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Staff photo Ludmilla Morozova-Roche

Ludmilla Morozova-Roche

Amyloid formation - from molecular mechanisms to disease and novel nanomaterials

Works at

Affiliation
Location
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Protein self-association into amyloid oligomers and fibrils and their deposition in the body is a hallmark of a number of human pathologies including Alzheimer's and Parkinson's diseases, diabetes mellitus and others. We study in depth the multiple faces of this phenomenon, including structural and regulatory mechanisms governing amyloid formation in vivo and in vitro , cytotoxicity of amyloids and misfolded protein complexes towards normal and tumor cells, immune response to them in the biological fluids of Alzheimer's and Parkinson's disease patients as well as the applications of amyloids as novel nanomaterials in nanobiotechnology.

2019
PLoS ONE, PUBLIC LIBRARY SCIENCE 2019, Vol. 14, (2)
Huang, Qin; Sun, Dan; Hussain, Muhammad Zubair; et al.
2019
ACS Chemical Biology, AMER CHEMICAL SOC 2019, Vol. 14, (7) : 1410-1417
Pansieri, Jonathan; Ostojic, Lucija; Iashchishyn, Igor; et al.
2019
Neuroscience Letters, ELSEVIER IRELAND LTD 2019, Vol. 699 : 199-205
Wang, Chao; Iashchishyn, Igor; Kara, John; et al.
2019
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 338A-338A
Williamson, Philip T. F.; Horrocks, Jack; Maheswaran, Luckshi; et al.
2018
Journal of Neuroinflammation, BioMed Central 2018, Vol. 15
Horvath, Istvan; Iashchishyn, Igor; Moskalenko, Roman A.; et al.
2018
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (6) : 1338-1348
Iashchishyn, Igor A.; Gruden, Marina A.; Moskalenko, Roman A.; et al.
2018
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Wang, Chao; Iashchishyn, Igor; Pansieri, Jonathan; et al.
2017
Chemical Science, ROYAL SOC CHEMISTRY 2017, Vol. 8, (12) : 8247-8254
Baldassarre, Maurizio; Baronio, Cesare M.; Morozova-Roche, Ludmilla A.; et al.
2017
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
2017
Cell reports, Vol. 18, (9) : 2077-2087
Goldberg, Emily L.; Asher, Jennifer L.; Molony, Ryan D.; et al.
2017
Bulletin of experimental biology and medicine, SPRINGER 2017, Vol. 162, (4) : 430-432
Gruden, M. A.; Davydova, T. V.; Fomina, V. G.; et al.
2017
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (6) : 1170-1176
Horvath, Istvan; Iashchishyn, Igor A.; Forsgren, Lars; et al.
2017
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (10) : 2152-2158
Iashchishyn, Igor A.; Sulskis, Darius; Ngoc, Mai Nguyen; et al.
2016
Scientific Reports, Vol. 6
Baumann, Anne; Jorge-Finnigan, Ana; Jung-KC, Kunwar; et al.
2016
Behavioural Brain Research, Vol. 306 : 106-116
Gruden, Marina A.; Davydova, Tatiana V.; Wang, Chao; et al.
2016
ACS Chemical Neuroscience, Vol. 7, (1) : 34-39
Horvath, Istvan; Jia, Xueen; Johansson, Per; et al.
2016
Experimental Eye Research, Vol. 152 : 1-9
Minkevich, Natalya I.; Morozova-Roche, Ludmilla A.; Iomdina, Elena N.; et al.
2016
International Journal of Molecular Medicine, Spandidos 2016, Vol. 38 : S28-S28
Morozova-Roche, Ludmilla
2015
Behavioural Brain Research, Vol. 279 : 191-201
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
2014
PLoS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
2014
Journal of Physical Chemistry Letters, Vol. 5, (18) : 3254-3258
