Press photo

Per Zetterström

Contact

per.zetterstrom@umu.se

+46 90 785 29 50

Works as

Assistant professor, resident physician at Department of Medical Biosciences Section: Clinical Chemistry

By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

N-truncated superoxide dismutase-1 in cerebrospinal fluid is folded and active

Journal of Neurochemistry, John Wiley & Sons 2026, Vol. 170, (2)

Leykam, Laura; Forsberg, Karin M. E.; Andersen, Peter M.; et al.

N-truncated superoxide Dismutase-1 in cerebrospinal fluid is folded and active

Journal of Neurochemistry, John Wiley & Sons 2026, Vol. 170, (2)

Leykam, Laura; Forsberg, Karin M. E.; Andersen, Peter M.; et al.

Heterogeneous phenotype and cardiovascular comorbidities in Swedish patients with spinobulbar muscular atrophy

Journal of Neurology, Springer Berlin/Heidelberg 2026, Vol. 273, (1)

Roos, Anna-Karin; Forsberg, Simon; Stenvall, Erica; et al.

SOD1 protein content in human central nervous system and peripheral tissues

Journal of Neurochemistry, John Wiley & Sons 2025, Vol. 169, (6)

Leykam, Laura; Jonsson, Andreas P.; Forsberg, Karin M. E.; et al.

Pathology of three ALS patients with FUS variants, including one likely benign Q23L variant lacking FUS inclusions

Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (18) : 1553-1562

Stenvall, Erica; Åman Grönlund, Kornelia; Rohan, Zdenek; et al.

Diverse effects of coexpression of human SOD1 variants on motor neuron disease

Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (16) : 1380-1391

Tokuda, Eiichi; Leykam, Laura; Zetterström, Per; et al.

Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations

Neurobiology of Disease, Elsevier 2024, Vol. 202

Leykam, Laura; Forsberg, Karin; Nordström, Ulrika; et al.

Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS

Journal of Neurochemistry, John Wiley & Sons 2023, Vol. 164, (1) : 77-93

Nordström, Ulrika; Lang, Lisa; Ekhtiari Bidhendi, Elaheh; et al.

The motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1

Brain Communications, Oxford University Press 2023, Vol. 5, (1)

Park, Julien H.; Nordström, Ulrika; Tsiakas, Konstantinos; et al.

ALS kan vara en prionsjukdom: Inklusioner av felvecklat SOD1-protein tycks finnas hos patienter med alla typer av ALS

Läkartidningen, Läkartidningen Förlag AB 2020, Vol. 117

Forsberg, Karin; Tjust, Anton E.; Zetterström, Per; et al.

Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Acta neuropathologica communications, BMC 2020, Vol. 8, (1)

Lehmann, Manuela; Marklund, Matthew; Bolender, Anna-Lena; et al.

Phenotype in an Infant with SOD1 Homozygous Truncating Mutation

New England Journal of Medicine, Massachusetts Medical Society 2019, Vol. 381, (5) : 486-488

Andersen, Peter M.; Hempel, Maja; Santer, René; et al.

The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension

Acta Neuropathologica, New York: Springer 2019, Vol. 138, (1) : 85-101

Keskin, Isil; Forsgren, Elin; Lehmann, Manuela; et al.

Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis

Acta Neuropathologica, Springer 2018, Vol. 136, (6) : 939-953

Ekhtiari Bidhendi, Elaheh; Bergh, Johan; Zetterström, Per; et al.

Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease

Journal of Clinical Investigation, Vol. 126, (6) : 2249-2253

Ekhtiari Bidhendi, Elaheh; Bergh, Johan; Zetterström, Per; et al.

Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2015, Vol. 112, (14) : 4489-4494

Bergh, Johan; Zetterström, Per; Andersen, Peter M.; et al.

SOD1 aggregation in ALS mice shows simplistic test tube behavior

Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (32) : 9878-9883

Lang, Lisa; Zetterström, Per; Brännström, Thomas; et al.

Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis

Human Molecular Genetics, Vol. 22, (1) : 51-60

Graffmo, Karin S.; Forsberg, Karin; Bergh, Johan; et al.

Composition of soluble misfolded superoxide Dismutase-1 in murine models of Amyotrophic Lateral Sclerosis

Neuromolecular medicine, Vol. 15, (1) : 147-158

Zetterström, Per; Graffmo, Karin S.; Andersen, Peter M; et al.

Cytotoxicity of Superoxide Dismutase 1 in Cultured Cells Is Linked to Zn2+ Chelation

PLOS ONE, Vol. 7, (4) : e36104-

Johansson, Ann-Sofi; Vestling, Monika; Zetterström, Per; et al.

Misfolded superoxide dismutase-1 in amyotrophic lateral sclerosis

Umeå University medical dissertations, 1421

Zetterström, Per

Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients

Journal of Neurochemistry, Vol. 117, (1) : 91-99

Zetterström, Per; Andersen, Peter M; Brännström, Thomas; et al.

Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic ALS model mice

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (23) : 20130-20136

Zetterström, Per; Graffmo, Karin S; Andersen, Peter M; et al.

Functional features cause misfolding of the ALS-provoking enzyme SOD1

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2009, Vol. 106, (24) : 9667-9672

Nordlund, Anna; Leinartaitė, Lina; Saraboji, Kadhirvel; et al.

Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models

Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, (35) : 14157-14162

Zetterström, Per; Stewart, Heather G; Bergemalm, Daniel; et al.

Superoxide dismutase prions transmit fatal ALS to transgenic mice which do not spontaneously develop symptoms

Ekhtiari Bidhendi, Elaheh; Zetterström, Per; Andersen, Peter M.; et al.

High expression of wild-type human superoxide dismutase-1 gives a model of sporadic ALS

Forsberg, Karin; Graffmo, Karin S; Zetterström, Per; et al.

Enhanced protein misfolding in patient-derived models of amyotrophic lateral sclerosis

Forsgren, Elin; Lehmann, Manuela; Weygandt Mathis, Mackenzie; et al.

Low oxygen tension induces misfolding and aggregation of superoxide dismutase in ALS patient-derived motor neurons

Keskin, Isil; Forsgren, Elin; Andersen, Peter M.; et al.

N-truncated superoxide dismutase-1 in cerebrospinal fluid is folded and active

Leykam, Laura; Forsberg, Karin; Andersen, Peter M.; et al.

CSF SOD1 activity in tofersen treated ALS patients

Leykam, Laura; Forsberg, Karin; Konrad, Julian; et al.

Structure of soluble misfolded superoxide dismutase-1 in murine ALS models

Zetterström, Per; Graffmo, Karin S; Andersen, Peter M; et al.

View publications in DiVA

Research groups

Head of research

ALS Research Umeå

Head of research

Per Zetterström Lab

Research projects

1 January 2025 until 31 December 2030

PREVENT