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Staff photo Karl-Fredrik Norrback

Karl-Fredrik Norrback

Works at

Affiliation
Affiliated as research fellow at Department of Clinical Sciences Units: Psychiatry
Location
23, våning 5, Psykiatriska kliniken Umeå universitet, Psykiatri, 901 85 Umeå

Background
I was born in 1972. I got my PhD in Medicine at Umeå University, department of Medical Biosciences with the dissertation "Telomeres and telomerase in normal and malignant hematopoietic cells" in 2000. I received my MD in 2004, Umeå University and I have since then performed research at the department of Clinical Sciences, Psychiatry. I became an associate professor of Experimental Psychiatry in 2013.

Research partners
My main collaborator has been Professor Rolf Adolfsson (the psychiatry unit). Other important collaborators throughout my research; Professor Göran Roos (Umeå University), Professor Lars-Göran Nilsson (Stockholm University) and Professor Jurgen Del-Favero (Antwerp University).

Three major research areas of mine

1. Telomere biology
Research on telomeres which are repetitive DNA-sequences capping the chromosomes was awarded the Nobel Prize in 2009. Telomeres are believed to influence the aging process and to provide information pertaining to the biological age. Most recently, I have been investigating the biomarker value of the telomere length pertaining to structural and functional measures of the brain. See also the doctoral dissertation "Telomeres and the brain" (2011) by Mikael Wikgren (I was the main supervisor).

2. Causes and effects of stress and stress-dysregulation.
The research is focused at understanding the causes and effects of stress and stress-dysregulation in the general population and in affective disorders. We have a particular interest in investigating one of the body's most central stress-coping systems; the HPA-axis and its effector molecule cortisol. See also the doctoral dissertation "Hypocortisolism in recurrent affective disorders" (2015) by Martin Maripuu (I was the main supervisor).

3. Psychosomatics
One psychosomatic condition studied is IBS which shows comorbidity with affective disorders, stress and inflammation. The pathophysiology of IBS is however largely unknown. We also study chronic pain from which many suffer often without medical doctors being able to identify specific causes. We investigate the role of stress- and mood-dysregulation for the etiology and the expression of these conditions. See also the doctoral dissertation "The emotional motor system and gastrointestinal symptoms" (2008) by Pontus Karling (I was co-supervisor).

Teaching
I have taught on a diverse number of subjects within the following university programs at Umeå University, e.g.: the programs of medicin, dentistry, biomedicine, science in environmental health, speech and language pathology. I have tutored PhD-students since 2005.

