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Umeå University
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Thomas Boren

Protein-carbohydrate interactions during health and disease

Research qualifications: Docent
0000-0001-5113-3303

Contact

E-mail
thomas.boren@umu.se
Phone
+46 90 786 93 60, +46 70 514 67 67

Works at

Affiliation
Professor at Department of Medical Biochemistry and Biophysics
Location
KB. A6, Campus, Umeå Umeå universitet, 901 87 Umeå

The gastric pathogen Helicobacter pylori express several attachment proteins to match the shifts in glycosylation patterns of the human stomach during persistent infection and chronic infection. The project aims to better understand how bacterial attachment proteins adapt to the individual host during infection.

Antimicrobial activity of two different types of silver nanoparticles against wide range of pathogenic bacteria
Nanomaterials, MDPI 2024, Vol. 14, (2)
Holubnycha, Viktoriia; Husak, Yevheniia; Korniienko, Viktoriia; et al.
Ferric quinate (QPLEX) inhibits the interaction of major outer membrane protein (MOMP) with the Lewis b (Leb) antigen and limits Campylobacter colonization in broilers
Frontiers in Microbiology, Frontiers Media S.A. 2023, Vol. 14
Okoye, Jennifer C.; Holland, Alexandria; Pitoulias, Matthaios; et al.
Synthesis of a B-antigen hexasaccharide, a B-lewis b heptasaccharide and glycoconjugates thereof to investigate binding properties of helicobacter pylori
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2023, Vol. 29, (16)
Reihill, Mark; Fournière, Viviane; Cheallaigh, Aisling Ní; et al.
Immunological effects of cerebral palsy and rehabilitation exercises in children
Brain, Behavior, and Immunity - Health, Elsevier 2021, Vol. 18
Sharova, Oleksandra; Smiyan, Oleksandr; Borén, Thomas
Recombinant mucin-type proteins carrying LacdiNAc on different O-glycan core chains fail to support H. pylori binding.
Molecular Omics, Royal Society of Chemistry 2020, Vol. 16, (3) : 243-257
Mthembu, Yolanda H.; Jin, Chunsheng; Padra, Médea; et al.
Helicobacter pylori-binding nonacid glycosphingolipids in the human stomach
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (44) : 17248-17266
Jin, Chunsheng; Barone, Angela; Boren, Thomas; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development
EBioMedicine, Vol. 24 : 205-215
Esberg, Anders; Sheng, Nongfei; Mårell, Lena; et al.
Dynamic Expression of the BabA Adhesin and Its BabB Paralog during Helicobacter pylori Infection in Rhesus Macaques
Infection and Immunity, AMER SOC MICROBIOLOGY 2017, Vol. 85, (6)
Hansen, Lori M.; Gideonsson, Pär; Canfield, Don R.; et al.
Host Determinants of Expression of the Helicobacter pylori BabA Adhesin
Scientific Reports, Vol. 7
Kable, Mary E.; Hansen, Lori M.; Styer, Cathy M.; et al.
The glycan receptors of Helicobacter pylori: decoding the pathways underlying gastric glycophenotype modulation
Glycobiology, Vol. 26, (12) : 1401-1402
Magalhaes, Ana; Marcos-Pinto, Ricardo; Gomes, Joana; et al.
Muc5ac gastric mucin glycosylation is shaped by FUT2 activity and functionally impacts Helicobacter pylori binding
Scientific Reports, Vol. 6
Magalhaes, Ana; Rossez, Yannick; Robbe-Masselot, Catherine; et al.
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Cell Host and Microbe, Vol. 19, (1) : 55-66
Moonens, Kristof; Gideonsson, Pär; Subedi, Suresh; et al.
Helicobacter pylori Strains from Duodenal Ulcer Patients Exhibit Mixed babA/B Genotypes with Low Levels of BabA Adhesin and Lewis b Binding
Digestive Diseases and Sciences, Vol. 61, (10) : 2868-2877
Saberi, Samaneh; Schmidt, Alexej; Eybpoosh, Sana; et al.
