Research project The main route for uptake of occupational exposure agents is inhalation. However, over time the air levels measured at different work places have decreased and therefore the importance of dermal exposures have increased.
Isocyanates used in paints, plastics and glues, are strong sensitizers. The aim of this study is to develop methods for measuring dermal exposure among workers exposed to isocyanates, especially MDI. The high reactivity of isocyanates render them to react with proteins in the skin. This may lead to the development of allergic dermatitis. The results will aid in the development of future studies in exposure modelling, including inhalation and dermal exposure, biomarkers, and exposure determinants.
Finansår , 2006
huvudman: Umeå universitet, finansiar: FAS, y2006: 750,