Neurology, psychiatry and brain research, Elsevier 2019, Vol. 34 : 34-40
Maripuu, Martin; Norrbäck, Karl-Fredrik; Adolfsson, Rolf
Journal of Affective Disorders, ELSEVIER SCIENCE BV 2017, Vol. 213 : 161-167
Maripuu, Martin; Wikgren, Mikael; Karling, Pontus; et al.
Schizophrenia Research, Vol. 17, (1-3) : 68-74
Forero, Diego A.; Herteleer, Liesbet; De Zutter, Sonia; et al.
World Journal of Gastroenterology, Baishideng 2016, Vol. 22, (38) : 8540-8548
Karling, Pontus; Maripuu, Martin; Wikgren, Mikael; et al.
Journal of Depression & Anxiety, Longdom Publishing 2016, Vol. 5, (4)
Karling, Pontus; Maripuu, Martin; Wikgren, Mikael; et al.
Journal of neurogastroenterology and motility, Vol. 22, (2) : 292-303
Karling, Pontus; Wikgren, Mikael; Adolfsson, Rolf; et al.
Psychoneuroendocrinology, Vol. 71 : 64-65
Maripuu, Martin Peter; Wikgren, Mikael; Karling, Pontus; et al.
Journal of Affective Disorders, Vol. 204 : 187-196
Maripuu, Martin; Wikgren, Mikael; Karling, Pontus; et al.
Journal of Psychosomatic Research, Vol. 85 : 73-74
Maripuu, Martin; Wikgren, Mikael; Karling, Pontus; et al.
Age and Ageing, Vol. 43, (2) : 212-217
Wikgren, Mikael; Karlsson, Thomas; Söderlund, Hedvig; et al.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 159B, (7) : 812-822
Van Den Bossche, Maarten J.; Johnstone, Mandy; Strazisar, Mojca; et al.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 159B, (4) : 465-475
Van Den Bossche, Maarten J.; Strazisar, Mojca; De Bruyne, Stephan; et al.
PLOS ONE, Public Library of Science 2012, Vol. 7, (4) : e34292-
Wikgren, Mikael; Karlsson, Thomas; Lind, Johanna; et al.
Neurobiology of Aging, Elsevier 2012, Vol. 33, (2) : 335-344
Wikgren, Mikael; Karlsson, Thomas; Nilbrink, Therese; et al.
Biological Psychiatry, New York: Plenum 2012, Vol. 71, (4) : 294-300
Wikgren, Mikael; Maripuu, Martin; Karlsson, Thomas; et al.
Bipolar Disorders, Malden, USA: Wiley-Blackwell 2011, Vol. 13, (7-8) : 614-623
Ceulemans, Shana; De Zutter, Sonia; Heyrman, Lien; et al.
PloS one, Public Library of Science 2011, Vol. 6, (3) : e18035-
Karling, Pontus; Danielsson, Åke; Wikgren, Mikael; et al.
PLOS ONE, Public Library of Science 2011, Vol. 6, (8)
Moens, Lotte N.; De Rijk, Peter; Reumers, Joke; et al.
Psychiatric Genetics, Lippincott Williams & Wilkins 2011, Vol. 21, (3) : 125-131
Van Schijndel, Jessica E.; Van Zweeden, Martine; Van Loo, Karen M. J.; et al.
American Journal of Medical Genetics, Vol. 153B, (6) : 1240-1243
Moens, Lotte N; Ceulemans, Shana; Alaerts, Maaike; et al.
European Journal of Human Genetics, Basel: Karger 2010, Vol. 18, (3) : 385-389
Nordfjäll, Katarina; Svenson, Ulrika; Norrback, Karl-Fredrik; et al.
Archives of General Psychiatry, Vol. 66, (8) : 828-837
Alaerts, Maaike; Ceulemans, Shana; Forero, Diego; et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 150B, (4) : 585-592
Alaerts, Maaike; Ceulemans, Shana; Forero, Diego; et al.
PLoS genetics, Public Library of Science 2009, Vol. 5, (2) : e1000375-
Nordfjäll, Katarina; Svenson, Ulrika; Norrback, Karl-Fredrik; et al.
Neurogastroenterology and Motility, Oxford: Blackwell 2007, Vol. 19, (11) : 896-904
Karling, Pontus; Danielsson, Åke; Adolfsson, Rolf; et al.
Scand J Gastroenterol, Vol. 42, (11) : 1294-1301
Karling, Pontus; Norrback, Karl-Fredrik; Adolfsson, Rolf; et al.
Psychiatry Research, Vol. 153, (1) : 17-25
Van Den Eede, Filip; Venken, Tine; Del-Favero, Jurgen; et al.
Psychiatric Genetics, Lippincott Williams & Wilkins 2007, Vol. 17, (5) : 304-307
Van Den Eede, Filip; Venken, Tine; Van Den Bogaert, Ann; et al.
Psychiatric Genetics, Lippincott Williams & Wilkins 2006, Vol. 16, (6) : 235-236
Alaerts, Maaike; Venken, Tine; Lenaerts, An-Sofie; et al.
Psychiatric Genetics, Lippincott Williams & Wilkins 2006, Vol. 16, (5) : 209-212
Van Den Bogaert, Ann; Sleegers, Kristel; De Zutter, Sonia; et al.
Archives of General Psychiatry, American Medical Association 2006, Vol. 63, (10) : 1103-1110
Van Den Bogaert, Ann; Sleegers, Kristel; De Zutter, Sonia; et al.
Neuropsychopharmacology, Nature Publishing Group 2006, Vol. 31, (3) : 620-627
van West, Dirk; Van Den Eede, Filip; Del-Favero, Jurgen; et al.
International Journal of Cancer, Geneve: International union against cancer 2005, Vol. 116, (3) : 395-400
Palmqvist, Richard; Zhang, Anju; Xu, Dawei; et al.
British Journal of Cancer, Vol. 88, (4) : 593-8
Hultdin, M; Rosenquist, R; Thunberg, U; et al.
British Journal of Cancer, London: Nature Publishing Group 2003, Vol. 88, (4) : 593-598
Hultdin, Magnus; Rosenquist, R; Thunberg, U; et al.
Experimental Cell Research, Elsevier 2001, Vol. 271 : 223-229
Hultdin, Magnus; Grönlund, Elisabeth; Norrback, Karl-Fredrik; et al.
European Journal of Haematology, Blackwell Munksgaard 2001, Vol. 67, (5-6) : 309-317
Norrback, Karl-Fredrik; Hultdin, Magnus; Dahlenborg, Katarina; et al.
British Journal of Cancer, Vol. 82, (3) : 601-607
Remes, K; Norrback, Karl-Fredrik; Rosenquist, R; et al.
Nucleic Acids Research, Oxford: Oxford University Press 1998, Vol. 26, (16) : 3651-3656
Hultdin, Magnus; Grönlund, Elisabeth; Norrback, Karl-Fredrik; et al.
Blood, Vol. 92, (2) : 567-573
Norrback, Karl-Fredrik; Enblad, Gunilla; Erlanson, Martin; et al.
European Journal of Cancer, Elsevier 1997, Vol. 33, (5) : 774-780
Norrback, Karl-Fredrik; Roos, Göran
Blood, Vol. 88, (1) : 222-229
Norrback, Karl Fredrik; Dahlenborg, Katarina; Carlsson, Roland; et al.