Analysis of a single Helicobacter pylori strain over a 10-year period in a primate model
International Journal of Medical Microbiology, Vol. 305, (3) : 392-403
Liu, Hui; Fero, Jutta B.; Mendez, Melissa; et al.
BabA Protein Expression and Lewis b Binding is Gene Locus-Dependent
Helicobacter, John Wiley & Sons 2015, Vol. 20, (Suppl. 1) : 111-111
Saberi, S.; Schmidt, Alexej; Kurdistani, Z. Karimi; et al.
HELICOBACTER PYLORI; MULTITALENTED ADAPTATION OF BINDING PROPERTIES
Anticancer Research, Vol. 34, (10) : 5840-5841
Boren, Thomas
A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization
Open Biology, Vol. 4, (1) : 130202-
Mahdavi, Jafar; Pirinccioglu, Necmettin; Oldfield, Neil J.; et al.
Antiadhesive Properties of Arabinogalactan Protein from Ribes nigrum Seeds against Bacterial Adhesion of Helicobacter pylori
Molecules, Vol. 19, (3) : 3696-3717
Messing, Jutta; Niehues, Michael; Shevtsova, Anna; et al.
Antiadhesive Properties of Abelmoschus esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion
PLOS ONE, Public Library of Science 2014, Vol. 9, (1) : e84836-
Messing, Jutta; Thoele, Christian; Niehues, Michael; et al.
Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand
Journal of the Royal Society Interface, The Royal Society 2014, Vol. 11, (101) : UNSP 20141040-
Parreira, P.; Shi, Q.; Magalhaes, A.; et al.
Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA
Acta Crystallographica Section F: Structural Biology Communications, Vol. 70 : 1631-1635
Subedi, Suresh; Moonens, Kristof; Romao, Ema; et al.
A Repetitive DNA Element Regulates Expression of the Helicobacter pylori Sialic Acid Binding Adhesin by a Rheostat-like Mechanism
PLoS Pathogens, Vol. 10, (7)
Åberg, Anna; Gideonsson, Pär; Vallström, Anna; et al.
Helicobacter pylori Cholesteryl α-Glucosides Contribute to Its Pathogenicity and Immune Response by Natural Killer T Cells
PLOS ONE, Public Library of Science 2013, Vol. 8, (12)
Ito, Yuki; Vela, Jose Luis; Matsumura, Fumiko; et al.
Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence
Open Biology, The Royal Society Publishing 2013, Vol. 3, (10)
Mahdavi, Jafar; Royer, Pierre-Joseph; Sjölinder, Hong S.; et al.
Bioengineered surfaces promote specific protein-glycan mediated binding of the gastric pathogen Helicobacter pylori
Acta biomaterialia, Vol. 9, (11) : 8885-8893
Parreira, P.; Magalhães, A.; Reis, C. A; et al.
Helicobacter pylori cholesteryl alpha-glucosides are critical for bacterial growthand activation of invariant NKT cells
Glycobiology, Vol. 22, (11) : 1635-1636
Ito, Yuki; Vela, Jose Luis; Matsumura, Fumiko; et al.
Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori
Analytical Chemistry, American Chemical Society (ACS) 2011, Vol. 83, (16) : 6336-6341
Fei, Y Y; Schmidt, Alexej; Bylund, Göran; et al.
BabA-mediated adherence is a potentiator of the Helicobacter pylori type IV secretion system activity
Journal of Biological Chemistry, Vol. 286, (28) : 25256-25264
Ishijima, Nozomi; Suzuki, Masato; Ashida, Hiroshi; et al.
Immunological functions of cholesteryl alpha-glucosides in helicobacter pylori-associated inflammation
Glycobiology, Oxford: Oxford University Press, 2011, Vol. 21, (11) : 1485-1486
Ito, Yuki; Vela, Jose Luis; Matsumura, Fumiko; et al.
Life at the margins: modulation of attachment proteins in helicobacter pylori
Gut microbes, Taylor & Francis Group 2011, Vol. 2, (1) : 42-46
Moore, Mary E.; Boren, Thomas; Solnick, Jay V.
Expression of the BabA adhesin during experimental infection with Helicobacter pylori.
Infection and Immunity, Vol. 78, (4) : 1593-600
