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Staff photo Urban Hellman

Urban Hellman

My research interest is the metabolism of hyaluronan in inflammation and tissue growth.

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Affiliation
Senior research engineer at Department of Public Health and Clinical Medicine Units: Section of Medicine
Location
Byggnad 6M, 3tr (M 31), Norrlands universitetssjukhus, rum 5030

2010 I defended my thesis on hyaluronan in cardiac hypertrophy. I am researching hereditary heart diseases, rheumatic diseases and metabolic diseases and supervising students at the lab. I also work at Norrland University Hospital at Heart Center and the Centre for Cardiovascular Genetics as a healthcare developer. 

My research interest is the significance of extracellular matrix in growth and inflammation in pathological and healthy tissue. The metabolism of the glycosaminoglycan hyaluronan and its involvement of energy metabolism and glucose have evolved into my research focus. Over the years, I have studied hyaluronan metabolism in hypertrophic cardiomyopathy, psoriasis arthritis, pancreatic cancer, ankylosing spondylitis, systemic lupus erythematosus, keloid, scleroderma, respiratory papilloma and developed new methods for analysis of hyaluronan.

Together with Göran Larsson, we are now developing a method to protect hyaluronan against degradation and inhibit the emergence of bioactive fragments, which are part of the inflammatory process.
During 2018, I worked at the department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, USA. We developed a method for concentration and sizing measurements of hyaluronan. At the Matrix Biology Institute, New Jersey, I studied how elevated concentration of hyaluronan around cultured cardiomyocytes affects their contractions negatively and thereby causes a potential arrhythmia risk.

I also help Andreas Josefsson, WCMM, with hyaluronan analysis in his project on prostate cancer and circulating tumor cells. Hyaluronan interaction with transthyretin in the heart of amyloidosis is another interest I have together with Intissar Anan, WCMM/Medicine, Malin Olsson at the division of Medicine and Anders Olofsson, Medical biochemistry and biophysics.

