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Image: Mattias Pettersson

Andre Mateus lab

Research group The André Mateus lab is interested in understanding how proteins function and interact in the species of the human gut microbiome.

The gut microbiome plays fundamental roles to maintain human health. Multiple diseases are now associated with imbalances in gut microbiome composition, but their mechanisms are still not clear. We focus on mapping and modulating protein function and interactions in these species. For this, we use systems biology approaches by perturbing cells (using drugs or genetic manipulation) and measuring the outcome on the state of the proteome. This allows us to not only link functionally related proteins, but also to understand how drugs act and what are their mechanisms of resistance. Further, we are interested in the metabolism of these organisms, for example, which proteins are important to metabolize certain nutrients.

By integrating this knowledge, we hope that we will be able to understand how the species of the microbiome interact between themselves and how stable communities are formed. In the future, this should open the door to establish strategies to manipulate gut microbiome composition towards a healthy state.


More information


Head of research

Andre Mateus
Assistant professor, other position


Participating departments and units at Umeå University

Department of Chemistry

Research area

Chemical sciences, Infection biology

External funding

The Kempe Foundation, ERC - European Research Council, Swedish Research Council, Knut and Alice Wallenberg Foundation

External funding

André Mateus
Proteomics – a powerful discovery tool

André Mateus had a seminar on everything you ever wanted to know about proteomics, but never dared to ask.

Two Umeå researchers appointed Wallenberg Academy Fellows

Nicolò Maccaferri and André Mateus have been appointed Wallenberg Academy Fellows.

UCMR PI new board member in proteomics society

André Mateus is a new board member of the Swedish Proteomics Society, SPS.

Latest update: 2023-06-20