Wallenberg Molecular Medicine Fellow: Infection Biology
The viral infectious cycle begins and ends with cell surface interactions, from finding the target cell for infection to the escape of viral progeny. These interactions are complex dynamic processes requiring a series of fine-tuned biomolecular recognition events which play an essential role in modulating the multitude of physiological processes that occur at the cell surface. Understanding the mechanisms that underlie how viruses interact with the cell surface is essential to designing anti-viral therapies. To elucidate these mechanisms, my group adopts a multidisciplinary approach combining traditional cell studies used in the field of virology with advanced biophysical approaches relying on in vitrocell-surface mimics and live-cell microscopy. In particular, my group is currently focused on the mechanisms modulating the binding and release of Herpes Simplex Virus from cell-surface carbohydrates. We are also developing biosensor platforms for the testing of anti-viral drugs.