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Umeå University
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Staff photo Verena Kohler

Verena Kohler

Assistant professor in Molecular Biology

0000-0002-1241-162X

Contact

E-mail
verena.kohler@umu.se
Phone
+46 90 786 61 73

Works as

Affiliation
Assistant professor at Department of Molecular Biology Section: Group Verena Kohler
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

We study how cells maintain protein homeostasis (proteostasis), particularly during stress and aging.

Our work combines genome-wide screening in yeast, automated experimental workflows, and data-driven analysis, including bioinformatics and AI-assisted approaches. This allows us to systematically identify regulators of proteostasis and uncover how cellular systems fail over time.

By integrating large-scale experiments with computational methods, we aim to build a systems-level understanding of cellular functionthat is relevant for human health and disease.

 

Mer information: www.vkohler-lab.com

 

Editorial: Cellular contributors and consequences of protein misfolding and aggregation
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2026, Vol. 12
Arunagiri, Anoop; Sontag, Emily; Kohler, Verena; et al.
Crucial gram-positive type iv secretion system protein traf is a structural homolog of type vii secretion system protein essb/yukc
MicroLife, Oxford University Press 2026, Vol. 7
Kuhlmann, Kirill; Stallinger, Amrutha; Michaelis, Claudia; et al.
Better together: interorganellar communication in the regulation of proteostasis
Contact, Sage Publications 2024, Vol. 7 : 1-19
Kohler, Andreas; Kohler, Verena
Nuclear Hsp104 safeguards the dormant translation machinery during quiescence
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Kohler, Verena; Kohler, Andreas; Berglund, Lisa Larsson; et al.
Nuclear envelope budding and its cellular functions
Nucleus, Taylor & Francis Group 2023, Vol. 14, (1)
Keuenhof, Katharina S.; Kohler, Verena; Broeskamp, Filomena; et al.
Early fate decision for mitochondrially encoded proteins by a molecular triage
Molecular Cell, Cell Press 2023, Vol. 83, (19) : 3470-3484
Kohler, Andreas; Carlström, Andreas; Nolte, Hendrik; et al.
Reversible protein assemblies in the proteostasis network in health and disease
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2023, Vol. 10
Kohler, Verena; Andréasson, Claes
Editorial: molecular determinants of protein assemblies in health and disease, volume II
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2023, Vol. 10
Kohler, Verena; Arunagiri, Anoop; Ventura, Salvador; et al.
Editorial: Mitochondria as a hub for neurodegenerative disorders
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2023, Vol. 16
Kohler, Verena; Braun, Ralf J.; Kohler, Andreas
Newly imported proteins in mitochondria are particularly sensitive to aggregation
Acta Physiologica, John Wiley & Sons 2023, Vol. 238, (3)
Vazquez‐Calvo, Carmela; Kohler, Verena; Höög, Johanna L.; et al.
Manganese-driven CoQ deficiency
Nature Communications, Nature Publishing Group 2022, Vol. 13, (1)
Diessl, Jutta; Berndtsson, Jens; Broeskamp, Filomena; et al.
Editorial: Molecular determinants of protein assemblies in health and disease
Frontiers in Molecular Biosciences, Vol. 9
Kroschwald, Sonja; Arunagiri, Anoop; Ventura, Salvador; et al.
Sterol metabolism differentially contributes to maintenance and exit of quiescence
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Peselj, Carlotta; Ebrahimi, Mahsa; Broeskamp, Filomena; et al.
Remodelling of nucleus-vacuole junctions during metabolic and proteostatic stress
Contact, Sage Publications 2021, Vol. 4
Kohler, Verena; Büttner, Sabrina
Nuclear envelope budding is a response to cellular stress
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2021, Vol. 118, (30)