Fodera, Vito; Vetri, Valeria; Wind, Thea S.; et al.
2014
Behavioural Brain Research, Elsevier 2014, Vol. 263 : 158-168
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
2014
Journal of Neuroimmunology, Vol. 268, (1-2) : 99-99
Gruden, Marina A.; Sewell, Robert D. E.; Yanamandra, Kiran; et al.
2014
ChemBioChem (Print), Wiley-VCH Verlagsgesellschaft 2014, Vol. 15, (18) : 2693-2702
Kaspersen, Jørn D.; Pedersen, Jannik N.; Hansted, Jon G.; et al.
2014
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
2013
PLoS ONE, Public Library of Science 2013, Vol. 8, (11) : Article Number: UNSP e80649-
Clementi, Emily A.; Wilhelm, Kristina R.; Schleucher, Juergen; et al.
2013
PLoS ONE, Public Library of Science 2013, Vol. 8, (3) : e58218-
Eremenko, Ekaterina; Ben-Zvi, Anat; Morozova-Roche, Ludmilla A.; et al.
2013
Behavioural Brain Research, Vol. 243 : 205-212
Gruden, Marina A.; Davidova, Tatiana V.; Yanamandra, Kiran; et al.
2013
PLoS ONE, Public Library Science 2013, Vol. 8, (7) : e68912-
Vetri, Valeria; Leone, Maurizio; Morozova-Roche, Ludmilla A.; et al.
2013
Journal of Physical Chemistry B, American Chemical Society (ACS) 2013, Vol. 117, (28) : 8392-9
Xu, Weixin; Zhang, Ce; Morozova-Roche, Ludmilla; et al.
2013
RSC Advances, RSC Publishing 2013, Vol. 3, (46) : 24081-24089
Zhao, Li Na; Zhang, Tong; Zhang, Ce; et al.
2012
Journal of Biological Chemistry, Vol. 287, (50) : 42233-42242
Botelho, Hugo M.; Leal, Sonia S.; Cardoso, Isabel; et al.
2012
Chemical Science, Vol. 3, (12) : 3468-3473
Bryan, Thomas; Luo, Xiliang; Forsgren, Lars; et al.
2012
Amyloid Proteins: Methods and Protocols, Springer Science+Business Media B.V. 2012 : 387-401
Gharibyan, Anna; Raveh, Dina; Morozova-Roche, Ludmilla
2012
Neuroimmunomodulation, Vol. 19, (6) : 334-342
Gruden, Marina A.; Yanamandra, Kiran; Kucheryanu, Valery G.; et al.
2012
11th international conference on fundamental and applied aspects of physical chemistry. Society of physical chemistry of Serbia. 24-28 September 2012, Belgrade.
Morozova-Roche, Ludmilla
2012
New York: Nova Science Publishers, Inc. 2012
Morozova-Roche, Ludmilla; Berliner, Lawrence J.; Permyakov, Eugene A.
2012
Neurologi i Sverige, (4) : 74-78
Morozova-Roche, Ludmilla; Forsgren, Lars; Davis, Jason
2012
Nova Biomedical 2012
Permyakov, Eugene A.; Morozova-Roche, Ludmilla; Berliner, Lawrence J.
2012
International Journal of Molecular Sciences, Vol. 13, (3) : 2893-2917
Vogl, Thomas; Gharibyan, Anna; Morozova-Roche, Ludmilla
2012
Lipoproteins - Role in Health and Diseases, InTech 2012 : 663-674
Vukojevic, Vladana; Morozova-Roche, Ludmilla
2011
Journal of Neuroimmunology, Vol. 233, (1-2) : 221-227
Gruden, Marina A; Sewell, Robert D E; Yanamandra, Kiran; et al.
2011
Journal of Molecular Biology, Vol. 414, (5) : 699-712
Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.
2011
PLoS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e24329-
Xu, Weixin; Zhang, Ce; Derreumaux, Philippe; et al.
2011
PLoS One, Public Library of Science 2011, Vol. 6, (4) : e18513-
Yanamandra, Kiran; Gruden, Marina A; Casaite, Vida; et al.
2010
The FEBS Journal, Vol. 277, (22) : 4578-4590
Fritz, Günter; Botelho, Hugo M; Morozova-Roche, Ludmilla A; et al.
2010
Journal of Molecular Biology, Elsevier 2010, Vol. 396, (1) : 60-74
Malisauskas, Mantas; Weise, Christoph; Yanamandra, Kiran; et al.

Research groups

Head of research
Ludmilla Morozova-Roche

Research projects