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Published: 2025-11-17

Harshit Malhotra develops new tools for synthetic biology

NEWS After earning his PhD in India, Harshit Malhotra has moved to Umeå, where he works as a 'Excellence by Choice' postdoctoral researcher developing advanced chemo-optogenetic tools. His research aims to control bacterial cellular processes and reprogram them to produce valuable chemicals.

What is your academic background?

"My doctoral work focussed on the metabolic engineering of the unique bacterium Pseudomonas bharatica CSV86T to degrade the toxic pesticide Carbaryl.  The bacterium, isolated from petrol-contaminated soil, has a broad metabolic diversity and unique carbon utilization property, making it ideal for biodegradation and metabolic engineering applications."

"Through this work, I gained expertise in microbiology, molecular biology, biochemistry, and metabolic engineering."

How did you end up at Umeå University in North Sweden?

"Profesoor Yaowen Wu lab at Umeå University has developed unique tools that find application in metabolic engineering and hold immense potential in revolutionising synthetic biology. This fact draw my attention."

What is your research focusing on?

"My research focusses on the development of chemo-optogenetic tools to control cellular processes in bacteria. These systems combine chemical molecules, optics, and genetically modified proteins to precisely control protein activities at specific locations in cells using light-sensitive small molecules."

What is challenging and rewarding respectively with being a researcher? 

"The challenge of being a researcher lies in the persistent effort, patience, and resilience required to uncover the truths of nature. However, this pursuit is deeply fulfilling, as it contributes to the advancement of human knowledge and progress."

What are your first impressions of Umeå and its university? 

"The city is very close to nature and serene. The work environment is conducive to the career development of researchers and provides wide range of scientific facilities for project implement."

What is your driving force to do research in life science?

"Contributing to society by harnessing the potential of synthetic biology."

Short facts about Harshit:

Coming from: Mumbai in India

Is exciting about my research: Rewiring microbes to produce valuable chemicals.

In my free time: read or go for a run

On the bedside: The Sixth Extinction by Elizabeth Kolbert

Favourite holiday spot: Mangaluru in India

On my bucket list: Travel to Madagascar

For more information, please contaact:

Harshit Malhotra
Postdoctoral position
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