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Published: 2022-10-19

Cryo-EM was the topic for UCMR Distinguished Guest Seminar

NEWS Within the framework of UCMR Distinguished Guests Seminars Series, professor Edward Egelman from the University of Virginia in USA paid a visit to Umeå University. He gave an interesting lecture on cryo-electron microscopy (Cryo-EM), which today has become the main technique for determining the atomic structure of macromolecules.

Text: Ingrid Söderbergh

The cryo-EM facility here is world-class!

“It was a great pleasure to visit both Umeå and the University. I was shown several laboratories and facilities. The atmosphere at the University was stimulating! It would be hard to pick one highlight, but the cryo-EM facility here is world-class!,” says Edward Egelman, Harrison Distinguished Professor of Biochemistry and Molecular Genetics, University of Virginia, USA

Edward Egelman is a biophysicist known for his work on the structure and function of protein and nucleoprotein polymers. He developed the algorithm that is now widely used in cryo-electron microscopy for the three-dimensional reconstruction of helical filaments and tubes.

In his seminar, Edward Egelman discussed applications of cryo-EM to a range of polymers, including bacterial and archaeal pili, bacterial and archaeal flagella, bacterial and archaeal mating pili, extracellular cytochrome filaments that conduct electrons over long distances (“microbial nanowires”) and filamentous viruses that infect hosts living in nearly boiling acid.

Edward Egelman’s host was Magnus Andersson, professor at the Department of Physics at Umeå University. He arranged a a solid scientific program where Edward Egelman got to meet principle investigators within UCMR; Elisabeth Sauer-Eriksson, David Cisneros Armas, Bernt Eric Uhlin, Sun Nyunt Wai, and Lars-Anders Carlson.

"During my stay in Umeå I have made some new connections, and I hope to have future interactions with a number of people I met," says Edward Egelman.