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Extra Seminarium Himanshu Sharma

tis
28
maj
Tid Tisdag 28 maj, 2019 kl. 11:15 - 11:45
Plats Thymine, Molekylärbiologi

MIMS/ Molekylärbiologi - Extra seminarium

Talare:
Himanshu Sharma

Indian Institute of Technology Guwahati, Assam, India

Titel:
Ribosome assembly defects abrogate initiation factor mediated inspection of start codon

Värd: Jonas Barandun, MIMS group leader, SciLifelab National Fellow, Institutionen för molekylärbiologi

Abstrakt:
Faithful protein synthesis is ensured by extensive quality control checkpoints using components of the translational machinery. However, the implications of defective ribosome assembly on protein synthesis and the associated translation quality control mechanisms in bacteria remain grossly unaddressed. In this study, using E. coli as a model organism we show that premature ribosomes evade scrutiny of cognate start Codon by initiation factors during translation initiation. Resultantly the defective ribosomes make way into the translation cycle with severely compromised decoding and protein synthesis capabilities. The enfeebled binding of premature ribosomes to initiation factors also licenses the rapid conversion of the 30S (pre) initiation complex to 70S initiation complex. Overall, our work highlights that a mass balance deficit between premature ribosomes and initiation factors steers the entry of premature ribosomes into the translation cycle.

(Medförfattare: B. Anand)

 

Evenemangstyp: Seminarium
Kontaktperson
Jonas Barandun
Läs om Jonas Barandun