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Verena Kohler

Assistant professor in Molecular Biology

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6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

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Affiliation
Affiliated as other position at Department of Molecular Biology Units: Group Verena Kohler
Affiliation
Assistant professor at Department of Molecular Biology Units: Group Verena Kohler

Cellular proteostasis represents a finely tuned equilibrium between protein production, maintenance, and degradation that is crucial for cellular well-being. At its core, the protein quality control (PQC) system, coordinated by a network of chaperones (the cellular chaperome), actively maintains this balance. It ensures proper protein folding and prevents the accumulation of misfolded proteins, thereby safeguarding cellular health. When proteostasis disruptions exceed the capacity of the PQC system, it leads to toxic protein aggregations with non-native conformations. Prolonged or chronic stress can upset this balance, resulting in proteostasis breakdown, cellular toxicity, and ultimately cell death.
 
Ageing is associated with the accumulation of intracellular damage, which compromises the functional proteome and leads to cellular dysfunction. As organisms age, maintaining proteostasis becomes increasingly challenging, contributing to the development of diseases such as cancer and neurodegenerative disorders. Given the unprecedented ageing of our population, coinciding with a surge in age-related diseases like neurodegenerative disorders, it is essential to uncover the changes in the ageing chaperome, including the structure and vulnerabilities of organellar PQC subsystems. We strongly believe that these insights will provide the foundation for future interventions in translational medicine.
 
We hypothesise that age significantly affects various aspects of organellar PQC. Impaired intracellular communication is a hallmark of ageing, and we expect disruption of communication pathways between suborganellar PQC with advancing age. Our research focuses on molecular details underlying the age-related decline of proteostasis and intracellular communication using high-throughput approaches in yeast, with the ultimate goal of validating and translating these findings into higher eukaryotic model systems.

 

More information: www.vkohler-lab.com

Nature Communications, Springer Nature 2024, Vol. 15, (1)
Kohler, Verena; Kohler, Andreas; Berglund, Lisa Larsson; et al.
Nucleus, Taylor & Francis Group 2023, Vol. 14, (1)
Keuenhof, Katharina S.; Kohler, Verena; Broeskamp, Filomena; et al.
Molecular Cell, Cell Press 2023, Vol. 83, (19) : 3470-3484
Kohler, Andreas; Carlström, Andreas; Nolte, Hendrik; et al.
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2023, Vol. 10
Kohler, Verena; Andréasson, Claes
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2023, Vol. 10
Kohler, Verena; Arunagiri, Anoop; Ventura, Salvador; et al.
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2023, Vol. 16
Kohler, Verena; Braun, Ralf J.; Kohler, Andreas
Acta Physiologica, John Wiley & Sons 2023, Vol. 238, (3)
Vazquez‐Calvo, Carmela; Kohler, Verena; Höög, Johanna L.; et al.
Nature Communications, Nature Publishing Group 2022, Vol. 13, (1)
Diessl, Jutta; Berndtsson, Jens; Broeskamp, Filomena; et al.
Frontiers in Molecular Biosciences, Vol. 9
Kroschwald, Sonja; Arunagiri, Anoop; Ventura, Salvador; et al.
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Peselj, Carlotta; Ebrahimi, Mahsa; Broeskamp, Filomena; et al.
Contact, Sage Publications 2021, Vol. 4
Kohler, Verena; Büttner, Sabrina
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2021, Vol. 118, (30)
Panagaki, Dimitra; Croft, Jacob T.; Keuenhof, Katharina; et al.
Cell Reports, Cell Press 2021, Vol. 34, (3)
Tosal-Castano, Sergi; Peselj, Carlotta; Kohler, Verena; et al.
EMBO Reports, John Wiley & Sons 2020, Vol. 21, (12)
Berndtsson, Jens; Kohler, Andreas; Rathore, Sorbhi; et al.
Genetics, neurology, behavior, and diet in parkinson's disease: The neuroscience of parkinson's, volume 2, Academic Press 2020 : 123-138
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Toxins, MDPI 2020, Vol. 12, (2)
Kohler, Andreas; Kohler, Verena; Khalifa, Shaden; et al.
Biological chemistry (Print), Walter de Gruyter 2020, Vol. 401, (11) : 1233-1248
Kohler, Verena; Andréasson, Claes
Cells, MDPI 2020, Vol. 9, (5) : 1184-1184
Kohler, Verena; Kohler, Andreas; Büttner, Sabrina
Antibiotic drug resistance, John Wiley & Sons 2019 : 141-165
Grohmann, Elisabeth; Kohler, Verena; Vaishampayan, Ankita
Frontiers in Microbiology, Frontiers Media S.A. 2019, Vol. 10
Kohler, Verena; Keller, Walter; Grohmann, Elisabeth
Antibacterial drug discovery to combat MDR: natural compounds, nanotechnology and novel synthetic sources, Springer Nature 2019 : 25-69
Kohler, Verena; Vaishampayan, Ankita; Grohmann, Elisabeth
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2018, Vol. 11
Kohler, Andreas; Kohler, Verena; Walter, Corvin; et al.
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (17) : 9201-9219
Kohler, Verena; Goessweiner-Mohr, Nikolaus; Kohler, Andreas; et al.
Molecular Microbiology, John Wiley & Sons 2018, Vol. 109, (3) : 263-267
Kohler, Verena; Keller, Walter; Grohmann, Elisabeth
Plasmid, Elsevier 2018, Vol. 99 : 11-21
Kohler, Verena; Vaishampayan, Ankita; Grohmann, Elisabeth
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2017, Vol. 10
Kohler, Andreas; Habernig, Lukas; Kohler, Verena; et al.
Neural Regeneration Research, Wolters Kluwer 2017, Vol. 12, (11) : 1776-1776
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Scientific Reports, Nature Publishing Group 2016, Vol. 6, (1)
Fercher, Christian; Probst, Ines; Kohler, Verena; et al.
Cell and Tissue Research, Springer 2016, Vol. 367, (1) : 125-140
Kohler, Andreas; Kohler, Verena; Diessl, Jutta; et al.

Research groups

Head of research
Verena Kohler lab
Published: 15 Feb, 2024