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Staff photo Maréne Landström

Maréne Landström

My group and I are researching to develop new, better cancer drugs and predictive biomarkers for the development of aggressive cancers. Among other things, we use the CRISPR / Cas9 method.

Works at

Affiliation
Professor, senior consultant (attending) physician at Department of Medical Biosciences Units: Pathology
Location
By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå

I and my collegues investigate how transforming growth factor b (TGFb) and Wnt3a, which are growth factors, activate molecular mechanisms that prostate cancer and kidney cancer cells use to become aggressive and metastatic in both in vitro and in vivo models, as well as in clinical materials from patients.

We use advanced cell, molecular and tumor biological methods including CRISPR / Cas9 that enable us to ask specific scientific questions with high precision. Our long-term goal is to develop new and better cancer drugs that can prevent the ability of cancer cells to invade and metastasize, as well as predictive biomarkers for patients at risk of developing aggressive cancers. We are now investigating a potential new cancer drug that we have developed in collaboration with the SciLifeLab Drug Discovery Development platform.

Biomolecules, MDPI 2022, Vol. 12, (5)
Mallikarjuna, Pramod; Zhou, Yang; Landström, Maréne
International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (9)
Zymovets, Valeriia; Razghonova, Yelyzaveta; Rakhimova, Olena; et al.
Journal of Clinical Pathology, BMJ Publishing Group Ltd 2021, Vol. 74, (4) : 216-222
Tumkur Sitaram, Raviprakash; Landström, Maréne; Roos, Göran; et al.
Translational Oncology, Elsevier 2020, Vol. 13, (12)
Hollandsworth, Hannah M.; Schmitt, Verena; Amirfakhri, Siamak; et al.
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2020, Vol. 10
Rakhimova, Olena; Schmidt, Alexej; Landström, Maréne; et al.
iScience, Cell Press 2020, Vol. 23, (9)
Thakur, Noopur; Hamidi, Anahita; Song, Jie; et al.
Clinical Oncology and Research, Vol. 3, (3)
Tumkur Sitaram, Raviprakash; Landström, Maréne; Roos, Göran; et al.
EBioMedicine, Elsevier 2019, Vol. 45 : 192-207
Aripaka, Karthik; Gudey, Shyam Kumar; Zang, Guangxiang; et al.
The FASEB Journal, FEDERATION AMER SOC EXP BIOL 2019, Vol. 33, (12) : 13064-13067
Landström, Maréne; Liu, Jun
Cell Cycle, Taylor & Francis 2019, Vol. 18, (17) : 2141-2156
Mallikarjuna, Pramod; Tumkur Sitaram, Raviprakash; Aripaka, Karthik; et al.
Oncogene, Nature Publishing Group 2019, Vol. 38, (22) : 4215-4231
Zang, Guangxiang; Mu, Yabing; Gao, Linlin; et al.
OncoTarget, Impact Journals, LLC 2018, Vol. 9, (23) : 16297-16310
Mallikarjuna, Pramod; Tumkur Sitaram, Raviprakash; Landström, Maréne; et al.
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
OncoTarget, IMPACT JOURNALS LLC 2017, Vol. 8, (58) : 97703-97726
Gudey, Shyam Kumar; Sundar, Reshma; Heldin, Carl-Henrik; et al.
Science Signaling, American Association for the Advancement of Science 2017, Vol. 10, (486)
Hamidi, Anahita; Song, Jie; Thakur, Noopur; et al.
Cell reports, Cell Press 2017, Vol. 20, (8) : 1893-1905
Holst, Mikkel Roland; Vidal-Quadras, Maite; Larsson, Elin; et al.
OncoTarget, IMPACT JOURNALS LLC 2017, Vol. 8, (59) : 99205-99206
Song, Jie; Landström, Maréne
OncoTarget, Vol. 7, (1) : 279-292
Song, Jie; Mu, Yabing; Li, Chunyan; et al.
OncoTarget, Vol. 7, (24) : 35917-35931
Tumkur Sitaram, Raviprakash; Mallikarjuna, Pramod; Landström, Maréne; et al.
Current Cancer Drug Targets, Bentham Science 2015, Vol. 15, (9) : 751-751
Landström, Maréne
British Journal of Cancer, Vol. 112, (7) : 1223-1231
Mu, Yabing; Zang, Guangxiang; Engstrom, U.; et al.
Cell Cycle, Taylor & Francis 2015, Vol. 14, (4) : 554-565
Sundar, Reshma; Gudey, Shyam Kumar; Heldin, Carl-Henrik; et al.
Journal of Cell Biology, Vol. 210, (2) : 319-332
Yakymovych, Ihor; Yakymovych, Mariya; Zang, Guangxiang; et al.
Science Signaling, American Association for the Advancement of Science 2014, Vol. 7, (307)
Gudey, Shyam Kumar; Sundar, Reshma; Mu, Yabing; et al.
Future Oncology, London, UK: Future Medicine Ltd 2014, Vol. 10, (11) : 1853-1861
Gudey, Shyam Kumar; Wallenius, Anders; Landström, Maréne
Cell Cycle, Vol. 13, (15) : 2400-2414
Thakur, Noopur; Gudey, Shyam Kumar; Marcusson, Anders; et al.
Cancerforskning på nya vägar: en bok från Forskningens dag 2013, Medicinska fakulteten vid Umeå universitet, Umeå: Umeå universitet 2013 : 23-35
Landström, Marene
Molecular Biology of the Cell, American Society of Cell Biology, USA 2012, Vol. 23, (11) : 2109-2121
Ekman, Maria; Mu, Yabing; Lee, So Young; et al.
Journal of Biological Chemistry, Rockville Pike: The American Society for Biochemistry and Molecular Biology ( 2012, Vol. 287, (1) : 123-133
Hamidi, Anahita; von Bulow, Verena; Hamidi, Rosita; et al.
Toxicology Letters, Vol. 211 : S4-S4
Landström, Marene
Encyclopedia of Signaling Molecules, New York: Springer-Verlag New York 2012 : 1916-1921
Landström, Maréne; Sundar, Reshma
Cell and Tissue Research, Vol. 347, (1) : 11-20
Mu, Yabing; Gudey, Shyam Kumar; Landström, Marene
Nature Communications, London: Nature Publishing Group 2011, Vol. 2, (330) : 11-
Mu, Yabing; Sundar, Reshma; Thakur, Noopur; et al.
International Journal of Biochemistry and Cell Biology, Vol. 42, (5) : 585-589
Landström, Marene
Current Opinion in Cell Biology, Vol. 21, (2) : 166-176
Heldin, Carl-Henrik; Landström, Maréne; Moustakas, Aristidis
Future oncology (London, England), Vol. 5, (1) : 1-3
Thakur, Noopur; Sorrentino, Alessandro; Heldin, Carl-Henrik; et al.
Nature Cell Biology, Vol. 10, (10) : 1199-1207
Sorrentino, Alessandro; Thakur, Noopur; Grimsby, Susanne; et al.
Mallikarjuna, Pramod; Aripaka, Karthik; Tumkur Sitaram, Raviprakash; et al.
Mu, Yabing; Song, Jie; Zang, Guangxiang; et al.
Sundar, Reshma; Gudey, Shyam Kumar; Heldin, Carl-Henrik; et al.
Thakur, Noopur; Gudey, Shyam Kumar; Marcusson, Anders; et al.

Research groups

Genetically modified fish assisting in the fight against cancer

Marléne Landström's research could lead to better treatment and more effective drugs to treat prostate cancer.