Talare: Harald Stenmark, Oslo universitet.
Expertis: Intracellulär membrandynamik, fosfoinositider (PIPs), ESCRT-proteiner
Värd: Yaowen Wu, Kemiska institutionen
Föredraget är på engelska
Lysosomes are the main degradative organelles of the cell, and they also serve as hubs for metabolic signalling. Since lysosomes contain proteases and cations that are toxic to the cell if they accumulate in the cytosol, it is essential for cellular health to maintain the integrity of the lysosome membrane. Impairment of lysosomal membrane integrity is associated with hyperinflammation and neurodegenerative diseases. In our laboratory we have discovered two mechanisms that serve to repair damaged lysosomes. The first involves the endosomal sorting complex required for transport (ESCRT) machinery, whereas the other involves lipid transfer from the endoplasmic reticulum (ER). In this presentation I will present novel insight into how the ER responds to lysosome damage in order to repair the damaged lysosome membrane.
Harald Stenmark is professor at University of Oslo, where he is director of a Norwegian Centre of Excellence, Centre for Cancer Cell Reprogramming. He is also Head of Department of Molecular Cell Biology at Institute for Cancer Research, Oslo University Hospital.
Stenmark obtained his PhD degree in cell biology at University of Oslo in 1991 and was a postdoc at European Molecular Biology Laboratory in Heidelberg, Germany from 1991 to 1994. Since 1995 he has held various research positions at University of Oslo and Oslo University Hospital.
Stenmark is elected member of European Molecular Biology Organization (EMBO), European Academy of Cancer Sciences (EACS), the Norwegian Academy of Science and Letters, the Royal Norwegian Academy of Sciences and Letters, and the Academy of Europe.
Stenmark has published some 300 papers in the fields of cellular membrane dynamics and basic cancer research, with special emphasis on the functions of Rab GTPases, phosphoinositides and ESCRT proteins in regulation of endocytosis, autophagy, cell signalling, cell migration, cell division, and membrane repair.