2020
Journal of Biological Chemistry
Hellman, Urban; Karlsson, Mats G.; Engström-Laurent, Anna; et al.
2019
Journal of Pathology, John Wiley & Sons 2019, Vol. 5, (2) : 130-141
Franklin, Oskar; Billing, Ola; Öhlund, Daniel; et al.
2019
Scandinavian Journal of Rheumatology, Taylor & Francis Group 2019, Vol. 48, (4) : 284-293
Hellman, Urban; Engström-Laurent, Anna; Larsson, Anders; et al.
2019
Scandinavian Journal of Clinical and Laboratory Investigation, Taylor & Francis 2019, Vol. 79, (6) : 372-376
Hellman, Urban; Lång, Kenneth; Ihse, Elisabet; et al.
2019
Medicine (Baltimore, Md.), Wolters Kluwer 2019, Vol. 98, (15)
Hellman, Urban; Mörner, Stellan; Henein, Michael
2019
Cells, MDPI 2019, Vol. 8, (2)
Lorén, Christina; Dahl, Christen P.; Do, Lan; et al.
2018
Acta Oto-Laryngologica, Taylor & Francis 2018, Vol. 138, (11) : 1020-1027
Holm, Anna; Hellman, Urban; Laurent, Claude; et al.
2018
Clinical and Experimental Rheumatology, CLINICAL & EXPER RHEUMATOLOGY 2018, Vol. 36, (4) : 716-716
Kumar, A.; Do, Lan; Hellman, Urban; et al.
2018
Clinical and Experimental Rheumatology, Vol. 36, (4) : 716-716
Kumar, Anjani; Do, Lan; Hellman, Urban; et al.
2016
Connective Tissue Research, Taylor & Francis 2016, Vol. 57, (5) : 337-346
Kerje, Susanne; Hellman, Urban; Do, Lan; et al.
2016
Journal of Voice, Vol. 30, (3) : 255-262
Opheim, Leif Runar; Hellman, Urban; Engström-Laurent, Anna; et al.
2016
PLoS ONE, Public Libray Science 2016, Vol. 11, (7)
Svennerholm, Kristina; Rodsand, Pouria; Hellman, Urban; et al.
2015
European Journal of Medical Genetics, Vol. 58, (4) : 211-215
Hellman, Urban; Lundgren, Hans-Erik; Westermark, Per; et al.
2015
International Journal of Cardiology Heart and Vasculature, Elsevier 2015, Vol. 8 : 62-67
Svennerholm, Kristina; Rodsand, Pouria; Hellman, Urban; et al.
2014
International Cardiovascular Forum Journal, Barcaray International Publishing 2014, Vol. 1, (5) : 226-229
Hellman, Urban
2013
Journal of Extracellular Vesicles, Co-action publishing 2013, Vol. 2
Gennebäck, Nina; Hellman, Urban; Malm, Linus; et al.
2012
Cardiogenetics, Vol. 2, (1)
Gennebäck, Nina; Wikström, Gerhard; Hellman, Urban; et al.
2012
Amyloid: Journal of Protein Folding Disorders, Vol. 19, (S1) : 53-54
Hellman, Urban; Suhr, Ole B
2012
Glycobiology, Oxford: Oxford University Press 2012, Vol. 22, (1) : 7-11
Malm, Linus; Hellman, Urban; Larsson, Göran
2012
PLoS ONE, Public Library of Science 2012, Vol. 7, (4) : e34653-
Waldenström, Anders; Gennebäck, Nina; Hellman, Urban; et al.
2010
European Journal of Human Genetics
Bonaïti, Bernard; Olsson, Malin; Hellman, Urban; et al.
2010
PLoS ONE, Vol. 5, (12) : e14393-
Hellman, Urban; Malm, Linus; Ma, Li-Ping; et al.
2010
Genomics, Vol. 96, (2) : 73-81
Hellman, Urban; Mörner, Stellan; Engström-Laurent, Anna; et al.
2009
Clinical Genetics, Vol. 75, (2) : 163-168
Olsson, Malin; Hellman, Urban; Planté-Bordeneuve, V; et al.
2008
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 15, (3) : 181-6
Hellman, Urban; Alarcon, Flora; Lundgren, Hans-Erik; et al.
2008
Cell and Tissue Research, Vol. 332, (1) : 49-56
Hellman, Urban; Hellström, Martin; Mörner, Stellan; et al.
2008
Annals of Human Genetics, Vol. 72, (Pt 4) : 478-84
Zaros, C; Genin, E; Hellman, Urban; et al.
2006
Acta Odontologica Scandinavica, Vol. 64, (2) : 111-114
Gu, Xiaolian; Bäckman, Birgitta; Coates, Philip J; et al.
2005
Amyloid, Vol. 12, (3) : 184-8
Holmgren, Gösta; Hellman, Urban; Anan, Intissar; et al.
2005
Amyloid, Vol. 12, (3) : 189-92
Holmgren, Gösta; Hellman, Urban; Jonasson, Jenni; et al.
2005
Journal of Medical Genetics, Vol. 42, (12) : 953-6
Holmgren, Gösta; Hellman, Urban; Lundgren, Hans-Erik; et al.
2005
Journal of Internal Medicine, Vol. 258, (3) : 225-230
Mörner, Stellan; Hellman, Urban; Suhr, Ole B; et al.
2003
Journal of Molecular and Cellular Cardiology, Vol. 35, (7) : 841-849
Mörner, Stellan; Richard, Pascale; Kazzam, Elsadig; et al.
2002
Neurology, Lippincott Williams & Wilkins 2002, Vol. 59, (11) : 1804-1807
Carlsson, Anna; Forsgren, Lars; Nylander, P-O; et al.
Hellman, Urban; Ronquist, Gunnar; Waldenström, Anders