Panagaki, Dimitra; Croft, Jacob T.; Keuenhof, Katharina; et al.
Snd3 controls nucleus-vacuole junctions in response to glucose signaling
Cell Reports, Cell Press 2021, Vol. 34, (3)
Tosal-Castano, Sergi; Peselj, Carlotta; Kohler, Verena; et al.
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance
EMBO Reports, John Wiley & Sons 2020, Vol. 21, (12)
Berndtsson, Jens; Kohler, Andreas; Rathore, Sorbhi; et al.
The mitochondrial network in Parkinson's disease
Genetics, neurology, behavior, and diet in parkinson's disease: The neuroscience of parkinson's, volume 2, Academic Press 2020 : 123-138
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis: limitations and possibilities
Toxins, MDPI 2020, Vol. 12, (2)
Kohler, Andreas; Kohler, Verena; Khalifa, Shaden; et al.
Hsp70-mediated quality control: should I stay or should I go?
Biological chemistry (Print), Walter de Gruyter 2020, Vol. 401, (11) : 1233-1248
Kohler, Verena; Andréasson, Claes
Closing the gap: membrane contact sites in the regulation of autophagy
Cells, MDPI 2020, Vol. 9, (5) : 1184-1184
Kohler, Verena; Kohler, Andreas; Büttner, Sabrina
Acquired resistance from gene transfer
Antibiotic drug resistance, John Wiley & Sons 2019 : 141-165
Grohmann, Elisabeth; Kohler, Verena; Vaishampayan, Ankita
Regulation of gram-positive conjugation
Frontiers in Microbiology, Frontiers Media S.A. 2019, Vol. 10
Kohler, Verena; Keller, Walter; Grohmann, Elisabeth
Problematic groups of multidrug-resistant bacteria and their resistance mechanisms
Antibacterial drug discovery to combat MDR: natural compounds, nanotechnology and novel synthetic sources, Springer Nature 2019 : 25-69
Kohler, Verena; Vaishampayan, Ankita; Grohmann, Elisabeth
The enzymatic core of the Parkinson’s disease-associated protein LRRK2 impairs mitochondrial biogenesis in aging yeast
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2018, Vol. 11
Kohler, Andreas; Kohler, Verena; Walter, Corvin; et al.
TraN: A novel repressor of an Enterococcus conjugative type IV secretion system
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (17) : 9201-9219
Kohler, Verena; Goessweiner-Mohr, Nikolaus; Kohler, Andreas; et al.
Enterococcus adhesin PrgB facilitates type IV secretion by condensation of extracellular DNA
Molecular Microbiology, John Wiley & Sons 2018, Vol. 109, (3) : 263-267
Kohler, Verena; Keller, Walter; Grohmann, Elisabeth
Broad-host-range Inc18 plasmids: Occurrence, spread and transfer mechanisms
Plasmid, Elsevier 2018, Vol. 99 : 11-21
Kohler, Verena; Vaishampayan, Ankita; Grohmann, Elisabeth
The coordinated action of calcineurin and cathepsin d protects against α-synuclein toxicity
Frontiers in Molecular Neuroscience, Frontiers Media S.A. 2017, Vol. 10
Kohler, Andreas; Habernig, Lukas; Kohler, Verena; et al.
Taking out the garbage: cathepsin D and calcineurin in neurodegeneration
Neural Regeneration Research, Wolters Kluwer 2017, Vol. 12, (11) : 1776-1776
Kohler, Andreas; Kohler, Verena; Büttner, Sabrina
Conjugative type IV secretion in Gram-positive pathogens: TraG, a lytic transglycosylase and endopeptidase, interacts with translocation channel protein TraM
Plasmid, Elsevier 2017, Vol. 91 : 9-18
Kohler, Verena; Probst, Ines; Kohler, Andreas; et al.
VirB8-like protein TraH is crucial for DNA transfer in Enterococcus faecalis
Scientific Reports, Nature Publishing Group 2016, Vol. 6, (1)
Fercher, Christian; Probst, Ines; Kohler, Verena; et al.
Mitochondrial lipids in neurodegeneration
Cell and Tissue Research, Springer 2016, Vol. 367, (1) : 125-140
Kohler, Andreas; Kohler, Verena; Diessl, Jutta; et al.
View publications in DiVA

Research groups

Head of research
Verena Kohler lab

I am the course leader for “Cell biology” (5MO100/3MB038) targeted at Bachelor’s students of Life Science and Biomedicine