Colorectal cancer (CRC) is globally the third most common cancer type and over 6000 people receive the diagnosis yearly in Sweden. 30-35% of patients with colorectal cancer will develop liver metastases (CLM) and for those patients, the only hope of a lasting cure is that the metastases can be surgically removed.
CLM can grow with three different metastatic growth patterns (GP) in the liver and these patterns have been linked to prognosis after liver surgery and they also might determine how well the tumour responds to oncological treatment.
One of our goals is to find a way to classify the growth pattern in CLM in patients prior surgery using modern imaging and biomarkers. A second goal is to investigate how the transcriptome differs between the GP and if this hopefully new molecular insight can be used for the development of targeted oncological and surgical therapy.
Lastly we want to understand if these molecular differences can be seen already in the primary tumour of CRC.