Styer, Cathy M; Hansen, Lori M; Cooke, Cara L; et al.
Dynamic force spectroscopy of the Helicobacter pylori BabA-Lewis b binding
Biophysical Chemistry, Amsterdam: Elsevier 2009, Vol. 143, (1-2) : 102-105
Björnham, Oscar; Bugaytsova, Jeanna; Borén, Thomas; et al.
Novel Leb-like Helicobacter pylori-binding glycosphingolipid created by the expression of human alpha-1,3/4-fucosyltransferase in FVB/N mouse stomach.
Glycobiology, Vol. 19, (2) : 182-191
Fagerberg, David; Angström, Jonas; Halim, Adnan; et al.
Relapsing fever Borrelia binds to neolacto glycans and mediates rosetting of human erythrocytes.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, (46) : 19280-19285
Guo, Betty P; Teneberg, Susann; Münch, Robert; et al.
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa
Glycobiology, Vol. 19, (12) : 1525-1536
Magalhães, Ana; Gomes, Joana; Ismail, Mohd Nazri; et al.
Outer membrane protein expression profile in Helicobacter pylori clinical isolates
Infection and Immunity, Vol. 77, (9) : 3782-3790
Odenbreit, Stefan; Swoboda, Kirstin; Barwig, Iris; et al.
Identification of glycoprotein receptors within the human salivary proteome for the lectin-like BabA and SabA adhesins of Helicobacter pylori by fluorescence-based 2-D bacterial overlay
Proteomics, Vol. 9, (6) : 1582-1592
Walz, Anke; Odenbreit, Stefan; Stühler, Kai; et al.
Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype
Journal of Pathology, Vol. 215, (3) : 308-316
Azevedo, M; Eriksson, Sara; Mendes, N; et al.
Role of ABO secretor status in mucosal innate immunity and H. pylori infection.
PLoS pathogens, Vol. 4, (1) : e2-
Lindén, Sara; Mahdavi, Jafar; Semino-Mora, Cristina; et al.
Studies of Lewis antigens and H. pylori adhesion in CHO cell lines engineered to express Lewis b determinants
Glycobiology, Vol. 18, (7) : 494-501
Löfling, Jonas; Diswall, Mette; Eriksson, Sara; et al.
Helicobacter pylori is invasive and it may be a facultative intracellular organism.
Cellular microbiology, Vol. 9, (5) : 1108-16
Dubois, Andre; Borén, Thomas
Helicobacter pylori adhesion to carbohydrates.
Methods in enzymology, Vol. 417 : 293-339
Aspholm, Marina; Kalia, Awdhesh; Ruhl, Stefan; et al.
SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.
PLoS Pathog, Vol. 2, (10) : e110-
Aspholm, Marina; Olfat, Farzad O; Nordén, Jenny; et al.
Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine milk.
Glycobiology, Vol. 16, (1) : 1-10
Gustafsson, Anki; Hultberg, Anna; Sjöström, Rolf; et al.
Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea.
The journal of infectious diseases, Vol. 194, (11) : 1580-8
Pant, Neha; Hultberg, Anna; Zhao, Yaofeng; et al.
Immunoproteomics of Actinobacillus actinomycetemcomitans outer-membrane proteins reveal a highly immunoreactive peptidoglycan-associated lipoprotein.
Journal of Medical Microbiology, Vol. 55, (7) : 931-942
Paul-Satyaseela, M; Karched, M; Bian, Z; et al.
Helicobacter pylori SabA adhesin evokes a strong inflammatory response in human neutrophils which is down-regulated by the neutrophil-activating protein.
Medical microbiology and immunology, Vol. 195, (4) : 195-206
Petersson, Christoffer; Forsberg, Maria; Aspholm, Marina; et al.
Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers
Journal of Biomedical Optics, Bellingham, WA: 2005, Vol. 10, (4) : 044024-
Björnham, Oscar; Fällman, Erik; Axner, Ove; et al.
Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries.
FEMS immunology and medical microbiology, Vol. 44, (2) : 151-6
Olfat, Farzad O; Zheng, Quing; Oleastro, Monica; et al.
View publications in DiVA

Research groups

Head of research
Thomas Borén lab