; Hellström, Martin; Mörner, Stellan; et al.
Annals of Human Genetics, Vol. 72, (Pt 4) : 478-84
Zaros, C; Genin, E; Hellman, Urban; et al.
Acta Odontologica Scandinavica, Vol. 64, (2) : 111-114
Gu, Xiaolian; Bäckman, Birgitta; Coates, Philip J; et al.
Amyloid, Vol. 12, (3) : 184-8
Holmgren, Gösta; Hellman, Urban; Anan, Intissar; et al.
Amyloid, Vol. 12, (3) : 189-92
Holmgren, Gösta; Hellman, Urban; Jonasson, Jenni; et al.
Journal of Medical Genetics, Vol. 42, (12) : 953-6
Holmgren, Gösta; Hellman, Urban; Lundgren, Hans-Erik; et al.
Journal of Internal Medicine, Vol. 258, (3) : 225-230
Mörner, Stellan; Hellman, Urban; Suhr, Ole B; et al.
Journal of Molecular and Cellular Cardiology, Vol. 35, (7) : 841-849
Mörner, Stellan; Richard, Pascale; Kazzam, Elsadig; et al.
Neurology, Lippincott Williams & Wilkins 2002, Vol. 59, (11) : 1804-1807
Carlsson, Anna; Forsgren, Lars; Nylander, P-O; et al.
Hellman, Urban; Ronquist, Gunnar; Waldenström, Anders