NEWS Within the framework of the UCMR Distinguished Guests Seminars Series, Felix Randow gives a lecture on how cells defend their cytosol against invasive bacteria.
Felix Randow, molecular immunologist and tenured group leader at the MRC Laboratory of Molecular Biology in Cambridge.
ImageCambridge UniversityTime: 23 November 14:30-15:30
Venue: Lilla hörsalen, KBC
Felix Randow, group leader at MRC Laboratory of Molecular Biology at Cambridge University
Intracellular pathogens colonize specific subcellular niches determined by their requirement for host-derived nutrients and antagonized by compartment-specific immunity. Most intracellular bacteria dwell in phagosomes and only few species have succeeded in conquering the cytosol, a perhaps counterintuitive situation given the abundance of nutrients freely available in the cytosol. Potent cytosolic defence mechanisms must therefore exist.
I will discuss how cells defend their cytosol against bacterial invasion through autophagy, triggered either upon sensing membrane damage caused by bacterial entry into the cytosol or through the deposition of ubiquitin on the bacterial surface.
Felix Randow is originally from Germany. He obtained his PhD from Humboldt University Berlin before moving to Boston where he was a post-doc with Brian Seed at Harvard Medical School. In 2003, Felix became Group Leader at MRC Laboratory of Molecular Biology at Cambridge University. Since 2022 he is Director of Research “Molecular Immunity”, at the Department of Medicine, Cambridge University.
https://www2.mrc-lmb.cam.ac.uk/groups/randow/Felix_Randow_Lab.html
