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Utvalda publikationer

Jones, I., Hägglund, A-C. and Carlsson, L. Reduced mTORC1-signaling in retinal ganglion cells leads to vascular retinopathy. (2022). Dev. Dyn. 251:321-335. https://doi.org/10.1002/dvdy.389

Cova, G., Taroni, C., Deau, M-C., Cai, Q., Mittelheisser, V., Philipps, M., Jung, M., Cerciat, M., Le Gras, S., Thibault-Carpentier, C., Jost, B., Carlsson, L., Thornton, A., Shevach, E., Kirstetter, P. and Kastner, P. and Chan, S. Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. (2021) J. Exp. Med. 218(10):1-18

Jones, I., Novikova, L., Wiberg, M., Carlsson, L. and Novikov, L. Human embryonic stem cell-derived neural crest cells promote sprouting and motor recovery following spinal cord injury in adult rats. (2021) Cell Transplant. 30:1-17. https://doi.org/10.1177/0963689720988245

Doma, E., Mayer, IM., Brandstoetter, T., Maurer, B., Grausenburger, R., Menzl, I., Zojer, M., Hoelbl-Kovacic, A., Carlsson, L., Heller, G., Kollmann, K. and Sexl, V. A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation. (2021) Blood Advances 5:39-53. https://doi.org/10.1182/bloodadvances.2020003022

Comai, GE., Tesarova, M., Dupé, V., Rhinn, M., Vallecillo-Garcia, P., da Silva, F., Feret, B., Exelby, K., Dollé, P., Carlsson, L., Pryce, B., Spitz, F., Stricker, S., Zikmund, T., Kaiser, J., Briscoe, J., Schedl, A., Norbert B., Ghyselinck, N., Schweitzer, R. and Tajbakhsh, S. Local retinoic acid signalling directs emergence of the extraocular muscle functional unit. (2020) PLoSBiol 18:e3000902. https://doi.org/10.1371/journal.pbio.3000902

Jones, I., Hägglund, A-C. and Carlsson, L. Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction. (2019) Biol. Open 8:bio044370

Jones, I., Yelhekar, T. D., Wiberg, R., Kingham, P., Johansson, S., Wiberg, M. and Carlsson, L. Development and validation of an in vitro model system to study peripheral sensory neuron development and injury.Scientific Rep. (2018) 8:15961-15975

Jones, I., Novikova, L., Novikov, L., Renardy, M., Ullrich, A., Wiberg, M., Carlsson, L. and Kingham, P. Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury. J. Tissue Eng. Regen. Med. (2018) 12:e2099-e2109.

Hägglund, A-C., Jones, I. and Carlsson, L. A novel mouse model of anterior segment dysgenesis (ASD): Conditional deletion of Tsc1 disrupts ciliary body and iris development. Dis. Mod. Mech. (2017) 10:245-257.

Jones, I., Hägglund, A-C., Törnqvist, G., Nord, C., Ahlgren, U. and Carlsson, L. A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis. Mod. Mech. (2015) 8:1517-29

Hägglund, A.-C., Berghard, A. and Carlsson, L. Canonical Wnt/β-catenin signalling is essential for optic cup formation. PLoS ONE (2013) 8:e81158

Berghard, A., Hägglund, A.-C., Bohm, S. and Carlsson, L. Lhx2-dependent specification of olfactory sensory neurons is required for successful integration of olfactory, vomeronasal, and GnRH neurons.
FASEB J. (2012) 8:3464-72

Hägglund, A-C., Dahl, L. and Carlsson, L. Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. PLoS ONE (2011) 6:e23387

Törnqvist, G., Sandberg, A., Hägglund, A-C. and Carlsson, L. Cyclic expression of Lhx2 regulates hair formation. PLoS Gen. (2010) 6:e1000904

Dahl, L., Richter, K., Hägglund, A-C. and Carlsson, L. Lhx2 expression promotes self-renewal of a distinct multipotential hematopoietic progenitor cell in embryonic stem cell-derived embryoid bodies. PLoS ONE (2008) 3(4):e2025

Liu, H., Carlsson, L. and Grundström, T. Identification of an N-terminal transactivation domain of Runx1 that separates molecular function from global differentiation function. J. Biol. Chem. (2006) 281:25659-25669

Richter, K., Wirta, V., Dahl, L., Bruce, S., Lundeberg, J., Carlsson, L. and Williams, C. Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression. BMC Genomics (2006) 7:75.

Utsugisawa, T., Moody, J., Aspling, M., Nilsson, E., Carlsson, L. and Karlsson, S. A Road Map Toward Defining the Role of Smad Signaling in Hematopoietic Stem Cells. Stem Cells (2006) 24:1128-1136

Wandzioch, E., Kolterud, Å., Jacobsson, M., Friedman, S. and Carlsson, L. Lhx2-/- mice develop liver fibrosis. Proc. Natl. Acad. Sci. U S A (2004) 101:16549-16554.

Kolterud, Å., Alenius, M., Carlsson, L. and Bohm, S. The LIM homeobox gene Lhx2 is required for olfactory sensory neuron identity. Development (2004) 131:5319-5326.

Kolterud, Å., Wandzioch, E. and Carlsson, L. Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of functional Lhx2. Gene Expr. Patterns (2004) 4:521-528.

Wandzioch, E., Edling, C., Palmer, R., Carlsson, L. and Hallberg, B. Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines. Blood (2004) 104:51-57.

Richter, K., Pinto do Ó, P., Hägglund, A.-C., Wahlin, A. and Carlsson, L. Lhx2 expression in hematopoietic progenitor/stem cells in vivo causes a chronic myeloproliferative disorder and altered globin expression. Haematologica (2003) 88:1336-1347.

Pinto do Ó, P. Richter, K. and Carlsson, L. Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo. Blood (2002) 99:3939-3946.

Pinto do Ó, P., Wandzioch, E., Kolterud, Å. and Carlsson, L. Multipotent hematopoietic progenitor cells immortalized by Lhx2 self-renew by a cell nonautonomous mechanism. Exp. Hematol. (2001) 29:1019-1028.

Pinto do Ó, P., Kolterud, Å. and Carlsson, L. Expression of the LIM-homeobox gene LH2 generates immortalized Steel factor-dependent multipotent hematopoietic precursors. EMBO J. (1998) 17:5744-5756.

Lacaud, G., Carlsson, L. and Keller, G. Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential. Immunity (1998) 9:827-838.

Carlsson, L. Candeais, S., Staerz, U. and Keller, G. Expression of Fc gamma RIII defined distinct subpopulations of fetal liver B cell and myeloid precursors. Eur J. Immunol. (1995) 25:2308-2317


Carlsson, L. Periodiskt uttryck av genen Lhx2 reglerar hårväxten. Läkartidningen (2010) 107:1616

Carlsson, L. and Danielsson, Å. Lhx2 tycks hindra uppkomst av levercirros. Genfynd ger möjlighet att utveckla läkemedel mot enormt hälsoproblem. Läkartidningen (2006) 103:1594-1597. (The Journal of the Swedish Medical Association, swedish with english summary. Lhx2 seems to inhibit the development of liver cirrhosis. Gene discovery makes the development of drugs against this enormous health problem possible)

Carlsson, L., Wandzioch, E., Pinto do Ó, P. and Kolterud, Å. Establishment of multipotent hematopoietic progenitor cell lines from ES cells differentiated in vitro. Meth. Enzymol. (2003) 365:202-214.o:p

Senast uppdaterad: 2022-10-28