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You are welcome to contact us at mission-o@regionvasterbotten.se with questions regarding our study.
Research project The aim of this study is to estimate the impact of opportunistic salpingectomy on onset of menopause.
Most ovarian cancers (OC) are now believed to arise from the Fallopian tube. Removing Fallopian tubes at other gynaecologic procedures i.e., opportunistic salpingectomy (OS), is advocated for OC prevention. Previous research has evaluated surgical safety and menopausal symptoms after OS. However, the impact of OS on age at menopause remains unknown as high-quality prospective trial data are lacking. This is critically important, as early menopause and its associated hormonal transition have significant detrimental long-term health consequences.
Our randomised trial “Hysterectomy and opportunistic salpingectomy” (HOPPSA) evaluates surgical safety and menopausal symptoms after OS. However, the impact of OS on age at menopause remains unknown as high-quality prospective trial data are lacking. This is critically important, as early menopause and its associated hormonal transition have significant detrimental long-term health consequences.
Women in HOPPSA (2,700) will be invited to donate blood samples twice: 1-8 and 2-9 years post-surgery. Sampling will be performed by self-sampling of capillary blood on Dried Blood Spot cards. Differences in serum Follicle stimulating hormone (FSH) distribution between arms will be used to estimate impact on menopause, adjusted for age and time to blood sampling. The mean age difference will be estimated by modelling, using control FSH levels from the Women’s Health Across the Nation (SWAN) cohort study.
Our study will provide high-quality prospective evidence on impact of OS at hysterectomy on menopausal age. Critically, this will inform clinical guidelines and decision-making for women considering OS in Sweden and world-wide.
You are welcome to contact us at mission-o@regionvasterbotten.se with questions regarding our study.